Biological effects of conjugated linoleic acid on obesity-related cancers

Moon, Hee Sun

doi:10.1016/j.cbi.2014.11.006

Cited by 21 publications

(15 citation statements)

References 73 publications

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“…Increasing the availability of VA to the mammary gland increases the proportion of RA in milk. Ruminant products are the largest contributor to RA intake in the human diet (Ritzenthaler et al, 2001 ), and previous research suggests that RA imparts health benefits (Pariza, 2004 ; Moon, 2014 ). Several bacterial species are known to produce RA and VA, including Butyrivibrio (Kim, 2003 ; Wallace et al, 2007 ), which were identified in this study, and several bacteria, not reported in this study, such as Bifidobacteria, Lactobacilli , and Propionibacteria (Ogawa et al, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

“…Blood plasma proportions of OCFA in humans have been linked to a decreased risk of coronary heart disease (CHD) (Khaw et al, 2012 ) and type 2 diabetes (Forouhi et al, 2014 ). Rumen bacteria biohydrogenate feed-derived unsaturated FA producing a wide variety of intermediates, such as conjugated linoleic acids (CLA) and vaccenic acid (VA; 18:1 t 11), that have been shown to reduce tumor growth (Moon, 2014 ) and risk for CHD (Field et al, 2009 ). n-3 FA are widely known for their anti-inflammatory, anti-carcinogenic, and cardio-protective effects (Zhao et al, 2004 ; Liu and Ma, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Alteration of Rumen Bacteria and Protozoa Through Grazing Regime as a Tool to Enhance the Bioactive Fatty Acid Content of Bovine Milk

et al. 2018

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Rumen microorganisms are the origin of many bioactive fatty acids (FA) found in ruminant-derived food products. Differences in plant leaf anatomy and chemical composition between cool- and warm-season pastures may alter rumen microorganisms, potentially enhancing the quantity/profile of bioactive FA available for incorporation into milk. The objective of this study was to identify rumen bacteria and protozoa and their cellular FA when cows grazed a warm-season annual, pearl millet (PM), in comparison to a diverse cool-season pasture (CSP). Individual rumen digesta samples were obtained from five Holstein cows in a repeated measures design with 28-day periods. The treatment sequence was PM, CSP, then PM. Microbial DNA was extracted from rumen digesta and sequence reads were produced with Illumina MiSeq. Fatty acids (FA) were identified in rumen bacteria and protozoa using gas-liquid chromatography/mass spectroscopy. Microbial communities shifted in response to grazing regime. Bacteria of the phylum Bacteroidetes were more abundant during PM than CSP (P < 0.05), while protozoa of the genus Eudiplodinium were more abundant during CSP than PM (P < 0.05). Microbial cellular FA profiles differed between treatments. Bacteria and protozoa from cows grazing CSP contained more n-3 FA (P < 0.001) and vaccenic acid (P < 0.01), but lower proportions of branched-chain FA (P < 0.05). Microbial FA correlated with microbial taxa and levels of vaccenic acid, rumenic acid, and α-linolenic acid in milk. In conclusion, grazing regime can potentially be used to alter microbial communities shifting the FA profile of microbial cells, and subsequently, alter the milk FA profile.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alteration of Rumen Bacteria and Protozoa Through Grazing Regime as a Tool to Enhance the Bioactive Fatty Acid Content of Bovine Milk

et al. 2018

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“…This initial discovery lead to a series of studies that identified a broad range of beneficial biological properties of CLA, including but not limited to effects on weight loss, food and energy intake, alteration of body composition, cancer, enhancement of immune function, and inflammation (Lee et al, 1994;O'Shea et al, 2004;Kelley et al, 2007;Whigham et al, 2007;Mitchell and McLeod 2008). The antiobesity, anticarcinogenic, anti-inflammatory and antidiabetic effects of CLA have been widely described in animal studies (Park et al, 1997;West et al, 1998;de Lany et al, 1999;Ostrowska et al, 1999;Park et al, 1999;Tsuboyama-Kasaoka et al, 2000;Whigham et al, 2000;Bassaganya-Riera et al, 2001a;Ryder et al, 2001;Sisk et al, 2001;Bassaganya-Riera et al, 2002;Hontecillas et al, 2002;Terpstra et al, 2002;Yamasaki et al, 2003b;Bassaganya-Riera et al, 2004;O'Shea et al, 2004;Bassaganya-Riera and Hontecillas, 2006;Evans et al, 2010;Moon, 2014). However, such effects seem to be inconsistent and less significant in humans.…”

Section: Introductionmentioning

confidence: 99%

Modulation of inflammation and immunity by dietary conjugated linoleic acid

Viladomiu¹,

Hontecillas²,

Bassaganya‐Riera

2016

European Journal of Pharmacology

142

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“…Bioactive FA in dairy products, such as α-linolenic acid (ALA; 18:3 c 9, c 12, c 15), conjugated linoleic acids (CLA), and vaccenic acid (VA; 18:1 t 11), are typically present in low percentages in milk (<5%), but exert a significant biological impact on human health [ 1 ]. CLA have been shown to have anti-carcinogenic effects [ 2 ], and research suggests VA can reduce tumor growth and the risk of cardiovascular diseases (CVD) [ 3 ], while ALA has demonstrated protective effects against inflammation [ 4 ], neurological disorders [ 5 ], and CVD [ 6 ]. This is supported by several observational studies and diet-intervention trials that associated milk consumption with a lower risk for CVD and type 2 diabetes [ 6 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Content and Composition of Branched-Chain Fatty Acids in Bovine Milk Are Affected by Lactation Stage and Breed of Dairy Cow

et al. 2016

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Dairy products contain bioactive fatty acids (FA) and are a unique dietary source of an emerging class of bioactive FA, branched-chain fatty acids (BCFA). The objective of this study was to compare the content and profile of bioactive FA in milk, with emphasis on BCFA, among Holstein (HO), Jersey (JE), and first generation HO x JE crossbreeds (CB) across a lactation to better understand the impact of these factors on FA of interest to human health. Twenty-two primiparous cows (n = 7 HO, n = 7 CB, n = 8 JE) were followed across a lactation. All cows were fed a consistent total mixed ration (TMR) at a 70:30 forage to concentrate ratio. Time points were defined as 5 days in milk (DIM), 95 DIM, 185 DIM, and 275 DIM. HO and CB had a higher content of n-3 FA at 5 DIM than JE and a lower n-6:n-3 ratio. Time point had an effect on the n-6:n-3 ratio, with the lowest value observed at 5 DIM and the highest at 185 DIM. The content of vaccenic acid was highest at 5 DIM, yet rumenic acid was unaffected by time point or breed. Total odd and BCFA (OBCFA) were higher in JE than HO and CB at 185 and 275 DIM. Breed affected the content of individual BCFA. The content of iso-14:0 and iso-16:0 in milk was higher in JE than HO and CB from 95 to 275 DIM. Total OBCFA were affected by time point, with the highest content in milk at 275 DIM. In conclusion, HO and CB exhibited a higher content of several bioactive FA in milk than JE. Across a lactation the greatest content of bioactive FA in milk occurred at 5 DIM and OBCFA were highest at 275 DIM.

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Biological effects of conjugated linoleic acid on obesity-related cancers

Cited by 21 publications

References 73 publications

Alteration of Rumen Bacteria and Protozoa Through Grazing Regime as a Tool to Enhance the Bioactive Fatty Acid Content of Bovine Milk

Alteration of Rumen Bacteria and Protozoa Through Grazing Regime as a Tool to Enhance the Bioactive Fatty Acid Content of Bovine Milk

Modulation of inflammation and immunity by dietary conjugated linoleic acid

Content and Composition of Branched-Chain Fatty Acids in Bovine Milk Are Affected by Lactation Stage and Breed of Dairy Cow

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