Biological markers in PAH exposed workers and controls

Hummelen, Paul Van; Gennart, J P; Buchet, Jean‐Pierre; Lauwerys, Robert; Kirsch‐Volders, Micheline

doi:10.1016/0165-1218(93)90055-i

Cited by 57 publications

(25 citation statements)

References 11 publications

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“…The urinary level of 1-Hydroxypyrene has the potential to be used as a biomarker for exposure to PAHs, and analytical methods for the detection of the hydroxy metabolite in urine of exposed and non-exposed control persons are available (Ariese et al 1993a;Mercado Calderon 1993;Van Hummelen et al 1993). The correlation coefficient between total PAHs in air of a coke production plant and hydroxypyrene in urine of workers was 0.77 (p<0.0001) (Mercado Calderon 1993 (Gorelick and Wogan 1989;Haugen et al 1986;Lau and Baird 1991;Phillips et al 1988;Weston and Bowman 1991).…”

Section: Identification Of Data Needsmentioning

confidence: 99%

“…Significant increases in urinary 1-hydroxypyrene levels have also been observed in children living in areas of high density automobile traffic over those of children in suburban areas . Several researchers have reported substantial increases in the urinary concentrations of 1-Hydroxypyrene and other PAH metabolites among workers exposed to PAHs in a variety of occupational settings, including coke plants (Grimmer et al 1994;Van Hummelen et al 1993), graphite electrode plants (Van Hummelen et al 1993), foundries (Santella et al 1993), and creosote wood treatment plants (Viau et al 1993) and during clean-up of dump sites contaminated with coal tars (Viau et al 1993), handling of petroleum coke , and road surfacing operations ).…”

Section: Potential For Human Exposurementioning

confidence: 99%

“…Thus, 1-Hydroxypyrene levels in urine may be used as a biomarker of exposure to PAHs in certain situations (Tolos et al 1990). Additional studies have evaluated the usefulness of determining PAH or metabolite levels in human urine as a measure of exposure in industrial and environmental exposure settings (Granella and Clonfero 1993;Hansen et al 1993;Herikstad et al 1993;Likhachev et al 1993;Ovrebo et al 1994;Santella et al 1993;Strickland et al 1994;Van Hummelen et al 1993;Van Rooij et al 1993a, 1993bViau et al 1993). Based on these results, the identification (Obana et al 1981).…”

Section: Health Effectsmentioning

confidence: 99%

“…The correlation coefficient between total PAHs in air of a coke production plant and hydroxypyrene in urine of workers was 0.77 (p<0.0001) (Mercado Calderon 1993 (Gorelick and Wogan 1989;Haugen et al 1986;Lau and Baird 1991;Phillips et al 1988;Weston and Bowman 1991). Chromosomal aberration and sister chromatid exchange methods were used to show that several types of cultured human tissue cells demonstrated positive results for benzo [a]pyrene-induced genotoxicity (Abe et al 1983a(Abe et al , 1983bHuh et al 1982;Lo Jacono et al 1992;Van Hummelen et al 1993;Weinstein et al 1977;Wienke et al 1990). However, statistically significant correlation between the cytogenetic markers and airborne occupational PAH levels was not found (Van Hummelen et al 1993).…”

Section: Identification Of Data Needsmentioning

confidence: 99%

“…Workers employed in a graphite electrode producing plant (n=16) and a coke oven (n=33) were compared to a control population of maintenance workers in a blast furnace (n=54) (Van Hummelen et al 1993). The concentration of PAHs in the environment was measured by personal air samplers, the concentration of hydroxypyrene in urine was measured, and smoking habits were evaluated.…”

Section: Inhalation Exposurementioning

confidence: 99%

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et al. 1998

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The aerial application of malathion over large urban populations in Southern California during the early 1990s raised concerns about adverse health effects, including the potential to cause genetic damage. Workers in the Mediterranean fruit fly eradication program, which involved application of malathion as ground treatment, were studied to examine micronucleus formation and mutation frequencies assessed by the glycophorin A (GPA) assay. In the 1992 pilot project the mean micronuclei level appeared higher in lymphocytes of exposed workers (n = 13) compared to controls (n = 4) (20.1 ± 7.1 vs 14.3 ± 7.2 respectively, P = 0.09). During the 1993 season, neither of the cohorts examined showed a higher level of micronuclei in workers exposed to malathion compared to unexposed, nor did the pooled total (n = 53; means = 17.8 ± 7.2 vs 18.5 ± 6.3, respectively), even after adjustment by multiple regression. The GPA variant frequency was not associated with malathion exposure in any of the cohorts. These results suggest that any potential risk of genotoxic damage from exposure to malathion is relatively low, but other assays may be more sensitive, and the sample size was small. Am. J. Ind. Med. 33:164‐174, 1998. © 1998 Wiley‐Liss, Inc.

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Cytogenetic biomonitoring in traffic police workers: Micronucleus test in peripheral blood lymphocytes

Bolognesi¹,

Merlo²,

Rabboni³

et al. 1997

Environ. Mol. Mutagen.

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Atmospheric pollution represents a relevant environmental hazard which has been associated with considerable excess mortality, morbidity, and increased rates of respiratory diseases in humans. To date, more than 3,000 environmental chemical compounds have been identified in the ambient atmosphere, including a variety of mutagenic and/or carcinogenic agents, such as polycyclic aromatic hydrocarbons (PAHs), aromatic amines, and heterocyclic compounds. Positive associations between cytogenetic markers and airborne levels of PAHs have been reported by experimental and human studies. Traffic has been implicated as the major determinant for the concentration of PAHs and, therefore, for the genotoxic activity of urban air. A biomonitoring study has been conducted in 82 Italian traffic police workers exposed to air pollutants and 34 control subjects (matched by age, gender, and smoking habits) not exposed to traffic pollutants. The aim of this study was to assess the cytogenetic effects, such as micronucleus frequency in peripheral blood lymphocytes, and to estimate the association with individual exposure to PAH. Statistical analysis of the frequency of micronuclei in binucleated cells showed higher mean levels in referent subjects (4.03%) than in traffic police officers (3.73%). Smoking showed no effect on the frequency of micronuclei. The study failed to detect any association between micronucleus frequency and individual level of benzo(a)pyrene, considered a marker of exposure to PAHs. These findings indicate that exposure to urban air pollutants does not result in increased levels of micronuclei in peripheral white blood cells. Environ. Mol. Mutagen. 30:396–402, 1997 © 1997 Wiley‐Liss, Inc.

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Biological markers in PAH exposed workers and controls

Cited by 57 publications

References 11 publications

The Gulf Oil Spill

The Gulf Oil Spill

Genetic monitoring of malathion-exposed agricultural workers

Cytogenetic biomonitoring in traffic police workers: Micronucleus test in peripheral blood lymphocytes

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