Biologically improved nanofibrous scaffolds for cardiac tissue engineering

Bhaarathy, V.; Venugopal, Jayarama Reddy; Gandhimathi, Chinnasamy; Ponpandian, N.; Mangalaraj, D.; Ramakrishna, Seeram

doi:10.1016/j.msec.2014.08.018

Cited by 73 publications

(42 citation statements)

References 42 publications

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“…20). Recently, biocomposite nanofibrous scaffolds consisting of two or more polymeric blends were fabricated into uniform copolymers with interconnected pores to form flexible, cell-supporting substrates with desired biofunctional and biomechanical properties dependent on their applications [669]. The intricate and ingenious geometry is responsible for the overall performance of such tissue engineering templates [33,34].…”

Section: Future Directions and Outlookmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Future Directions and Outlookmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

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“…Bhaarathy et al have incorporated 2 different components in the initial polymer to improve different functionalities [123]. Their study uses PLCL, silk fibroin (SF) and Aloe Vera (AV) to create a scaffold via electrospinning so as to use it as an implantable material.…”

Section: Co-electrospinning With Biological Materialsmentioning

confidence: 99%

“…These plasma coated PCL fibers were tested in vivo in a rat model and had shown good mechanical integrity ( figure 9). Bhaarathy et al use air plasma treatment to improve the wettability of the surface of PLCL, SF and AV blend biocomposite nanofibrous scaffolds [123]. Plasma treated samples become more hydrophilic, allowing the attachment of cardiac cells as well as the desired proliferation and shape.…”

Section: Post Treatment By Plasma Modificationmentioning

confidence: 99%

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

et al. 2017

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Please cite this article as: Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y., Menasché, P., Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering, Acta Biomaterialia (2016), doi: http://dx.doi.org/ 10. 1016/j.actbio.2016.11.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells.The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications.Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic. Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo-like environment are reported.

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“…In vitro cell viability assay showed an improvement of fibroblast proliferation, and in vivo study demonstrated significant acceleration of wound closure and reepithelization. Bhaarathy et al [102] fabricated composite electrospun nanofibers using copolymer poly(l-lactic acid)- co -poly(ε-caprolactone) (PLACL), silk fibroin (SF), and aloe vera for cardiac tissue engineering. The results demonstrated that PLACL/SF/aloe vera nanofibers have more desirable properties compared to PLACL and PLACL/SF nanofibers.…”

Section: Aloe Vera Based Tissue Engineering Scaffoldsmentioning

confidence: 99%

Aloe Vera for Tissue Engineering Applications

Rahman

Carter

Bhattarai

2017

JFB

158

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Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

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Biologically improved nanofibrous scaffolds for cardiac tissue engineering

Cited by 73 publications

References 42 publications

Advancing biomaterials of human origin for tissue engineering

Advancing biomaterials of human origin for tissue engineering

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

Aloe Vera for Tissue Engineering Applications

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