Green chemistry approach is an eco-friendly approach which is used to prevent, or at least reduce pollution and has tremendous application in synthetic organic chemistry. This technique consists of an alternative reaction media to replace hazardous and expensive solvents consistently used in organic synthesis [1]. Green synthesis of organic compounds using solvent-free condition has gained popularity in recent years, since the majority of solvents are either toxic or flammable. Compared with conventional method the solvent free method is more convenient, simple to run, provide higher yield and shows maximum efficiency [2]. Recently fruit juice is known to be the potential organic solvent for the synthesis of pharmaceutically important organic compounds [3]. Fruit juices are used for various organic transformation reactions [4,5] and its widespread applications are due to their inexpensive, non-toxic, safe and environmentally benign nature [6]. Dihydropyrimidinones, the products of Biginelli reaction, are widely used in the pharmaceutical industries. Research has stimulated the invention of a wide range of synthetic methods for their preparation and chemical transformations. Dihydropyrimidinones and their derivatives show wide range of applications in natural, synthetic, pharmacological, therapeutic and