Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins

Huppertz, Berthold

doi:10.1016/j.bbadis.2018.11.024

Cited by 29 publications

(15 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, insights into the pathophysiology and diagnosis of these syndromes are still missing, which often leads to premature births with all its consequences. In addition, also affected women may have long-term health problems such as risk disposition for cardiovascular diseases [ 40 , 41 , 42 , 43 ]. Hence, finding specific diagnostic and curative treatments for the mother and fetus is a demanding task, requiring systemic studies of the placenta and the feto–maternal interface using innovative study designs.…”

Section: Discussionmentioning

confidence: 99%

Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation

Kupper

Pritz

Siwetz

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

During pregnancy, freely floating placental villi are adapted to fluid shear stress due to placental perfusion with maternal plasma and blood. In vitro culture of placental villous explants is widely performed under static conditions, hoping the conditions may represent the in utero environment. However, static placental villous explant culture dramatically differs from the in vivo situation. Thus, we established a flow culture system for placental villous explants and compared commonly used static cultured tissue to flow cultured tissue using transmission and scanning electron microscopy, immunohistochemistry, and lactate dehydrogenase (LDH) and human chorionic gonadotropin (hCG) measurements. The data revealed a better structural and biochemical integrity of flow cultured tissue compared to static cultured tissue. Thus, this new flow system can be used to simulate the blood flow from the mother to the placenta and back in the most native-like in vitro system so far and thus can enable novel study designs.

show abstract

Section: Discussionmentioning

confidence: 99%

Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation

Kupper

Pritz

Siwetz

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The usefulness of Lgals13 as a biomarker for PE has been questioned as late second-trimester Lgals13 alone does not increase the ability to predict PE when compared to second-trimester Doppler pulsatility index and other potential biochemical markers (168), highlighting the need to consider the interactions between different signaling pathways in disease pathogenesis when in search for sensitive, reliable biomarkers. In this regard, recent studies suggest that the kinetics of Lgals13 expression in PE would result from the concerted actions of this protein and antiangiogenic factors as sFlt-1 on the maternal vascular system, with a dual role for Lgals13: first in low levels acting as a priming insult promoting endothelial activation and angiogenic imbalance, and increasing later in the third trimester as a natural rescue response promoting maternal vasodilation to lower blood pressure (169). In the context of gestational diabetes mellitus (GDM), increased Lgals13 serum levels during the early second trimester and lower expression in trophoblast cells of the term placenta have been reported (170, 171).…”

Section: Galectin 13 (Lgals13)mentioning

confidence: 99%

Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

et al. 2019

View full text Add to dashboard Cite

Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

show abstract

“…As predictors of preeclampsia, these factors work better for early preeclampsia than late preeclampsia, and, generally speaking, as pregnancy nears term, the distinction between normal and abnormal based on angiogenic factors becomes blurred. 63 Moreover, the angiogenic factors are systemically expressed in the human body and have been used for the prediction and diagnosis of many other diseases such as chronic renal disease, several malignancies, sepsis, subarachnoid hemorrhage, and pancreatitis. This shows that the imbalance between pro-and antiangiogenic factors is not specific to preeclampsia.…”

Section: Toward a New Frameworkmentioning

confidence: 99%

Preeclampsia: The Need for a Biological Definition and Diagnosis

2020

View full text Add to dashboard Cite

The centuries-old approach to the prevention of eclampsia and its associated maternal morbidity and mortality is based on the recognition of the presence of premonitory signs and symptoms such as hypertension and proteinuria. The spectrum of preceding signs and symptoms came to be known as preeclampsia, which is debatably considered to be an early stage on a clinical continuum possibly leading to eclampsia. The premonitory signs and symptoms were then construed as diagnostic criteria for the poorly understood syndrome of preeclampsia, and this led to a perpetual debate that remains subject to wide disagreement and periodic updates. In this commentary, we will draw attention to the fact that the criteria for preeclampsia should be viewed from the prism of a screening test rather than as diagnostic of a condition in itself. Focusing research on developing better diagnostic and screening methods for what is clinically important, namely maternal and perinatal morbidity and mortality from hypertensive disorders of pregnancy, a long overdue upgrade from what was possible centuries ago, will ultimately lead to better management approaches to what really matters.

show abstract

Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins

Cited by 29 publications

References 80 publications

Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation

Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation

Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

Preeclampsia: The Need for a Biological Definition and Diagnosis

Contact Info

Product

Resources

About