Biology of diabetic neuropathy

Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle

“…Ctrl, control; IP, immunoprecipitate morbidities has been only partially investigated from a mechanistic perspective. However, the role of the dynamic epigenome in contributing the major traits of type 2 diabetes is receiving progressively greater attention because this information may expand present understanding of the pathogenesis of type 2 diabetes [38][39][40].…”

Диабетическая Кардиальная Автономная Нейропатия: Каковы Перспективы В Лечении?

“…Получение необходимого количества энергии в сочетании с физиологическим рационом питания формирует диетические принци-пы. Традиционная средиземноморская диета (Греция и Южная Италия) связана с долголетием и/или низкой смертностью вследствие осложнений сердечно-сосу-дистых заболеваний (ССЗ), низкой частотой широкого спектра хронических заболеваний, включая ревмато-идный артрит, болезнь Паркинсона и другие заболе-вания, а также снижает заболеваемость СДТ2 [21][22][23].…”

Pharmacokinetics of the transdermal delivery of benfotiamine

“…In particular, AGEs are found in the peripheral nerves, kidney and the retina of the diabetic patients [1,[3][4][5]. These glycated proteins are impaired in & Zhen Zhu pzhu@biochemics.com function and structural integrity, which in turn negatively affects their functioning in the cell and tissue [6,7].…”

“…Although there are several different clinical symptoms experienced by patients suffering from diabetic peripheral neuropathy, one of the obvious clinical endpoints to consider for the development of a therapeutic for this diabetic complication is the treatment of pain associated with the neuronal dysfunction [1][2][3]. To this end, there have been several therapies established primarily using oral and some topically applied pain relievers ranging from serotonin reuptake inhibitors and morphine analogs to capsaicin [1].…”