Biological effect of Parsley and honey on side effects of Cisplatin induced nephrotoxicity in experimental male rats

Abstract

ABSTRACThe research was carried out on 50 adult albino male rats (Sprague -Dawley strain) weighing 160±7 g. 10 rats served as control negative group and 40 rats were injected with Cisplatin (7.5 mg/kg bwt, ip)

Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats

“…Despite its beneficial application as an anti-neoplastic agent, CIS causes several toxicities that limit its clinical use including nephrotoxicity, hepatotoxicity, cardiotoxicity, neurotoxicity, and ototoxicity ( Hassan et al, 2020 , Yadav, 2019 , Neamatallah et al, 2018 ). Many experimental studies documented the common toxic side effects associated with CIS, especially nephrotoxicity ( Tahoon, 2017 ). Besides, hepatotoxicity has been identified as a significant dose-limiting side effect of CIS-based chemotherapy ( Apaydin et al, 2018 , Omar et al, 2016a , İşeri et al, 2007 ;) whereas CIS accumulates in the liver at a significant amount secondly to kidney ( Liao et al, 2008 ).…”

Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats

“…CP induces many toxicities, including nephrotoxicity, hepatotoxicity, cardiotoxicity, neurotoxicity and ototoxicity, which restrict its clinical usage [ 2 , 3 , 4 ]. A large number of experimental research papers have provided evidence of the prevalent toxic side effects associated with CP, most notably nephrotoxicity [ 5 ]. Additionally, it has been shown that hepatotoxicity is a prominent dose-limiting adverse effect of CP-based chemotherapy [ 6 , 7 ].…”