Biological Evaluation of Dihydropyrimidinone Synthesized from Vanillin, Ethylacetoacetate and Urea using Gooseberry Extract

Abstract

Green chemistry approach is an eco-friendly approach which is used to prevent, or at least reduce pollution and has tremendous application in synthetic organic chemistry. This technique consists of an alternative reaction media to replace hazardous and expensive solvents consistently used in organic synthesis [1]. Green synthesis of organic compounds using solvent-free condition has gained popularity in recent years, since the majority of solvents are either toxic or flammable. Compared with conventional method the solvent free method is more convenient, simple to run, provide higher yield and shows maximum efficiency [2]. Recently fruit juice is known to be the potential organic solvent for the synthesis of pharmaceutically important organic compounds [3]. Fruit juices are used for various organic transformation reactions [4,5] and its widespread applications are due to their inexpensive, non-toxic, safe and environmentally benign nature [6]. Dihydropyrimidinones, the products of Biginelli reaction, are widely used in the pharmaceutical industries. Research has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. Dihydropyrimidinones and their derivatives show wide range of applications in natural, synthetic, pharmacological, therapeutic and

From traditional to greener alternatives: potential of plant resources as a biotransformation tool in organic synthesis

“…In light of the increasing significance of N-heterocycles, the Biginelli reaction was tested by employing a variety of bioresources ranging from Citrus maxima to coconut water and baker's yeast. [35][36][37][38][39][40][41][42][43][44][45] The reaction is often catalyzed by acids, but metals have been shown to catalyse the production of several bio-catalyst media. From Table 1, it was quite obvious that in the synthesis of 5-acetyl-4-(4-methoxyphenyl)-3,4dihydropyrimidin-2-(1H)-one, using bio-catalysts based on natural acids and enzymes can drive the reaction even under mild conditions, providing good yield compared to commonly used organic and inorganic catalysts like p-TsOH, RuCl 3 , etc.…”