The review provides an analysis of the current literature data on the prevalence of weeds of the Asteraceae and Malvaceae families, which act as reservoirs of agricultural plant viruses, in the agroecosystems of both Ukraine and the world. The main focus is on weeds that are common in the agrocenoses of agricultural crops. The primary sources of the main pathogens of viral diseases of vegetable crops (Tomato spotted wilt virus (TSWV), Tomato chlorosis virus (ToCV), Tomato yellow leaf curl virus (TYLCV), Cucumber mosaic virus (CMV), Cucumber vein yellowing virus (CVYV), Iris yellow spot virus (IYSV), and Pepino mosaic virus (PepMV)) in different climatic zones, as well as the main factors contributing to the spread of harmful viruses in agrophytocenoses are analyzed.