Biological Properties and Prospects for the Application of Eugenol—A Review

Ulanowska, Magdalena; Olas, Beata

doi:10.3390/ijms22073671

Cited by 271 publications

(163 citation statements)

References 51 publications

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“…Eugenol has exhibited anticancer properties against several cancer types, such as leukemia, lung cancer, colon cancer, colorectal cancer, skin cancer, gastric cancer, breast cancer, cervical cancer, and prostate cancer [ 23 , 24 , 25 , 26 , 27 ] ( Table 1 ). Yoo et al assessed eugenol’s efficacy against human promyelocytic leukemia cells (HL-60).…”

Section: Eugenol Anticancer Propertiesmentioning

confidence: 99%

“…Moreover, it is presently recognized for its actions against several human cancer types, whereas it has insignificant toxicity towards normal cells. Several studies have displayed diverse molecular pathways for varied curative mechanisms of eugenol in the treatment of various cancer types [ 23 , 24 , 25 , 26 , 27 ]. Anticancer effects of eugenol are accomplished by various mechanisms like apoptosis induction, cell cycle arrest, inhibition of proliferation, migration, angiogenesis, and metastasis on several cancer cell lines [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Properties of Eugenol: A Review

2021

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Conventional cancer treatments have shown several unfavourable adverse effects, as well as an increase in anticancer drug resistance, which worsens the impending cancer therapy. Thus, the emphasis is currently en route for natural products. There is currently great interest in the natural bioactive components from medicinal plants possessing anticancer characteristics. For example, clove (Syzygium aromaticum L.) (Family Myrtaceae) is a highly prized spice that has been historically utilized as a food preservative and for diverse medical uses. It is reckoned amongst the valued sources of phenolics. It is indigenous to Indonesia but currently is cultivated in various places of the world. Among diverse active components, eugenol, the principal active component of S. aromaticum, has optimistic properties comprising antioxidant, anti-inflammatory, and anticancer actions. Eugenol (4-allyl-2-methoxyphenol) is a musky oil that is mainly obtained from clove. It has long been utilized all over the world as a result of its broad properties like antioxidant, anticancer, anti-inflammatory, and antimicrobial activities. Eugenol continues to pique investigators’ interest because of its multidirectional activities, which suggests it could be used in medications to treat different ailments. Anticancer effects of eugenol are accomplished by various mechanisms like inducing cell death, cell cycle arrest, inhibition of migration, metastasis, and angiogenesis on several cancer cell lines. Besides, eugenol might be utilized as an adjunct remedy for patients who are treated with conventional chemotherapy. This combination leads to a boosted effectiveness with decreased toxicity. The present review focuses on the anticancer properties of eugenol to treat several cancer types and their possible mechanisms.

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Section: Eugenol Anticancer Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Eugenol: A Review

2021

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“…The human body has many defense mechanisms that neutralize the harmful effects of reactive oxygen species. Antioxidants play an important role in reducing oxidative damage in the human body [1][2][3][4][5]. These are compounds which, even at a very low concentration, compared to the substrate, can delay or prevent its oxidation.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Antioxidant Activity and Ligand Basicity in the Dipicolinate Series of Oxovanadium(IV) and Dioxovanadium(V) Complexes

Drzeżdżon

Pawlak

Matyka

et al. 2021

IJMS

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Oxidative stress plays an important role in the pathogenesis of many serious diseases, including cancer, atherosclerosis, coronary artery disease, Parkinson’s disease, Alzheimer’s disease, stroke and myocardial infarction. In the body’s natural biochemical processes, harmful free radicals are formed, which can be removed with the help of appropriate enzymes, a balanced diet or the supply of synthetic antioxidant substances such as flavonoids, vitamins or anthocyanins to the body. Due to the growing demand for antioxidant substances, new complex compounds of transition metal ions with potential antioxidant activity are constantly being sought. In this study, four oxovanadium(IV) and dioxovanadium(V) dipicolinate (dipic) complexes with 1,10-phenanthroline (phen), 2,2′-bipyridyl (bipy) and the protonated form of 2-phenylpyridine (2-phephyH): (1) [VO(dipic)(H2O)2] · 2 H2O, (2) [VO(dipic)(phen)] · 3 H2O, (3) [VO(dipic)(bipy)] · H2O and (4) [VOO(dipic)](2-phepyH) · H2O were synthesized including one new complex, so far unknown and not described in the literature, i.e., [VOO(dipic)](2-phepyH) · H2O. The oxovanadium(IV) dipicolinate complexes with 1,10-phenanthroline and 2,2′-bipyridyl have been characterized by several physicochemical methods: NMR, MALDI-TOF-MS, IR, but new complex [VOO(dipic)](2-phepyH) · H2O has been examined by XRD to confirm its structure. The antioxidant activities of four complexes have been examined by the nitrotetrazolium blue (NBT) method towards superoxide anion. All complexes exhibit high reactivity with superoxide anion and [VOO(dipic)](2-phepyH) · H2O has higher antioxidant activity than L-ascorbic acid. Our studies confirmed that high basicity of the auxiliary ligand increases the reactivity of the complex with the superoxide radical.

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“…Eugenol (4-allyl-2-methoxyphenol) is the major component of clove essential oils, but it can be also found in minor amounts in cinnamon, clover pepper and other plants. It is used in perfumeries for its pleasant fragrance, as a flavoring agent in foods, as antiseptic and disinfectant in dental products and in many other fields [ 169 ]. Eugenol can be readily functionalized through the chemical transformation of the phenolic -OH group (mainly via the classical etherification and esterification reactions) [ 170 , 171 , 172 , 173 , 174 , 175 , 176 ], on the aromatic ring (through nitration reaction or Mannich bases formation) [ 177 , 178 , 179 , 180 ], as well as on the allylic functionality, through epoxidation [ 175 ] ( Figure 2 ).…”

Section: Monophenolsmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

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Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.

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Biological Properties and Prospects for the Application of Eugenol—A Review

Cited by 271 publications

References 51 publications

Anticancer Properties of Eugenol: A Review

Anticancer Properties of Eugenol: A Review

Relationship between Antioxidant Activity and Ligand Basicity in the Dipicolinate Series of Oxovanadium(IV) and Dioxovanadium(V) Complexes

Tailored Functionalization of Natural Phenols to Improve Biological Activity

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