Biologically Active Macrocyclic Diterpenoids from Chinese Drug “Fáng Féng Cáo” I. Isolation and Structure¹

Abstract

Three novel macrocyclic diterpepoids, 4,7-oxycyAbstract: The total synthesis of ethyl 3-carboline-1-propionate has been described and its ability to bind toward benzodiazepine and GABA receptors has been studied. It has been suggested that j3-carboline-1-propionic acid is the true natural product, its ester derivatives are only artefacts of the isolation procedure.

Hypotensive activity of ovatodiolides isolated from a Chinese crude drug ‘Fáng Féng Cáo’

“…The ovatodiolides slightly inhibited ACE activity in vitro and showed Ca'+ antagonistic activity in single atrial cells. The CaZ+ antagonistic order of potency was 1 > > 2 > 3 , and correlate with the order of potency for the cell growth inhibitory activity (Arisawa et al, 1986b). These findings seemed to suggest a relationship between the inhibitory mechanism of cell growth and the Ca2+ antagonistic action.…”

Ovatodiolides: Scalable Protection‐Free Syntheses, Configuration Determination, and Biological Evaluation against Hepatic Cancer Stem Cells

“…X‐ray analysis of 2 , combined with a comparison of optical data, confirmed 2 as isoovatodiolide with the opposite configuration at C10 compared to ovatodiolide. Further transformation of the isolated ovatodiolide 1 with m ‐CPBA produced 4,5‐epoxyovatodiolide ( 3 ), another natural product, whose absolute configuration was confirmed via X‐ray analysis (Figure A). Direct reduction of the α‐methylene unit of 1 afforded a mixture of isomers ( 19 ) in a ratio of 2.3:1.…”

Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica

“…Br., is a cembrane-type diterpenoid, which can be synthesized chemically [3]. Anisomelic acid has also been previously isolated from A. malabarica [4] and A. indica and it has been shown to be cytotoxic to KB cells [5, 6]. A. malabarica has been shown to possess many other compounds viz., Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate, Anisomelol, etc.…”