After bench-and pilot-scale studies demonstrated the effectiveness of a novel biological treatment process for removing oxidants from concentrate waste streams, an electrodialysis reversal pilot plant was used to remove perchlorate, arsenic, and total dissolved solids from groundwater. The resulting concentrate stream was blended with scalped municipal wastewater and treated in a fixed-bed (FXB) bioreactor through a process called BIOBROx TM . The data showed that an empty bed contact time of 10 min and a 0.6 blend ratio of wastewater flow to total flow sustained perchlorate removal to below the methodreporting limit (4 µg/L) in the FXB bioreactor. Testing also showed that the system was robust with respect to process upsets and temperature variations. Ongoing full-scale testing is designed to optimize the process so that BIOBROx effluent can be used directly for reuse applications after disinfection.