Biological monitoring of workers exposed to acetone in acetate fibre plants.

Fujino, Akihiro; Sakurai, Toshihiko; Takebayashi, Tohru; Nakashima, Hiroshi; Higashi, Toshiaki; Matumura, Hiroshi; Minaguchi, Haruo; Kawai, Takeshi

doi:10.1136/oem.49.9.654

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…Fujino et al (1992) found a strong correlation (r=0.71) between exposure to acetone and acetone concentration in urine at the end of the shift, an acetone TWA of 500 ppm leading to a urinary concentration of about 50 mg/l (Table 8).…”

Section: Acetonementioning

confidence: 91%

Gases and organic solvents in urine as biomarkers of occupational exposure: a review

Imbriani

Ghittori

2004

Int Arch Occup Environ Health

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A brief review of urine analysis in studies of occupational exposure to volatile organic compounds and gases is provided. Analysis of exhaled breath for volatile compounds does not have a long history in occupational medicine. A number of studies has been undertaken since the 1980s, and the methods are well enough accepted to be put forward as biological equivalents of threshold limit values (TLVs) for some volatile organic compounds (VOCs) such as acetone; methanol; methyl ethyl ketone (MEK); methyl isobutyl ketone (MIBK); tetrahydrofurane; dichloromethane. In the last 20 years many scientific articles have shown that the urinary concentrations of unchanged solvents are correlated with environmental exposure and could be used for biological monitoring. The use of urine analysis of unchanged solvents in occupational applications is not yet widespread. Nonetheless, in the short time since its application, a number of important discoveries has been made, and the future appears bright for this branch of analysis. In this paper, the basic concepts and methodology of urine analysis are briefly presented with a critical revision of the literature on this matter. The excretion mechanisms of organic solvents in urine are discussed, with regard to biological variability, and the future directions of research are described.

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Section: Acetonementioning

confidence: 91%

Gases and organic solvents in urine as biomarkers of occupational exposure: a review

Imbriani

Ghittori

2004

Int Arch Occup Environ Health

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“…In these cases, the coincidental exposure to other chemicals could not be fully excluded and the exposures were usually, but not exclusively, followed by urinary excretion of acetone, as is done in acute cases as well [126][127][128][129]. When it is detected, breath acetone may be a useful tool in monitoring workers exposed to occupational hazards [130,131].…”

Section: Breath Acetone Measurementsmentioning

confidence: 99%

Breath acetone as a potential marker in clinical practice

Ruzsányi

Kalapos²

2017

J. Breath Res.

141

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In recent decades, two facts have changed the opinion of researchers about the function of acetone in humans. Firstly, it has turned out that acetone cannot be regarded as simply a waste product of metabolism, because there are several pathways in which acetone is produced or broken down. Secondly, methods have emerged making possible its detection in exhaled breath, thereby offering an attractive alternative to investigation of blood and urine samples. From a clinical point of view the measurement of breath acetone levels is important, but there are limitations to its wide application. These limitations can be divided into two classes, technical and biological limits. The technical limits include the storage of samples, detection threshold, standardization of clinical settings, and the price of instruments. When considering the biological ranges of acetone, personal factors such as race, age, gender, weight, food consumption, medication, illicit drugs, and even profession/class have to be taken into account to use concentration information for disorders. In some diseases such as diabetes mellitus and lung cancer, as well as in nutrition-related behavior such as starvation and ketogenic diet, breath acetone has been extensively examined. At the same time, there is a lack of investigations in other cases in which ketosis is also evident, such as in alcoholism or an inborn error of metabolism. In summary, the detection of acetone in exhaled breath is a useful and promising tool for diagnosis and it can be used as a marker to follow the effectiveness of treatments in some disorders. However, further endeavors are needed for clarification of the exact distribution of acetone in different body compartments and evaluation of its complex role in humans, especially in those cases in which a ketotic state also occurs. RECEIVED

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“…[23][24][25][26][27] Exposure to levels as low as 250 ppmv for 4 hours has been shown to lead to neurobehavioral effects, including increased aggression in males. [28] As such, monitoring exposure to acetone vapor and ensuring that it falls within safety guidelines is an important aspect of industrial hygiene.…”

Section: Discussionmentioning

confidence: 99%

Optical Acetone Vapor Sensors Based on Chiral Nematic Liquid Crystals and Reactive Chiral Dopants

Cachelin

Green

Peijs

et al. 2016

Advanced Optical Materials

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Accurate monitoring of exposure to organic vapors, such as acetone, is an important part of maintaining a safe working environment and adhering to long-and short-term exposure limits.Here, a novel acetone vapor detection system is described based on the use of a reactive chiral dopant in a nematic liquid crystal thin film, which can accurately monitor the total exposure over a given timeframe through changes in the reflection band of the film. It was found that films exposed to 1000 parts per million by volume (ppmv) of acetone vapor for two hours exhibited a shift in reflection band of 12 nm, with smaller shifts observed at lower concentrations of acetone. Such sensors have potential applications in industrial hygiene.

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Biological monitoring of workers exposed to acetone in acetate fibre plants.

Cited by 13 publications

References 15 publications

Gases and organic solvents in urine as biomarkers of occupational exposure: a review

Gases and organic solvents in urine as biomarkers of occupational exposure: a review

Breath acetone as a potential marker in clinical practice

Optical Acetone Vapor Sensors Based on Chiral Nematic Liquid Crystals and Reactive Chiral Dopants

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