Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

Umehara, Yui; Kageyama, Toki; Son, Aoi; Kimura, Yu; Kondo, Teruyuki; Tanabe, Kazuhito

doi:10.1039/c9ra00951e

Cited by 12 publications

(12 citation statements)

References 47 publications

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“…Umehara et al [ 169 ] modified the AuNRs with 2-nitroimidazole derivatives (NIs) (G-NIs) to detect tumor hypoxia in vivo by PAI. They used colon 26 cancer cells (CT26) that were transplanted into mice and injected them intravenously with G-NIs.…”

Section: Functionalized Aunps For Cancer Therapymentioning

confidence: 99%

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

et al. 2023

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The conventional methods of cancer treatment and diagnosis, such as radiotherapy, chemotherapy, and computed tomography, have developed a great deal. However, the effectiveness of such methods is limited to the possible failure or collateral effects on the patients. In recent years, nanoscale materials have been studied in the field of medical physics to develop increasingly efficient methods to treat diseases. Gold nanoparticles (AuNPs), thanks to their unique physicochemical and optical properties, were introduced to medicine to promote highly effective treatments. Several studies have confirmed the advantages of AuNPs such as their biocompatibility and the possibility to tune their shapes and sizes or modify their surfaces using different chemical compounds. In this review, the main properties of AuNPs are analyzed, with particular focus on star-shaped AuNPs. In addition, the main methods of tumor treatment and diagnosis involving AuNPs are reviewed.

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Section: Functionalized Aunps For Cancer Therapymentioning

confidence: 99%

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

et al. 2023

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“…Several design strategies have been employed to develop PA probes to visualize tumor hypoxia. 183,208,310–323…”

Section: Activatable Pa Probesmentioning

confidence: 99%

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

2022

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“…Gold nanorods have also been used as PA probes (AuNRs) since they have a strong absorbance in the NIR spectrum and good biocompatibility. Umehara et al used AuNRs that contain nitroimidazole units on their surface to identify areas of hypoxia in xenograft tumors [ 82 ]. In summary, PAI is minimally invasive, which makes it promising for future clinical use.…”

Section: Detection Of Hypoxia In Vivomentioning

confidence: 99%

Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances

Godet

Doctorman

et al. 2022

Cells

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The rapid proliferation of cancer cells combined with deficient vessels cause regions of nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme hypoxic conditions and persist to promote cancer progression. Intratumoral hypoxia has been consistently associated with a worse patient prognosis. In vitro, 3D models of spheroids or organoids can recapitulate spontaneous O2 gradients in solid tumors. Likewise, in vivo murine models of cancer reproduce the physiological levels of hypoxia that have been measured in human tumors. Given the potential clinical importance of hypoxia in cancer progression, there is an increasing need to design methods to measure O2 concentrations. O2 levels can be directly measured with needle-type probes, both optical and electrochemical. Alternatively, indirect, noninvasive approaches have been optimized, and include immunolabeling endogenous or exogenous markers. Fluorescent, phosphorescent, and luminescent reporters have also been employed experimentally to provide dynamic measurements of O2 in live cells or tumors. In medical imaging, modalities such as MRI and PET are often the method of choice. This review provides a comparative overview of the main methods utilized to detect hypoxia in cell culture and preclinical models of cancer.

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Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

Abstract: Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging.

Cited by 12 publications

References 47 publications

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

Cancer Treatment Using Different Shapes of Gold-Based Nanomaterials in Combination with Conventional Physical Techniques

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances

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