Biology of Eye Pigmentation in Insects

Summers, Kim M.; Howells, A. J.; Pyliotis, N. A.

doi:10.1016/s0065-2806(08)60153-8

Cited by 111 publications

(88 citation statements)

References 108 publications

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“…In Drosophila, W is essential to both pigment pathways (Sullivan and Sullivan 1975;Sullivan et al 1979;Summers et al 1982), so it was not surprising to see that all individuals injected with Tcw dsRNA as larvae lacked eye pigmentation as pupae and adults ( Figure 2B). Moreover, our results for Tcst were also similar to that previously reported (Broehan et al 2013).…”

Section: Rna Interferencementioning

confidence: 99%

“…Among insects, ommochromes function as an important source of visible eye pigments (Linzen 1974). Species as diverse as mosquitoes, moths, bugs, and bees use only ommochromes for eye coloration (Dustmann 1968;Beard et al 1995;Quan et al 2002;Moraes et al 2005;Sethuraman and O'Brochta 2005), while in other species, like the grasshopper, Schistocerca gregaria (Dong and Friedrich 2005), or the fruit fly, Drosophila melanogaster (Summers et al 1982), ommochromes, together with the guanine-derived pteridines, create wild-type eye color.…”

mentioning

confidence: 99%

“…In Drosophila, eye coloration has attracted a great deal of study (Linzen 1974;Summers et al 1982), which has revealed that proper allocation of pigments depends on three half-type ATP-binding cassette (ABC) transmembrane transporters, which import pigment precursors into the appropriate cells for final processing (Mount 1987;Dreesen et al 1988;Tearle et al 1989;Mackenzie et al 1999). The transport protein, White (W), works with its paralog, Scarlet (St), to import precursors of ommochrome pigments (Sullivan and Sullivan 1975;Tearle et al 1989).…”

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confidence: 99%

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The ABCs of Eye Color inTribolium castaneum: Orthologs of theDrosophila white,scarlet, andbrownGenes

et al. 2015

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In Drosophila melanogaster, each of the three paralogous ABC transporters, White, Scarlet and Brown, is required for normal pigmentation of the compound eye. We have cloned the three orthologous genes from the beetle Tribolium castaneum. Conceptual translations of Tribolium white (Tcw), scarlet (Tcst), and brown (Tcbw) are 51, 48, and 32% identical to their respective Drosophila counterparts. We have identified loss-of-eye-pigment strains that bear mutations in Tcw and Tcst: the Tcw gene in the ivory (i) strain carries a single-base transversion, which leads to an E / D amino-acid substitution in the highly conserved Walker B motif, while the Tcst gene in the pearl (p) strain has a deletion resulting in incorporation of a premature stop codon. In light of these findings, the mutant strains i and p are herein renamed white ivory (w i ) and scarlet pearl (st p ), respectively. In addition, RNA inhibition of Tcw and Tcst recapitulates the mutant phenotypes, confirming the roles of these genes in normal eye pigmentation, while RNA interference of Tcbw provides further evidence that it has no role in eye pigmentation in Tribolium. We also consider the evolutionary implications of our findings.

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Section: Rna Interferencementioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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The ABCs of Eye Color inTribolium castaneum: Orthologs of theDrosophila white,scarlet, andbrownGenes

et al. 2015

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“…In Drosophila, drosopterins predominantly populate the secondary pigment cells (Summers et al, 1982;Stark and Sapp, 1988;Schraermeyer and Dohms, 1993). The pigments are photostable, but their absorbance spectrum distinctly depends on the redox state (Langer, 1975)• The general spectral characteristic is a drastic drop of the absorbanee in the red, above ca.…”

Section: Screening Pigmentsmentioning

confidence: 99%

Insect retinal pigments: Spectral characteristics and physiological functions

Stavenga

1995

Progress in Retinal and Eye Research

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“…We observed that, rather than a chimeric protein, the aberrant mRNA (LpinK-w) expressed in the KG00562 fly line encodes an aminoterminal deleted white protein containing the ABC domain (ATP Binding Cassette; Figure 2). The ABC domain is required for the white function in transporting molecules across membranes, such as the pigment precursors tryptophan and guanine (22)(23)(24), and the cGMP in Malpighian tubules (25). Lack of the white function impairs pigment production in the light-screening cells of the compound eye resulting in flies with white eyes, which is the most prominent phenotype of w mutants.…”

Section: Discussionmentioning

confidence: 99%