Biological, Psychological, and Social Predictors of Longevity Among Utah Centenarians

Yorgason, Jeremy B.; Draper, Thomas W.; Bronson, H.; Nielson, Makayla; Babcock, Kate; Jones, Karolina; Hill, Melanie S.; Howard, Myranda

doi:10.1177/0091415018757211

Cited by 9 publications

(9 citation statements)

References 45 publications

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“…Health behaviors related to improvements in HRV are similar to those that characterize the lifestyle of centenarians in different populations: regular physical activity, dietary habits, no drinking, and no smoking (Ozaki et al, 2007;Kim et al, 2012;Wu et al, 2017). But psychological moments are also a key element in the NIACT framework, and in the same way, active engagement in community activities, high levels of self-perceived well-being, and satisfaction with life are defining elements of the centenarian population (Ozaki et al, 2007;Kim et al, 2012;Wu et al, 2017;Hitchcott et al, 2018;Yorgason et al, 2018). Therefore, the characteristic lifestyle of centenarians would imply a greater resilience, indexed by greater variability of the HR and, as described above, higher SDNN values would mean better survival prognosis in centenarians.…”

Section: Centenarians and The "Neurovisceral Integration Across A Conmentioning

confidence: 96%

Heart Rate Variability and Exceptional Longevity

et al. 2020

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Section: Centenarians and The "Neurovisceral Integration Across A Conmentioning

confidence: 96%

Heart Rate Variability and Exceptional Longevity

et al. 2020

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“…The most obvious explanation of these differences is that socio-economic status impacts on nutritional profile, stress and exposure to infections, but recent data showed that epigenetic modifications (and in particular DNA methylation) may "recode" information of the father's environmental exposure and then be transmitted to the offspring [105][106][107] , supporting the crucial role of evaluating these factors for the missing heritability. Moreover, it has been suggested that -even if social interactions tend to reduce during aging -the maintenance of social connections help to live longer 108 and is associated with lower mortality.…”

Section: The Genetics Of Longevity In Different Socio-economic Settingsmentioning

confidence: 99%

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Giuliani

Garagnani

Franceschi

2018

Circulation Research

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Genetics of human longevity within an eco-evolutionary nature-nurture framework. -Circulation Research 2018 ; 123(7) : 745-772.The final published version is available online at: https://www.ahajournals.org/ ABSTRACTHuman longevity is a complex trait, and to disentangle its basis has a great theoretical and practical consequence for biomedicine. The genetics of human longevity is still poorly understood, despite a number of investigations that used different strategies and protocols. Here we argue that such rather disappointing harvest is largely due to the extraordinary complexity of the longevity phenotype in humans. The capability to reach the extreme decades of human lifespan appears to be the result of an intriguing mixture of geneenvironment interactions. Accordingly, the genetics of human longevity is here described as a highly context-dependent phenomenon, within a new integrated, ecological and evolutionary perspective, and is presented as a dynamic process, both historically and individually. The available literature has been scrutinized within this perspective, paying particular attention to factors (sex, individual biography, family, population ancestry, social structure, economic status and education, among others) that have been relatively neglected. The strength and limitations of the most powerful and used tools, such as GWAS and whole-genome sequencing, have been discussed, focusing on prominently emerged genes and regions, such as APOE, FOXO3, IL-6, IGF-1, chromosome 9p21, 5q33.3 and somatic mutations among others. The major results of this approach suggest that: i) the genetics of longevity is highly population-specific; ii) small-effect alleles, pleiotropy and the "complex allele timing" likely play a major role; iii) genetic risk factors are age-specific and need to be integrated in the light of the geroscience perspective; iv) a close relationship between genetics of longevity and genetics of age-related diseases (especially cardiovascular diseases) do exist. Finally, the urgent need of a global approach to the largely unexplored interactions between the three genetics of human body, i.e. nuclear, mitochondrial and microbiomes, is stressed. We surmise that the comprehensive approach here presented will help in increasing the above-mentioned harvest.

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“…In a unique study on centenarians, data were collected from 268 family members [41]. Sleep onset latency along with life satisfaction and attachment closeness were contributors to the number of days lived.…”

Section: Early Mortalitymentioning

confidence: 99%

Sleep Problems in Aging (Ageing) Adults: A Narrative Review

2023

Int J Geriatr Gerontol

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The recent literature on sleep problems in aging (ageing) adults has primarily focused on negative effects as well as risk factors, buffers, and interventions. The sleep problems have typically been self-reported or measured by actigraphy. The prevalence rates for sleep problems starting at age 60 have been variable, ranging from a low of 18% in the UK to a high of 50% in China, a variability that may relate to the type of sleep data and/or cross-cultural variation. Psychological effects have included dissatisfaction with life, unhealthy aging and affective/depressive mood states. Physical effects have included elevated blood pressure, impaired functionality, frailty, comorbidity and immune dysfunction. Cognitive impairment has also resulted from sleep problems, and aging brain biomarkers have included shorter telomere length, reduced gray matter volume and earlier mortality. Psychological risk factors have included meta-cognitive beliefs, worrying, loneliness, poor relationships and depression. Physical risk factors have included inactivity, napping and comorbidity. Buffers/protective factors have included retirement, light exercise, consumption of vegetables and melatonin as a sleep medication. Only a couple interventions could be found in this recent literature on sleep in aging adults including Cognitive Behavior Therapy and exercise. A few potential underlying mechanisms for disturbed sleep in aging adults include decreased vagal activity, increased connectivity in the brain making disconnecting for sleep difficult, inflammation and orexins. Although the data highlight the severity of sleep problems in the aging, they have been primarily based on self-report surveys that have yielded mixed results across samples. Sleep Problems in Aging (Ageing) Adults: A Narrative ReviewThis narrative review involved entering the terms sleep and aging (ageing) into PubMed and PsycINFO. The search yielded 735 papers for the last five years. However, following exclusion criteria including case studies and non-English language papers, this review is a summary of the research reported in 67 papers. The recent literature is predominantly focused on negative effects of sleep problems along with studies on risk factors, buffers and interventions. This narrative review is accordingly divided into sections on prevalence of sleep problems in the aging, negative effects, risk factors, buffers and interventions. These are followed by sections on potential underlying mechanisms for sleep problems in the aging and methodological limitations of the research.

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Biological, Psychological, and Social Predictors of Longevity Among Utah Centenarians

Cited by 9 publications

References 45 publications

Heart Rate Variability and Exceptional Longevity

Heart Rate Variability and Exceptional Longevity

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Sleep Problems in Aging (Ageing) Adults: A Narrative Review

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