Biology of Allograft Incorporation

Eagan, Michael; McAllister, David R.

doi:10.1016/j.csm.2008.10.009

Cited by 47 publications

(47 citation statements)

References 57 publications

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“…Osteoclasts infiltrated and resorbed the CaP/PUR composites near the bone‐implant interface, as confirmed by TRAP staining (Figure 9). Although there is limited evidence of remodeling at the early time point investigated (4 weeks), infiltration of osteoclasts near the implant‐bone interface suggests that at later time points the CaP/PUR composites may remodel via slow reverse creeping substitution,41–43 as reported previously for allograft/PUR composites. However, the rates of cellular infiltration and resorption were substantially less than those observed for allograft/PUR composites at similar filler loadings 19.…”

Section: Discussionmentioning

confidence: 67%

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

et al. 2011

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Calcium phosphate (CaP)/polymer composites have been studied as an alternative graft material for the treatment of bone defects. In this study, lysine-triisocyanate-based polyurethane (PUR) composites were synthesized from both hydroxyapatite (HA) and β-tricalcium phosphate (TCP) to reduce the brittleness of CaP and increase the bioactivity of the polymer. The mechanical properties and in vitro cellular response were investigated for both HA/PUR and TCP/PUR composites. The composites were implanted in femoral defects in rats, and in vivo bioactivity was evaluated by X-rays, micro-computed tomography (μCT), and histological sections. In biomechanical testing, PUR improved the mechanical properties of the CaP, thus rendering it potentially suitable for weight-bearing applications. In vitro cell culture studies showed that CaP/PUR composites are biocompatible, with β-TCP enhancing the cell viability and proliferation relative to HA. CaP/PUR composites also supported the differentiation of osteoblastic cells on the materials. When implanted in rat femoral defects, the CaP/PUR composites were biocompatible and osteoconductive with no adverse inflammatory response, as evidenced by X-rays, μCT images, and histological sections. Additionally, a histological examination showed evidence of cellular infiltration and appositional remodeling. These results suggest that CaP/PUR composites could be potentially useful biomaterials for weight-bearing orthopaedic implants.

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Section: Discussionmentioning

confidence: 67%

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

et al. 2011

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“…HV composites were formulated with high loading of allograft particles to provide a pathway for cells to infiltrate the composites through creeping substitution. 17,21 Pore size and porosity Thin sections of cured specimens were sputter-coated for 45 s using a Cressington Q108 sputter coater, which deposited gold at a 30 mA current, and imaged using scanning electron microscopy (Hitachi S-4200 SEM). Images (n 5 3 per formulation) were analyzed for pore size using ImageJ 1.47 image analysis software.…”

Section: Synthesis Of Polyester Triolmentioning

confidence: 99%

Effects of particle size and porosity on in vivo remodeling of settable allograft bone/polymer composites

et al. 2015

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Established clinical approaches to treat bone voids include the implantation of autograft or allograft bone, ceramics, and other bone void fillers (BVFs). Composites prepared from lysine-derived polyurethanes and allograft bone can be injected as a reactive liquid and set to yield BVFs with mechanical strength comparable to trabecular bone. In this study, we investigated the effects of porosity, allograft particle size, and matrix mineralization on remodeling of injectable and settable allograft/polymer composites in a rabbit femoral condyle plug defect model. Both low viscosity (LV) and high viscosity (HV) grafts incorporating small (<105 μm) particles only partially healed at 12 weeks, and the addition of 10% demineralized bone matrix did not enhance healing. In contrast, composite grafts with large (105 – 500 μm) allograft particles healed at 12 weeks post-implantation, as evidenced by radial μCT and histomorphometric analysis. This study highlights particle size and surface connectivity as influential parameters regulating the remodeling of composite bone scaffolds.

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“…However, the use of an autologous bone graft from the iliac crest prevents frequent comorbidities related to blood loss at the donor site, increased operative time, and risk of infection [6]. However, there exist small risks of disease transmission, immunologic rejection, and biologic incorporation with these grafts [10,11]. However, there exist small risks of disease transmission, immunologic rejection, and biologic incorporation with these grafts [10,11].…”

Section: Introductionmentioning

confidence: 99%

Femoral segment graft is a suitable alternative to stabilize pelvic osteotomies in developmental dysplasia of the hip

Ertürk

Altay²,

Işkan³

2012

Journal of Pediatric Orthopaedics B

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The aim of this study was to compare bone healing in pelvic osteotomy patients with osteotomy gaps filled with a femoral segment resected (FSR) graft with bone healing in patients with an iliac tricortical autograft (ITA) in treatment of developmental dysplasia of the hip. Sixty-three hips were treated using FSR grafts. Sixty-one hips were treated using ITA. The mean operation time and blood loss were significantly reduced in the FSR graft group, but graft union time was extended in the FSR graft group compared with that in the ITA group. The FSR graft was found to be safe and effective in treatment of developmental dysplasia of the hip and serves as an advantageous alternative to ITA.

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Biology of Allograft Incorporation

Cited by 47 publications

References 57 publications

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

Effects of particle size and porosity on in vivo remodeling of settable allograft bone/polymer composites

Femoral segment graft is a suitable alternative to stabilize pelvic osteotomies in developmental dysplasia of the hip

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