Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Huang, Shiyuan; Zhang, Xuebei; Xu, Liuyu; Li, Qing; Zhao, Qing‐Li

doi:10.3892/etm.2014.1856

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…At the same time, the widespread distribution of NGF and its mRNA confirms that the prostate of rabbits is the main source of this neurotrophin for the seminal plasma, as already demonstrated in several other species, including humans (Arrighi et al 2010). A specific mitogenic action of NGF has also been reported in the prostate of rats (Huang et al 2014). Thus, our findings indirectly support results from recent experiments using seminal plasma of different species and indicate that the ovulation-inducing factor NGF is much more abundant in rabbits than in bulls, horses and pigs.…”

Section: Discussionsupporting

confidence: 71%

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Gene Expression and Localization of NGF and Its Cognate Receptors NTRK1 and NGFR in the Sex Organs of Male Rabbits

Maranesi

Zerani

Leonardi

et al. 2015

Reprod Domestic Animals

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Experiments were devised to characterize the expression of nerve growth factor, beta polypeptide (NGF), and its cognate receptors neurotrophic tyrosine kinase receptor type 1 (NTRK1) and nerve growth factor receptor (NGFR) in rabbit male sex organs, as well as the concentrations of NGF in both seminal and blood plasma of sexually mature male rabbits. Immunoreactivity and gene expression for NGF and cognate receptors were detected in testis, prostate gland and seminal vesicle. The highest levels of NGF and NTRK1 transcripts were found in the prostate, while intermediate expressions were found in the testis. NGFR transcripts were expressed at the same levels in both testis and prostate and were more abundant than in seminal vesicles. The widespread distribution of NGF in all prostate glandular cells, together with its relative high mRNA abundance, confirms that the prostate of rabbits is the main source of this neurotrophin. In conclusion, the present data suggest that the NGF system is involved in the testicular development and spermatogenesis of rabbits and that NGF may act as a potential ovulation-inducing factor being abundantly present in the seminal plasma.

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Section: Discussionsupporting

confidence: 71%

“…A specific mitogenic action of NGF has also been reported in the prostate of rats (Huang et al. ). Thus, our findings indirectly support results from recent experiments using seminal plasma of different species and indicate that the ovulation‐inducing factor NGF is much more abundant in rabbits than in bulls, horses and pigs.…”

Section: Discussionmentioning

confidence: 83%

Gene Expression and Localization of NGF and Its Cognate Receptors NTRK1 and NGFR in the Sex Organs of Male Rabbits

Maranesi

Zerani

Leonardi

et al. 2015

Reprod Domestic Animals

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“…Sympathetic hyper-innervation also charges for the pathogenesis of BPH, which could result in ventral prostate hyperplasia (22). Moreover, nerve growth factor is involved in the pathogenesis of BPH in response to sympathetic hyper-innervation (23). In our study, not only storage LUTS but also voiding LUTS was significantly related with sodium intake.…”

Section: Discussionsupporting

confidence: 48%

Association between sodium intake and lower urinary tract symptoms: does less sodium intake have a favorable effect or not?

et al. 2020

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Background: Sodium intake is known to be related with hypertension (HTN), which could impact lower urinary tracts symptoms (LUTS) indirectly. To date, only limited clinical evidences exist upon the association between sodium preference and LUTS. This cross-sectional study analyzed the association between sodium preference and the severity of LUTS in men.Methods: A cross-sectional analysis has been performed and a total of 86,637 participants among total registered population of 229,226 in Korean Community Health Survey (KCHS) were included for final analysis. The adjusted odds ratio (OR) or coefficient with 95% confidence interval (CI) estimates were described to show the association between sodium preference and LUTS using negative binomial regression (for the IPSS total, IPSS voiding, and IPSS storage symptoms), ordinal logistic regression (for the IPSS grade), and binomial logistic regression (for the IPSS nocturia symptoms).Results: Preference of salty taste group (high sodium preference) were significantly associated with higher IPSS total score (Coef =0.31; 95% CI: 0.27, 0.35), increased risk of severe IPSS grade (OR =1.46; 95% CI: 1.35, 1.57), higher IPSS voiding score (Coef =0.38; 95% CI: 0.32, 0.44), higher IPSS storage score (Coef =0.25; 95% CI: 0.22, 0.29), and increased risk of having IPSS nocturia symptoms (OR =1.21; 95% CI: 1.16, 1.27) compared to subjects with neutral group (normal sodium preference). Prediction of IPSS score according to salty taste preference showed u shaped distribution.Conclusions: Sodium preference for taste were significantly associated with LUTS including voiding symptom, storage symptom and nocturia. Both higher and lower intake of sodium could be unfavorable factor for severity of LUTS.

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“…Our results demonstrate that restraint stress (both acute and chronic) is sufficient to alter the expression of genes associated with tumor proliferation and metastasis in the rat prostate. Previous studies using a rat model of chronic stress (by restraint water immersion) have shown that 14 days of stress can induce histological changes in the prostate, as well as proliferation of epithelial cells of the ventral lobe of the prostate [ 53 , 54 ]. Although the expression of proliferation-associated genes was not measured in these studies, our data supports the notion that restraint stress can induce aberrant gene expression, which could potentially lead to increased cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Stress alters the expression of cancer-related genes in the prostate

et al. 2017

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BackgroundProstate cancer is a major contributor to mortality worldwide, and significant efforts are being undertaken to decipher specific cellular and molecular pathways underlying the disease. Chronic stress is known to suppress reproductive function and promote tumor progression in several cancer models, but our understanding of the mechanisms through which stress contributes to cancer development and progression is incomplete. We therefore examined the relationship between stress, modulation of the gonadotropin-releasing hormone (GnRH) system, and changes in the expression of cancer-related genes in the rat prostate.MethodsAdult male rats were acutely or repeatedly exposed to restraint stress, and compared to unstressed controls and groups that were allowed 14 days of recovery from the stress. Prostate tissue was collected and frozen for gene expression analyses by PCR array before the rats were transcardially perfused; and brain tissues harvested and immunohistochemically stained for Fos to determine neuronal activation.ResultsAcute stress elevated Fos expression in the paraventricular nucleus of the hypothalamus (PVH), an effect that habituated with repeated stress exposure. Data from the PCR arrays showed that repeated stress significantly increases the transcript levels of several genes associated with cellular proliferation, including proto-oncogenes. Data from another array platform showed that both acute and repeated stress can induce significant changes in metastatic gene expression. The functional diversity of genes with altered expression, which includes transcription factors, growth factor receptors, apoptotic genes, and extracellular matrix components, suggests that stress is able to induce aberrant changes in pathways that are deregulated in prostate cancer.ConclusionsOur findings further support the notion that stress can affect cancer outcomes, perhaps by interfering with neuroendocrine mechanisms involved in the control of reproduction.Electronic supplementary materialThe online version of this article (10.1186/s12885-017-3635-4) contains supplementary material, which is available to authorized users.

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Expression of nerve growth factor in the prostate of male rats in response to chronic stress and sympathetic denervation

Cited by 8 publications

References 19 publications

Gene Expression and Localization of NGF and Its Cognate Receptors NTRK1 and NGFR in the Sex Organs of Male Rabbits

Gene Expression and Localization of NGF and Its Cognate Receptors NTRK1 and NGFR in the Sex Organs of Male Rabbits

Association between sodium intake and lower urinary tract symptoms: does less sodium intake have a favorable effect or not?

Stress alters the expression of cancer-related genes in the prostate

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