Biological monitoring of workers exposed to 4,4′-methylene-bis-(2-orthochloroaniline) (MOCA)

Robert, Alain; Ducos, P.; Francin, J. M.

doi:10.1007/s004200050366

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Interday accuracy and precision were 87.8−100.2% and 0.3−4.1%, respectively (Table 1). In comparison with the previously reported methods, the proposed method showed a similar LOD (GC-MS, 1 µ g/l; HPLC-UV, 1 µ g/l) 4,6) and LOQ (HPLC-ECD, 6.7 µ g/l; HPLC-MS/MS, 1 µ g/l) 7,8) .…”

Section: Validationsupporting

confidence: 50%

“…Therefore, we carried out hydrolysis according to the procedure employed in previous studies 5) . Several methods for determination of MBOCA in urine have been reported, including gas chromatography with mass spectrometry (GC-MS) 4,5) , high-performance liquid chromatography (HPLC) with ultraviolet detection (UV) 6) , electrochemical detection (ECD) 7) , and tandem mass spectrometry (MS/MS) 8) . The GC methods required a derivatization procedure with pentafluoropropionic anhydride.…”

Section: Sample Preparation and Gc-ecd Analysismentioning

confidence: 99%

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A Method for Routine Analysis of Urinary 4,4′‐methylenebis (2‐chloroaniline) by Gas Chromatography‐Electron Capture Detection

Takeuchi

Namera

Sakui

et al. 2014

Journal of Occupational Health

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A Method for Routine Analysis of Urinary 4,4‘‐methylenebis (2‐chloroaniline) by Gas Chroma‐tography‐Electron Capture Detection: Akito TAKEU‐CHI, et al. Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association— Objectives The purpose of this study was to develop a simple and cost‐effective method for the determination of urinary 4,4‘‐methylenebis (2‐chloroaniline) (MBOCA) by gas chromatography‐electron capture detection (GC‐ECD) for biological monitoring of occupational exposure to MBOCA. Methods MBOCA was prepared by liquidliquid extraction after alkaline hydrolysis, derivatized with N‐methyl‐bis (trifluoroacetamide) and then analyzed using GC‐ECD. The proposed method was validated in accordance with the US Food and Drug Administration guidance. Results The calibration curve showed linearity in the range 1–100 μg/l, with a correlation coefficient of >0.999. The limits of detection and quantification were 0.3 μg/l and 1 μg/l, respectively. The recovery was 94−99%. Intraday accuracy, expressed as the deviation from the nominal value, was 90.5−100.3%, and intraday precision, expressed as the relative standard deviation, was 0.3−2.4%. Interday accuracy and precision were 87.8−100.2% and 0.3−4.1%, respectively. Conclusions The proposed method is a simple and cost‐effective method suitable for routine analyses and could be useful for biological monitoring of occupational exposure to MBOCA.

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Section: Validationsupporting

confidence: 50%

Section: Sample Preparation and Gc-ecd Analysismentioning

confidence: 99%

A Method for Routine Analysis of Urinary 4,4′‐methylenebis (2‐chloroaniline) by Gas Chromatography‐Electron Capture Detection

Takeuchi

Namera

Sakui

et al. 2014

Journal of Occupational Health

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4,4′‐Methylen‐bis(2‐chloranilin) (MOCA) [BAT Value Documentation in German language, 2013]

Lämmlein¹

2014

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte), Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA), Biologische Leitwerte (BLW) und Biologische Arbeitsstoff‐Referenzwerte (BAR) , 20. Lieferung, Ausgabe 2013 Der Artikel enthält folgende Kapitel: Metabolismus und Toxikokinetik Kritische Toxizität Belastung und Beanspruchung Beziehung zwischen äußerer und innerer Belastung Beziehung zwischen innerer Belastung und Beanspruchung Auswahl der Indikatoren Untersuchungsmethoden Hintergrundbelastung Evaluierung

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Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress

et al. 2023

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Biological monitoring of workers exposed to 4,4′-methylene-bis-(2-orthochloroaniline) (MOCA)

Abstract: MOCA measured in sulfamic acid-protected urine samples without hydrolysis provides a more practical and reliable biomarker than "total" MOCA (after hydrolysis) or "free" MOCA. A biological guiding value of 20 micrograms/l expressed as "sulfamic acid-labile" MOCA is proposed.

Cited by 5 publications

References 25 publications

A Method for Routine Analysis of Urinary 4,4′‐methylenebis (2‐chloroaniline) by Gas Chromatography‐Electron Capture Detection

A Method for Routine Analysis of Urinary 4,4′‐methylenebis (2‐chloroaniline) by Gas Chromatography‐Electron Capture Detection

4,4′‐Methylen‐bis(2‐chloranilin) (MOCA) [BAT Value Documentation in German language, 2013]

Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress

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