Biological Sources of Nerve Growth Factor

Murphy, Richard A.; Watson, Ann Y.; Rhodes, James A.

doi:10.1159/000101200

Cited by 13 publications

(20 citation statements)

References 31 publications

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“…Several species, including humans, exhibit a relative abundance of NGF within the prostate (10,11). Prostate tissue derived from normal, benign prostatic hyperplasia and adenocarcinoma specimens has indicated that NGF immunoreactive protein is localized in the stromal compartment (12).…”

Section: Discussionmentioning

confidence: 99%

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Huang

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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Nerve growth factor (NGF) has been found in the normal prostate of the Wistar rat and is regarded as an important prostatic mitogen. We have previously shown that chronic stress induced epithelial hyperplasia while sympathetic denervation caused atrophy in the male Wistar rat prostate. NGF may have been a contributing mechanism to the hyperplasia and atrophy response that was observed. The aim of the present study was to investigate the expression of NGF in the prostate of the male rat in response to chronic stress and denervation. Two weeks of restraint water-immersion stress were used to induce a chronic stress model in Wistar rats. Denervation of the peripheral sympathetic nerve was induced by 6-hydroxydopamine. The expression levels of NGF in the dissected prostate lobes were examined by immunohistochemistry. After 14 days of stress, proliferation of the epithelium in the ventral lobes was observed, whereas the dorsolateral lobes were almost unaffected. NGF immunoreactive protein was localized to the columnar secretory epithelium lines of the prostate tissue. Stress and denervation led to an increase in NGF expression in the ventral lobes. In conclusion, NGF was involved in the hyperplasia and atrophy in the prostate of the male rat in response to chronic stress and sympathetic denervation, and thus may be a contributing factor in the pathophysiology of the prostate.

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Section: Discussionmentioning

confidence: 99%

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Huang

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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“…Early immunofluorescence histochemical studies localized NGF to GCT cells in mice (Goldstein and Burdman, 1965;Kumar et al, 1972;Levi-Montalcini, 1964;Levi-Montalcini and Angeletti, 1961). Improvements in immunofluorescence techniques (Murphy et al, 1984;Rush, 1984) and the application of immunoperoxidase methods (Aloe et al, 1985;Hazen-Martin and Simson, 1984;Hofmann and Drenckhahn, 1981;Simson et al, 1978) confirmed and refined these localizations. Initial fine structural immunocytochemical studies were unsatisfactory (Schwab et al, 19761, but eventually immunogold (Kusakabe et al, 1986;Watson et al, 1985) and immunoperoxidase (Hazan-Martin and Simson, 1987) methods established that the principal site of NGF is the apical secretion granules.…”

Section: Ngfmentioning

confidence: 95%

The granular convoluted tubule (GCT) cell of rodent submandibular glands

Gresik¹

1994

Microscopy Res & Technique

175

183

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The granular convoluted tubule (GCT) is a segment of the duct system of all rodents, situated between the striated and intercalated ducts. It has the peculiar property of synthesizing a large variety of biologically active polypeptides whose role in saliva remains unknown. The literature on the fine structure of GCT cells is critically reviewed. Some recent developments on endocrine regulation of the structure and contents of rodent GCT cells are summarized, with emphasis on EGF, NGF, renin, and kallikrein proteases. A survey of the distribution of GCT cells in several vertebrate families is presented.

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“…After the central nervous system the human prostate is the next most abundant source of NGF [96], where it plays a role in normal prostate development [97]. Stromal cells secrete NGF which binds to TrkA and p75 NTR present on prostate epithelial cells stimulating their growth [98-100].…”

Section: Ngf Signaling In Cancersmentioning

confidence: 99%

Nerve Growth Factor in Cancer Cell Death and Survival

Molloy

Read

Gorman

2011

Cancers

104

103

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One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to pro-survival signaling in many different types of cancer. In particular, nerve growth factor, the archetypal neurotrophin, has been shown to play a role in tumorigenesis over the past decade. Nerve growth factor mediates its effects through its two cognate receptors, TrkA, a receptor tyrosine kinase and p75NTR, a member of the death receptor superfamily. Depending on the tumor origin, pro-survival signaling can be mediated by TrkA receptors or by p75NTR. For example, in breast cancer the aberrant expression of nerve growth factor stimulates proliferative signaling through TrkA and pro-survival signaling through p75NTR. This latter signaling through p75NTR promotes increased resistance to the induction of cell death by chemotherapeutic treatments. In contrast, in prostate cells the p75NTR mediates cell death and prevents metastasis. In prostate cancer, expression of this receptor is lost, which contributes to tumor progression by allowing cells to survive, proliferate and metastasize. This review focuses on our current knowledge of neurotrophin signaling in cancer, with a particular emphasis on nerve growth factor regulation of cell death and survival in cancer.

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Biological Sources of Nerve Growth Factor

Cited by 13 publications

References 31 publications

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

The granular convoluted tubule (GCT) cell of rodent submandibular glands

Nerve Growth Factor in Cancer Cell Death and Survival

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