In this paper, a survey of new achievements in the area of biologically inspired design and manufacturing and fundamental rules of biological transformation in manufacturing – also in relation to mechanical engineering – is provided. Some possible scenarios and several examples of the applications of biological transformation in manufacturing are presented. Some new trends, for instance, the way so-called Living Manufacturing Systems, which are based on advanced AI techniques, are discussed. Finally, some examples of a successful biologicalisation of manufacturing tools, i.e. injection moulds, machine tools, manufacturing processes, and systems are provided. This paper can motivate Polish engineers and researchers to undertake this topic in Poland.