Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents

Mocan, Andrei; Zengin, Gökhan; Mollica, Adriano; Uysal, Ahmet; Güneş, Erdoğan; Crișan, Gianina

doi:10.1016/j.fct.2017.08.004

Cited by 34 publications

(27 citation statements)

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“…The procedures of these assays were reported in our earlier work. [23][24][25][26][27] The enzyme inhibitor effects were evaluated as equivalents of acarbose for a-amylase, galantamine for acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE), and kojic acid (KAE) for tyrosinase.…”

Section: Enzyme Inhibitory Activitymentioning

confidence: 99%

“…The activity for EA may be linked with the higher level of phenolics and this approach was supported by several researchers, who reported the positive correlation between phenolic level and AChE inhibition. 27,36 However, the BChE inhibition effects can be ranked as H 2 O > EtOH > EA > MeOH. The observed BChE inhibitor effect for H 2 O can be attributed to non-phenolic inhibitors 37 since the water extract, as expected, exhibited the lowest phenolic level (see Table 2).…”

Section: Enzyme Inhibitory Effects Of the A Vulgaris Extractsmentioning

confidence: 99%

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Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

et al. 2019

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Section: Enzyme Inhibitory Activitymentioning

confidence: 99%

Section: Enzyme Inhibitory Effects Of the A Vulgaris Extractsmentioning

confidence: 99%

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

et al. 2019

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“…This results showed that inhibition of mutagenic substrates, which needs metabolic activation, such as 2-AA and 2-AF in our study can be attributed to inhibition of cytochrome P450 isoenzymes. Also Charehsaz et al [41] and Mocan et al [42] indicated that protective effects of plant extracts increased in the presence of S9 metabolic activation system by inhibiting cytochrome P450 monooxygenases.…”

Section: Discussionmentioning

confidence: 98%

Elucidation of biological properties of some commercial anthraquinones: Mutagenic / antimutagenic and antimicrobial activity approaches

Uysal¹,

Güneş²,

Durak³

2019

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Anthraquinones (AQ) are the most common group of naturally occurring quinones. Both natural and synthetic AQs have been used as colorants in food, drugs and cosmetic industries. The aim of this study was to evaluate the mutagenic/antimutagenic potentials of some AQs (Alizarin, quinizarin, purpurin, and 1,8-dihydroxy anthraquinone) with Salmonella typhimurium TA98 and TA100 strains by Ames test and antimicrobial activity by broth microdilution method. So, AQs were tested for their toxicity and nontoxic doses of the chemicals were used. The results manifested that none of the chemicals were mutagenic for TA98 and TA100 strains both with and without metabolic activation enzymes (S9 mix). Purpurin and alizarin exhibited strong antimutagenic effects against 4nitrophenylendiameine and 2-aminoflourene at all test doses (1000, 500 and 250 µg/plate) for TA98; and against sodium azide and 2-aminoanthracene for TA100. Alizarin showed the highest inhibition rate (93%) against sodium azide at a concentration of 1000 µg/plate. While 1,8-dihydroxy anthraquinone and quinizarin revealed strong antimutagenicity at 10000 µg/plate without S9 mix, they exhibited excellent antimutagenic action after addition of S9 enzymes for TA98 strain at all test doses. Similarly, 1,8-dihydroxy anthraquinone and quinizarin were moderate antimutagenic against sodium azide at all test doses without S9 mix, their antimutagenicity increased and they ameliorated the mutagenic action of 2-aminoanthracene by the addition of S9 for TA100. These two chemicals were strong antimutagenic against promutagens activated by S9 mix. Also it was defined that purpurin and alizarin have antimicrobial capacity against MRSA strains.

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“…Peaks 1-6 with deprotonated molecules at m/z: 133.01357, 191.01907, 147.02913, 205.03491, and 137.02357 were identified as malic, citric, and hydroxyglutaric acid (Schor et al, 2002) and its isomer, homo(iso)citric and hydroxybenzoic acids, (Mocan et al, 2018) respectively. Peak 7 was assigned tentatively as a dehydro-shikimic acid (C 7 H 11 O 5 − ) while peak 8 with a parent ion at m/z: 175.0243 MS 2 ions at m/z: 115.0071; 113.01269; and 87.00942, was identified as ascorbic acid (C 6 H 7 O 6 − ) (Boonpangrak et al, 2016).…”

Section: Organic Acids and Other Phenolic Derivativesmentioning

confidence: 99%

Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry

et al. 2020

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Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae) is a shrubby or often arborescent cactus popularly known as "sancayo" and produce an edible fruit known as "Sanky" which is consumed in Arequipa-Perú. The purpose of this study was to report the gastroprotective activity and relate this activity to the antioxidant capacity and presence of phenolic compounds for the first time. A metabolomic profiling based on Ultrahigh-pressure liquid chromatography and electrospray high resolution mass spectrometry, and the antioxidant activities (DPPH, ABTS, and FRAP), ascorbic acid content, total phenolics and flavonoids contents, and the mode of gastroprotective action of the Sanky fruit including the involvement of prostaglandins, nitric oxide, and sulfhydryl compounds is reported. Thirty-eight compounds were detected in the ethanolic extract including 12 organic acids, nine hydroxycinnamic acids, three isoamericanol derivatives, six flavonoids, five fatty acids, and two sterols. The results of the biological tests showed that the ethanolic extract had antioxidant capacity and gastroprotective activity on the model of HCl/EtOH-induced gastric lesions in mice (at 10, 25, 50, and 100 mg/kg). The effect elicited by the extract at 50 mg/kg was reversed by indometacin and Nethylmaleimide but not by N G-nitro-L-arginine methyl ester suggesting that sulfhydryl groups and prostaglandins are involved in the mode of gastroprotective action. In

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Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents

Cited by 34 publications

References 50 publications

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Elucidation of biological properties of some commercial anthraquinones: Mutagenic / antimutagenic and antimicrobial activity approaches

Corryocactus brevistylus (K. Schum. ex Vaupel) Britton & Rose (Cactaceae): Antioxidant, Gastroprotective Effects, and Metabolomic Profiling by Ultrahigh-Pressure Liquid Chromatography and Electrospray High Resolution Orbitrap Tandem Mass Spectrometry

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