Biological synthesis and characterization of gold nanoparticles using Verbascum speciosum Schrad. and cytotoxicity properties toward HepG2 cancer cell line

Kouhi, Seyed Mousa Mousavi; Beyk-Khormizi, Abdollah; Mohammadzadeh, Vahideh; Ashna, Mohammad; Es‐haghi, Ali; Mashreghi, Mohammad; Hashemzadeh, Vahideh; Mozafarri, Hamid; Nadaf, Mohabat; Yazdi, Mohammad Ehsan Taghavizadeh

doi:10.1007/s11164-021-04600-w

Cited by 45 publications

(18 citation statements)

References 52 publications

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“…Improvement of hydrophobicity and bioavailability of Res; 2. The beneficial effects of Au NPs, as they contain specific anti-inflammatory, anti-bacterial, and other pharmacological effects and are widely used in drug delivery and non-viral gene delivery [ 25 , 26 ]. These results suggested that RGNPs had excellent pharmacological effects and transformative potential.…”

Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Chen

Liu

et al. 2022

Pharmaceuticals

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Nanoparticle-based drug delivery systems, which can overcome the challenges associated with poor aqueous solubility and other harmful side effects of drugs, display potent applications in cataract treatment. Herein, we designed a nanosystem of gold nanoparticles containing resveratrol (RGNPs) as an anti-aging agent to delay cataracts. The spherical RGNPs had a superior ability to inhibit hydrogen peroxide-mediated oxidative stress damage, including reactive oxygen species (ROS) production, malondialdehyde (MDA) generation, and glutathione (GSH) consumption in the lens epithelial cells. Additionally, the present data showed that RGNPs could delay cellular senescence induced by oxidative stress by decreasing the protein levels of p16 and p21, reducing the ratio of BAX/BCL-2 and the senescence-associated secretory phenotype (SASP) in vitro. Moreover, the RGNPs could also clearly relieve sodium selenite-induced lens opacity in a rat cataract model. Our data indicated that cell senescence was reduced and cataracts were delayed upon treatment with RGNPs through activating the Sirt1/Nrf2 signaling pathway. Our findings suggested that RGNPs could serve as an anti-aging ingredient, highlighting their potential to delay cataract development.

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Section: Discussionmentioning

confidence: 99%

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Chen

Liu

et al. 2022

Pharmaceuticals

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“…The nanoparticles demonstrated dose-dependent cell viability against cancer cells by inducing apoptosis, with half inhibitory concentration (IC50) values of 10 g/mL [192]. In another study, Mousavi-Kouhi et al, 2022, synthesized gold nanoparticles from Verbascum speciosum; the green synthesized AuNPs were about 118 ± 72 nm in size and very effective against the hepatocellular carcinoma cell line (HepG2) and pathogenic bacteria [193].…”

Section: Biological and Theranostic Applicationsmentioning

confidence: 99%

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Muddapur

Alshehri

Ghoneim³

et al. 2022

Molecules

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Bionanotechnology is a branch of science that has revolutionized modern science and technology. Nanomaterials, especially noble metals, have attracted researchers due to their size and application in different branches of sciences that benefit humanity. Metal nanoparticles can be synthesized using green methods, which are good for the environment, economically viable, and facilitate synthesis. Due to their size and form, gold nanoparticles have become significant. Plant materials are of particular interest in the synthesis and manufacture of theranostic gold nanoparticles (NPs), which have been generated using various materials. On the other hand, chemically produced nanoparticles have several drawbacks in terms of cost, toxicity, and effectiveness. A plant-mediated integration of metallic nanoparticles has been developed in the field of nanotechnology to overcome the drawbacks of traditional synthesis, such as physical and synthetic strategies. Nanomaterials′ tunable features make them sophisticated tools in the biomedical platform, especially for developing new diagnostics and therapeutics for malignancy, neurodegenerative, and other chronic disorders. Therefore, this review outlines the theranostic approach, the different plant materials utilized in theranostic applications, and future directions based on current breakthroughs in these fields.

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“…Another study utilizing bovine serum albuminbound resveratrol NPs in primary ovarian cancer of mice showed that not only the NP-bound resveratrol was easier to work with because of the improved solubility, it had also a greater influence on prevent of tumor growth, compared to pure resveratrol [52]. The anti-cancer effect of gold nanoparticles against breast, testicular, liver, and lung cancer cells has been proven in a concentration-dependent manner [30,[51][52][53][54][55]. In another study, the produced gold nanoparticles provided a safe and great system for the delivery of gapmers in cancerous cells, which meaningfully down-regulated mutant p53 proteins and changed molecular markers related to cell growth and apoptosis [56].…”

Section: Anticancer Properties Of Ncmentioning

confidence: 99%

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

Ghorani‐Azam¹,

Mottaghipisheh²,

Amiri³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions. Methods: The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential. Results: The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2). Conclusions: The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further in vivo investigations is proposed to be designed to assess anti-cancer and safety effects of fabricated nanocomposites.

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Biological synthesis and characterization of gold nanoparticles using Verbascum speciosum Schrad. and cytotoxicity properties toward HepG2 cancer cell line

Cited by 45 publications

References 52 publications

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

Plant-Based Synthesis of Gold Nanoparticles and Theranostic Applications: A Review

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

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