Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Siddiqui, Shafayet Ahmed; Rashid, Md. Mamun Or; Uddin, Md. Giash; Robel, Fataha Nur; Hossain, Mohammad Salim; Haque, Md Azizul; Jakaria, Md.

doi:10.1042/bsr20193972

Cited by 66 publications

(31 citation statements)

References 35 publications

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“…Animals were maintained as the published article by Siddiqui et al (2020) [ 15 ]. Six to 7 week-old Swiss albino mice weighing 22–30 g were purchased from the animal research division of the Jahangirnagar University, Dhaka, Bangladesh.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia leaves (AFMV) through in vitro and in vivo experimental models. The thrombolytic and anti-arthritic effects of AFMV were evaluated by using the clot lysis technique and inhibition of protein denaturation technique, respectively. The anti-nociceptive activity of AFMV was investigated in Swiss Albino mice by acetic acid-induced writhing test and formalin-induced paw licking test. The antioxidant activities of AFMV, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and total reducing power, were also tested. The qualitative phytochemical assays exhibited AFMV contains secondary metabolites such as alkaloid, carbohydrate, flavonoid, tannin, triterpenoids and phenols. In addition, AFMV showed strong antioxidant effects with the highest scavenging activity (IC50 146.61 µg/mL) and reducing power was increased with a dose-dependent manner. AFMV also revealed notable clot lysis effect and substantial anti-arthritic activity at higher doses (500 µg/mL) as compared with the control. The results demonstrated a promising reduction of the number of writhing and duration of paw licking in acetic acid-induced writhing test and formalin-induced paw licking test in a dose-dependent manner, respectively. In conclusion, AFMV provides the scientific basis of its folkloric usage, suggesting it as the vital source of dietary supplement.

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Section: Methodsmentioning

confidence: 99%

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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“…Zinc improves hepatic glycogenesis during its activities in the insulin pathway, thereby modifying glucose utilization. Zinc preserves the structure of insulin and plays a role in storage, biosynthesis and, insulin secretion [ 90 – 92 ].…”

Section: Macromolecules Used In the Synthesis Of Zinc Nssmentioning

confidence: 99%

Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications

et al. 2022

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Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures’ crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.

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“…ZnO NPs have antibacterial and antifungal properties that are used in prophylactic drugs against bacterial disease [10]. ZnO NPs, as a new agent for zinc delivery, in addition to its biotechnological applications, have many implications for the treatment of numerous diseases, including diabetes [11].…”

Section: Introductionmentioning

confidence: 99%

The Combinatory Effects of Zinc Oxide Nanoparticles (ZnO NPs) and Thiamine on Skin of Alloxan-Induced Diabetic Mice; A Stereological and Biochemical Study

Dehkordi

Sekineh

Dehkordi

et al. 2022

Preprint

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Various studies have shown that ZnO NPs as an anti-diabetic agent can be effective in the experimental model of diabetes. This study aimed to investigate treatment effects of ZnO NPs plus thiamine on histo-stereological and biochemical parameters in the diabetic mouse skin. In total 49 BALB/C mice were used and divided into seven groups. Fourteen mice were equally considered as the control and thiamine groups (groups I and II). The rest of the mice were injected with alloxan (220 mg/kg) to induce diabetes; one untreated diabetes group (group III). Other diabetic mice were treated with ZnO NPs (0.1 and 0.5 mg/kg) alone (groups IV and V, respectively) and along with thiamine (groups VI and VII, respectively). Body weights of mice at days 0, 10, and 20 were calculated to appraise weight gain. Stereological and biochemical parameters were measured to evaluate diabetes effects in all groups. An increase in weight was observed in the diabetic group compared to the control group. Diabetic skin showed decreasing in volume density of collagen bundles and decreasing in the epidermis and dermis thickness, as well as an increase in the hypodermis's thickness. Administration of ZnO NPs (0.1 and 0.5 mg/kg) alone and along with thiamine in the diabetic animals resulted in anti-hyperglycemic activity, reducing GGT, BUN, Cr, MDA, and NO levels in treated diabetic mice. In conclusion, the concomitant use of ZnO NPs along with thiamine presents the potential as a combination therapy for the treatment of alloxan-induced diabetic mice skin changes.

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Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Cited by 66 publications

References 35 publications

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications

The Combinatory Effects of Zinc Oxide Nanoparticles (ZnO NPs) and Thiamine on Skin of Alloxan-Induced Diabetic Mice; A Stereological and Biochemical Study

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