BIOLOGICAL VALUE AND ESSENTIAL OIL COMPOSITION OF TWO Monarda SPECIES FLOWERS

Grzeszczuk, Monika; Wesołowska, Aneta; Stefaniak, Anna

doi:10.24326/asphc.2020.4.10

Cited by 18 publications

(27 citation statements)

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“…As Mazza and Marshall indicated, the chemical composition of M. fistulosa essential oils is dependent on genotype and geographic origin [64]. Indeed, our results were comparable to the composition of M. fistulosa essential oils obtained from the Szczecin region in Poland, which had carvacrol, p-cymene, α-terpinene, and γ-terpinene as the major constituents [62] and were distinct from the high thymol content (60.8%) in M. fistulosa essential oils reported by Lawrence [65].…”

Section: Discussionsupporting

confidence: 85%

“…The genus Monarda is represented by 20 native species, with M. fistulosa (wild bergamot) essential oils being used medicinally to treat cardiovascular defects, wounds, colds and flu, gastrointestinal disorders, insomnia, and infant convulsions [1]. Along with potent antimicrobial and antioxidant activity [16,62], Duke suggested that M. fistulosa also has anticarcinogenic properties [63]. In the present study, we defined the chemical profile of essential oils extracted from M. fistulosa flowers (MEO Fl ) and leaves (MEO Lv ).…”

Section: Discussionmentioning

confidence: 99%

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Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

et al. 2020

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Little is known about the pharmacological activity of Monarda fistulosa L. essential oils. To address this issue, we isolated essential oils from the flowers and leaves of M. fistulosa and analyzed their chemical composition. We also analyzed the pharmacological effects of M. fistulosa essential oils on transient receptor potential (TRP) channel activity, as these channels are known targets of various essential oil constituents. Flower (MEOFl) and leaf (MEOLv) essential oils were comprised mainly of monoterpenes (43.1% and 21.1%) and oxygenated monoterpenes (54.8% and 77.7%), respectively, with a high abundance of monoterpene hydrocarbons, including p-cymene, γ-terpinene, α-terpinene, and α-thujene. Major oxygenated monoterpenes of MEOFl and MEOLv included carvacrol and thymol. Both MEOFl and MEOLv stimulated a transient increase in intracellular free Ca2+ concentration ([Ca2+]i) in TRPA1 but not in TRPV1 or TRPV4-transfected cells, with MEOLv being much more effective than MEOFl. Furthermore, the pure monoterpenes carvacrol, thymol, and β-myrcene activated TRPA1 but not the TRPV1 or TRPV4 channels, suggesting that these compounds represented the TRPA1-activating components of M. fistulosa essential oils. The transient increase in [Ca2+]i induced by MEOFl/MEOLv, carvacrol, β-myrcene, and thymol in TRPA1-transfected cells was blocked by a selective TRPA1 antagonist, HC-030031. Although carvacrol and thymol have been reported previously to activate the TRPA1 channels, this is the first report to show that β-myrcene is also a TRPA1 channel agonist. Finally, molecular modeling studies showed a substantial similarity between the docking poses of carvacrol, thymol, and β-myrcene in the binding site of human TRPA1. Thus, our results provide a cellular and molecular basis to explain at least part of the therapeutic properties of these essential oils, laying the foundation for prospective pharmacological studies involving TRP ion channels.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

et al. 2020

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“…Additionally, methyl carvacrol is also found to constitute about 4.80% to 4.89% of the Eos (Markovska et al, 2020). However, the composition of active compounds depends on the genotype and the cultivation place (Grzeszczuk et al, 2020).…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

“…In order to obtain information regarding the antioxidant activities of thymol and carvacrol, several tests can be conducted. The first one is the DPPH test which will monitor the effectiveness of the compounds against free radicals (Grzeszczuk et al, 2020). According to the study by Yildiz et al (2020), thymol shows 25.0% of DPPH antiradical activity and carvacrol shows 18.3% activity at 1000 ppm concentration.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

A Review on Pharmacological Activity of Monarda fistulosa L.

Wahyudi¹,

Chung²,

Chelovna³

et al. 2022

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Monarda fistulosa is a plant often used in traditional medication with numerous benefits. This review paper aims to elaborate on the phytochemicals of Monarda fistulosa that contribute to its pharmacological activity. Numerous studies have found the bioactive compounds of Monarda fistulosa including carvacrol, thymol, thymoquinone, flavonoid, ????-pinene, caryophyllene oxide, limonene, and geraniol. Researchers have found several pharmacological activities in relation to these compounds including antimicrobial, antidiabetic, anticancer, anti-inflammatory, antioxidants, and immunomodulatory properties. Evidence shows that Monarda fistulosa has potential for applications in many areas. Nevertheless, further clinical studies still have to be conducted to assess the effects of this plant.

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“…Además, las flores son ricas en néctar y polen, y diferentes estudios han demostrado que el polen es rico en vitaminas y minerales (Grzeszczuk et al, 2011;Feás et al, 2012).…”

Section: Composición De Las Flores Comestiblesunclassified

Caracterización nutricional y aromática de flores comestibles de liliáceas

Núñez¹

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Caminante no hay camino, se hace camino al andar y mejor aún si en ese recorrido te acompañan seres que han marcado tu vida de una u otra forma. Quiero empezar agradeciendo a mi querida Loly la Doctora Mª Dolores Raigón, gracias por la dedicación y paciencia, quien desde el primer día que me acerque a solicitarle sea mi tutora de TFM, con una sonrisa me dijo claro que sí, y desde aquel día hasta hoy admiro y respeto la gran persona y profesional que es, gracias por su guía y consejos, porque siempre estuviste cuando te necesite, por todo el apoyo y dedicación brindada para culminar este trabajo, también quiero agradecerte por la confianza ofrecida todo este tiempo, eres la mejor.Gracias a Loles y todo el departamento de Química por toda la ayuda brindada en la parte experimental, siempre con la mejor voluntad de trabajar en bien de la investigación Gracias a la vida que me ha dado tanto como dice la canción de Mercedes Soza, me dio una familia que son el motor principal en mi vida y la motivación de todos los días para seguir adelante y seguir creciendo como padre, esposo y amigo, gracias Verito, Pedrito David y María Valentina por ser mi fuerza e inspiración, todo para y por ustedes.Como no agradecer a mis Padres, Telmo y Olguita, Suegros, Hermanos, Eleny, Adry y demás familiares que han sido parte de mi motivación para seguir creciendo cada día, gracias por bríndame ese apoyo incondicional para cumplir todos mis objetivos académicos y personales.A mi Ubita y Piedadcita por ser el pilar fundamental de mi vida, por también ser el motivo e inspiración para cumplir con todas mis metas, con su cariño me impulsan a seguir adelante y a nunca abandonar mis sueños.Gracias a mis amigos Maury, Paul, Sonyta y muchos más, que siempre me han prestado un gran apoyo moral y humano, necesarios en los momentos difíciles de este trabajo.Esta meta cumplida es por ustedes y para ustedes. RESUMENLas flores, además de su significado cultural, han sido consumidas desde la antigüedad en muchas culturas alrededor del mundo. Se utilizaban en diferentes preparaciones culinarias o en diversos platos como guarnición. En los últimos años se ha renovado el interés por el consumo de flores frescas debido a su valor nutricional y propiedades medicinales. Las flores aportan nuevos colores, sabores y texturas a los alimentos y sirven como fuente potencial de varios compuestos bioactivos como polifenoles, flavonoides y pigmentos, que ejercen una actividad antioxidante muy alta. Los recientes estudios han revelado que, al ser una rica fuente de antioxidantes, el consumo de estas flores es efectivo como agentes antiinflamatorios, antimicrobianos, hepatoprotectores, anticancerígenos y antidiabéticos. Por lo tanto, las flores se pueden utilizar como fuente de alimentos nuevos y prometedores para una amplia aplicación en la nutrición humana, representando un segmento importante para expandir el mercado de alimentos.Los factores socioculturales involucrados en el consumo de flores comestibles han permitido popularizar, expandir y fomentar el uso local d...

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BIOLOGICAL VALUE AND ESSENTIAL OIL COMPOSITION OF TWO Monarda SPECIES FLOWERS

Cited by 18 publications

References 0 publications

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels

A Review on Pharmacological Activity of Monarda fistulosa L.

Caracterización nutricional y aromática de flores comestibles de liliáceas

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