Biological efficiency of citrates of microelements in animal breeding

Iskra, R.; Vlislo, V.; Fedoruk, R. S.

doi:10.15407/agrisp4.03.028

Cited by 7 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taking into account the broad spectrum of biological activity of mineral and organic compounds of I, Se, and S, research on the influence of these citrates and other trace elements on the organism of animals was begun in Ukraine (Dolaychuk et al, 2015;Iskra et al, 2017;Stoika et al, 2017). The results of earlier studies indicate the pronounced biological effect of these compounds in low concentrations without manifestations of toxic reaction in the body of rats (Dolaychuk et al, 2015;Fedoruk at al., 2018) and cows, pigs, rabbits, bees (Iskra et al, 2017;Malavolta & Mocchegiani, 2018). Studies by other authors (Mohapatra et al, 2014;Yausheva et al, 2016;Landry et al, 2017) stipulate a stimulating metabolic effect of nanosized compounds of biotic mineral elements.…”

Section: Introductionmentioning

confidence: 99%

“…Studies by other authors (Mohapatra et al, 2014;Yausheva et al, 2016;Landry et al, 2017) stipulate a stimulating metabolic effect of nanosized compounds of biotic mineral elements. Adequate physiological ratios of I, Se, Cr, Ge citrates, for their combined use in laboratory animals were experimentally determined (Dolaychuk et al, 2015;Iskra et al, 2017). Feeding mature, 4-8-month-old, rats (feeding started at 4 months and lasted till the end of the 8 th month) and young, 0-4-monthold, rats (feeding started at birth and lasted for 4 months) with "nanoaquacitrates" of germanium, chromium, and selenium causes an increase of physiological reactivity in their bodies (Dolaychuk et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Feeding mature, 4-8-month-old, rats (feeding started at 4 months and lasted till the end of the 8 th month) and young, 0-4-monthold, rats (feeding started at birth and lasted for 4 months) with "nanoaquacitrates" of germanium, chromium, and selenium causes an increase of physiological reactivity in their bodies (Dolaychuk et al, 2015). The study of the biological activity of new derivatives of organic compounds I, Se, S, including those obtained on the basis of nanotechnology, indicates their high physiological activity (Yausheva et al, 2016;Iskra et al, 2017;Stoika et al, 2017). Environmental considerations and regulations limiting trace mineral supply and improvements in analytical methods to detect putative contaminants in mineral sources have led to a need for a re-examination of trace mineral requirements.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biological effects of iodine, selenium, sulfur citrates in broiler chickens

Fedoruk

Tesarivska

Kovalchuk

et al. 2021

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

This study aimed at the assessment of the I, Se, S citrate effect on the organism of broiler chickens. Feeding of chickens of all groups was carried out by using standard balanced feeds – starter, grower, and finish with the use of group feeders placed at the appropriate height from the floor depending on the poultry height. For the chickens of experimental groups, I, Se, S citrate was added to drinking water daily during the 48th day. To the drinking water of chickens of experimental groups different amounts of the citrate solution were added I (200 mg/L), Se (50 mg/L), S (300 mg/L), prepared by the nanotechnology method. Chickens of the II group received the lowest dose of I, Se, S at the rate of 5 μg I/L, 1.25 μg Se/L, 7.5 μg S/L of drinking water, and for poultry of other experimental groups, it was increased by 2 (III), 4 (IV), 6 (V) and 8 (VI) times compared to II group. Coccidiostat "Kokcisan 12%" (KRKA, Slovenia) was added to the starter and grower feed at the stages of its manufacture in quantities of 0.5 kg/t of feed. Coccidiostat was not added to the final feed. During the 48-day technological period, the clinical condition of the poultry was monitored daily by forage and motor activity, safety, and every 7 days – for growth intensity with the individual determination of body weight on a laboratory scale. The investigation of the blood was carried out from the 35th or 48th day during the growing, period and also investigation of the internal organs – liver, heart, spleen, stomach, thymus, and bursa of Fabricius. The increase of cholesterol, triacylglycerols, and albumin in the blood of II, III, and VI chicken groups was established on the 35th day of the experiment, and the reduction of creatinine in III and VI groups. By that time, the effect of highest dose of I, Se, S caused a decrease in the T3 concentration in the blood of chickens in the VI group compared to the I and II groups. In particular, in the blood of chickens of IV, V and VI groups compared to the I, II, III group under these conditions there was a significant increase in the content of urea, Ca, P, cholesterol, as well as albumin – only in IV group on the 48th day. Triacylglycerols’ content increased in the blood serum of chickens in III and IV groups compared to the II and V groups, but in V group – decreased compared to the III, IV groups. The increase in liver, thymus, and heart mass in the II and V chicken groups was noticed and their decrease in the VI group was revealed compared with the control group. Reliable lower coefficients of the body mass of chickens of III and VI groups may indicate a less notable stimulating biological effect of I, Se, S citrate in these doses on liver development than on the whole organism. The addition of I, Se, S citrate to broiler chickens during the period of growing revealed the difference in their biological action in the presence and absence of the Kokcisan 12% in a mixed fodder. A more notable stimulating effect of low dose of I, Se, S citrate on the growth and development on the chickens' organism was established during the withdrawal of coccidiostatics from their diet. The effect may be due to its inhibitory influence on the biological activity of these elements in the first 35 days of growing. In the final period of chicken growing and withdrawal of ionophore Kokcisan from the diet more noticeable changes were revealed in the studied parameters.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological effects of iodine, selenium, sulfur citrates in broiler chickens

Fedoruk

Tesarivska

Kovalchuk

et al. 2021

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

show abstract

“…The IMPACT OF FEEDING MALE RATS F 2 WITH DIFFERENT DOSES OF GERMANIUM CITRATE biological role of these organo-compounds and their interaction with other macro-and trace elements and their impact on their distribution in the organism and its organs are actively studied as well. In particular, our earlier research [7,8] showed that the administration of germanium citrate, obtained via the erosive and explosive ablation with electro-impulse, caused a number of biological effects in the organism of rats. This may have found its cause in the fact that germanium (Ge) has an immuno-stimulating effect, enhances transport and transfer of Ɉ 2 and ensures the decrease of hypoxia at tissue level [3,4].…”

Section: Introductionmentioning

confidence: 99%

Impact of feeding male rats F2 with different doses of germanium citrate on the content of traceelements in their tissues and organs

Fedoruk¹,

Tesarivska²,

Khrabko³

et al. 2018

Agric. sci. pract.

Self Cite

View full text Add to dashboard Cite

Aim. To determine the impact of the dose of germanium citrate on the distribution of Fe, Zn, Cu, Co, Mn in tissues and organs of male F 2 rats. Methods. Physiological, biochemical, clinical, statistical. Results. It was established that there were changes in the content of Fe, Zn, Cu, Co, Mn in soft tissues and their distribution in liver, kidneys and lungs of male F 2 rats. It was demonstrated that these changes were mostly conditioned by organ-tissue specifi cities of functioning of some physiological systems of the organism, and less condition- ed – by the dose of germanium (10, 20 and 200 μg/kg of bodyweight). More vividly expressed changes in the content of these elements were established for kidneys at the effect of all the applied doses, and less express- ed – for liver and lungs. A positive impact of germanium citrate on the content of Cu, Co, Mn and Zn in the muscle tissues was determined at the effect of 10, 20 and 200 μg Ge, and as for Fe – 20 and 200 μg. The differences in the weight of liver, kidneys and lungs of rats of experimental and control groups were determined which eliminated the intergroup differences in the absolute content of the investigated microelements in liver, kidneys and lungs. The mentioned differences were more expressed for the absolute content of Cu in liver, Mn – in kidneys and lungs. Conclusions. Long-term introduction of germanium citrate into the organism of rats of generation F 2 with water in the amount of 10, 20 and 200 μg Ge/kg of the bodyweight is characterized by the changes in the content of Cu, Co, Mn, Fe, Zn both per one unit of soft tissue weight and their absolute content in the internal organs. The biological effect of germanium citrate is more expressed in the dose of 200 μg Ge/kg of the bodyweight, which conditions the increase in the content of Cu and Zn in all the investigated tissues of rats of this group at the background of the decreased level of Co in liver at the effect of 20 and 200 μg Ge, and at the effect of all the administered doses in kidneys and lungs. The level of Mn increased reliably in the muscle tissues of male F 2 rats at the effect of all the administered doses of Ge, Co 20 and 200 μg, Fe 10 and 20 μg, and Zn 10 and 200 μg Ge, which testifi es to the differences in the regulatory impact of NGeC on the level of investigated microelements in the muscle tissues of rats.

show abstract

“…In Ukraine, the number of thyroid diseases has almost doubled in recent deca des, which is associated with the lack of proper systemic prevention of iodine deficiency [3]. Therefore, in human nourishment and animal nutrition, salt, mineral, and organic iodine compounds are used to be added to water, various components of food and feed ration [4][5][6][7].…”

mentioning

confidence: 99%

The indices of thyroid system and metabolism of rats under the influence of nanocomposition based on iodine and citrate

Fedoruk¹,

Tesarivska²,

Kovalchuk³

et al. 2021

Ukr.Biochem.J

View full text Add to dashboard Cite

The search for a new biologically effective iodine compounds that may have practical use and do not cause toxic effects is relevant. The aim of the research was to examine the influence of nanocomposition based on citric acid -iodine helated compex (I 2 Citr) on the indices of thyroid system activity and metabolism in the blood serum of young male rats. Rats of the experimental groups received I 2 Citr with water daily for 40 days at a dose of 24 μg I/kg (1 st experimental group) and 240 μg I/kg (2 nd experimental group) of the body weight. The level of hormones and antibodies in the blood serum was determined with ELISA. Reduced Tg level and triacylglycerols content and elevated AntiTg, AntiTPO levels and Ca and albumin content in the serum of rats in both groups compared to control were observed. It was found that in the serum of rats in the 2 nd experimental group the levels of T3, T4 and urea, as well as the activity of alkaline phosphatase and AlAT were reduced. No changes in the coefficients of the rats internal organs mass were detected under the action of I 2 citr except for the spleen mass, which decreased by about 40% in the rats of 1 st group and by 33% -in rats of 2 nd group as compared to control. The data obtained indicate modulating influence of I 2 Citr in a studied doses on thyroid activity without causing toxic effects on animal organism. K e y w o r d s: nanocomposition basede on iodine and citrate, thyroid hormones, metabolic indices, internalorgans mass of rats.

show abstract

Biological efficiency of citrates of microelements in animal breeding

Cited by 7 publications

References 1 publication

Biological effects of iodine, selenium, sulfur citrates in broiler chickens

Biological effects of iodine, selenium, sulfur citrates in broiler chickens

Impact of feeding male rats F2 with different doses of germanium citrate on the content of traceelements in their tissues and organs

The indices of thyroid system and metabolism of rats under the influence of nanocomposition based on iodine and citrate

Contact Info

Product

Resources

About