Biologische Oxydation und Reduktion am Stickstoff aromatischer Amino- und Nitroderivate und ihre Folgen für den Organismus

Uehleke, H.

doi:10.1007/978-3-0348-7056-6_3

Cited by 9 publications

(5 citation statements)

References 233 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For melamine, 2,4,6-triamino-, 6-hydroxy-and 2,4-diamino-pyrimidines; protein precipitation was carried out by the addition of 3ml acetone and the aqueous layer was evaporated to dryness as in (2).…”

Section: Extractionmentioning

confidence: 99%

“…N-Oxygenation of aromatic heterocycles was established as a metabolic route by Chaykin and Bloch (1) since then nitrogen oxygenation has been reported to occur in many xenobiotics (2)(3)(4)(5). Other examples of tertiary aromatic amines susceptible to enzymic Noxygenation are nikethamide, quinoline, and acetylpyridine (6)(7)(8), studies in our laboratory have shown that this process occurs in a wide variety of 3-substituted (9,10) and 2-and 4-substituted pyridines (11) and that it is predominantly mediated by a phenobarbitone-inducible form of cytochrome P450 (12,13).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines

El-Ghomari

Gorrod

1987

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

Biological oxidation of 2,4-diamino-6-substituted pyrimidines have been studied using hepatic microsomes from various mammalian species. The nature of the enzyme(s) involved in the oxidation has been elucidated using various enzyme inhibitors and inducing agents. The 3-N-oxides were formed with 6-piperidino-, 6-diethylamino-, 6-methyl-, and 6-chloro-substituted 2,4-diaminopyrimidines: no evidence of 1-N-oxide formation was obtained. With the 6-hydroxy-, 6-amino-, and unsubstituted 2,4-diaminopyrimidines and melamine, no N-oxidative metabolite was detected. The differences in N-oxide formation was discussed in terms of the effect of substituents on tautomerism and electron distribution. The N-oxygenation was mediated via a cytochrome P450 dependent system.

show abstract

Section: Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines

El-Ghomari

Gorrod

1987

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

show abstract

“…Inhalativ oder dermal aufgenommene Aminoaromaten können über die Methämoglo-binbildung (Met-Hb) [2][3][4] klinisch auffällige Cyanosen induzieren. Sie werden in Abhängigkeit von ihrer Menge, der Verteilungsgeschwindigkeit im Organismus, dem Polymorphismus der beteiligten Enzyme und einem möglichen Synergismus mit weiteren Fremdstoffbelastungen über unterschiedliche Stoffwechselwege wieder ausgeschieden [5][6][7][8].…”

Section: Metabolismus Und Wirkungsweiseunclassified

Aromatische Amine (Anilin, o‐, m‐, p‐Toluidin, 4‐Chlor‐o‐toluidin, 2,4‐ und 2,6‐Toluylendiamin, 4‐Aminodiphenyl, 4,4′‐Diaminodiphenylmethan) [Biomonitoring Methods in German language, 1994]

Lewalter¹,

Biedermann²

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 11. Lieferung, Ausgabe 1994 Der Artikel enthält folgende Kapitel: Grundlage des Verfahrens Geräte, Chemikalien und Lösungen Geräte Chemikalien Lösungen Vergleichsstandards Probenahme und Probenaufbereitung Probenahme Probenvorbehandlung Probenaufbereitung Derivatisierung Gaschromatographische Arbeitsbedingungen Analytische Bestimmung Kalibrierung Berechnung des Analysenergebnisses Beurteilung des Verfahrens Präzision Richtigkeit Nachweisgrenze Störeinflüsse Diskussion der Methode

show abstract

“…Certain nitrogen-containing drugs may produce methemoglobinemia. 31 When aniline was incubated with hemoglobin-contaminated human fetal liver preparations, methemoglobin was formed, as measured spectrophotometrically.28 Various amines ( and ami des ) are known to have carcinogenic" 22, 26 and other adverse effects 31 that are ascribed to their N-oxygenated metabolites. Moreover, Arrhenius 1 has shown the hepatic N-oxidation of DMA to be correlated with the susceptibility of the animal to the carcinogenic action of amines.…”

Section: Clinical Pharmacology and Therapeuticsmentioning

confidence: 99%

N‐oxidation of a tertiary amine (N,N‐dimethylaniline) by human fetal liver microsomes

Rane

1974

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

Many nitrogen-containing drugs and foreign compounds are N-oxygenated in vertebrates,20 including man. 4 . 7, 11, 12, 18,23,36 For certain drugs, N-oxygenation is a quantitatively important route of metabolism, at least in vitro. 3 , 6 Drug oxidations, including C-hydroxylations and N-dealkylations, are known to be catalyzed by liver microsomal enzymes and to be dependent on oxygen and reduced nicotinamide adenine dinucleotide phosphate (NADPH) for activity, and this is also true for N-oxygenation reactions. 2 , 37 However, while the classical drug-oxidative reactions and the N-oxygenation of primary amines are dependent on the NADPH-

show abstract

Biologische Oxydation und Reduktion am Stickstoff aromatischer Amino- und Nitroderivate und ihre Folgen für den Organismus

Cited by 9 publications

References 233 publications

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines

Aromatische Amine (Anilin, o‐, m‐, p‐Toluidin, 4‐Chlor‐o‐toluidin, 2,4‐ und 2,6‐Toluylendiamin, 4‐Aminodiphenyl, 4,4′‐Diaminodiphenylmethan) [Biomonitoring Methods in German language, 1994]

N‐oxidation of a tertiary amine (N,N‐dimethylaniline) by human fetal liver microsomes

Contact Info

Product

Resources

About