Biology of the Aging Process and Its Clinical Consequences

Macías-Núñez, Juan-Florencio; Casado, José-Manuel Ribera; Rey, Mónica de la Fuente del; Quiroga, G. Barja de; Tresguerres, Jesús A.F.; Ariznavarreta, C.; López‐Novoa, José M.

doi:10.1007/978-0-387-72659-5_4

Cited by 5 publications

(3 citation statements)

References 85 publications

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“…It is worth emphasising that ageing is an intrinsic, deleterious, and cumulative process that with time reduces an organism's ability to withstand external stressors (such as infection and starvation) and increases its mortality risk [9] .…”

Section: Changes In Physiology During Ageingmentioning

confidence: 99%

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu

Valencak

2017

Gerontology

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The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity.

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Section: Changes In Physiology During Ageingmentioning

confidence: 99%

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu

Valencak

2017

Gerontology

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“…The basic metabolic rate decreases by 4% after the age of 50 due to a multitude of hormonal and immune factors, such as decreasing levels of testosterone, glucocorticoids, cytokines, and growth hormone, thus disrupting the normal balance between muscle breakdown and synthesis. Also, the lack of important minerals, such as calcium, creates a vulnerability to bone fractures, especially in women [2].…”

Section: Introductionmentioning

confidence: 99%

Exploring Social Support, Pain Self-Efficacy and Health Beliefs in Older Adults with Musculoskeletal Disorders

Anyfantopoulou,

Theofilou

2023

Series Clin Med Case Rep Rev

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Background: During the last decades, many studies have explored social support, pain self-efficacy, and health beliefs in older adults with musculoskeletal disorders. Aim: The purpose of the research is to investigate the beliefs of elderly people with musculoskeletal disorders regarding social support, self-efficacy in pain, and health locus of control. Methods: The research was carried out based on 3 questionnaires. The first questionnaire involved the Multidimensional Scale of Perceived Social Support, the second involved the Pain Self Efficacy Questionnaire, and the third included the Multidimensional Health Locus of Control (MHLC) scale. The research was conducted from April–June 2023 among 106 elderly people, of which 32 (30.2%) were men and 74 (69.8%) were women, members of long-term care services and others who visited the Open Care Center of Patras. Results: The mean age of the participants was 76.1 years and the majority were females, primary school graduates, and retired. Furthermore, most of them had moderate/mild manual labor, average financial status, and received medication for musculoskeletal problems. The results showed that there is a statistically significant positive correlation between pain self-efficacy and the support from the significant others (r = .370, p < .01), family support (r = .517, p < .01), overall social support (r = .435, p < .01), and financial status (r = .353, p < .01). Conclusion: The research showed that social support is positively related to pain self-efficacy in the elderly with musculoskeletal diseases.

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“…This can mainly be attributable to multiple comorbidities that elderly patients usually suffer from as well as the complexity of their medication regimens. Further, the declining cognitive abilities, dexterity problems, poor physician-patient communication, and high risk of adverse drug events are additional factors that can lead to non-adherence and are common among elderly patients (Macías-Núñez et al, 2008). Thus, the elderly patients are at higher risk of adverse drug events, medication mismanagement, and poor health outcomes.…”

Section: Medication Adherencementioning

confidence: 99%

The Value of Online Medication Rating Systems to Older Adults and Their Association with Self-Reported Outcomes

AlRuthia¹

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The Internet is a powerful and very popular vehicle for distributing judgment-free health information to patients. Multiple studies have examined the role of online health information as well as physician-rating websites in health care. Studies have examined the value of online drug information for patients and the value of the online drug information for patients. However, no study has examined the usefulness or value of online medication rating websites in facilitating physician-patient communication or participant-reported outcomes. In this study, the value of online medication rating websites to older adults in facilitating communication with their physicians using a newly developed tool was assessed. Additionally, the participant-reported outcomes of quality of life, satisfaction with physician communication, beliefs about medications, and medication adherence plus the relationship between the older adults' actual ratings of their antihypertensive medications and their self-reported outcomes were examined. Older adults with poor quality of life were more likely to view the online medication rating websites more favorably than participants who enjoy good quality of life. Participants who liked to share health decisions with their physicians were also more likely to have favorable views of the online websites. In addition, older adults with hypertension, who highly rated their antihypertensive medication regimens, were more likely to have good physical quality of life, high satisfaction with physician communication, positive beliefs about medications, and high medication adherence. Older adults with poor quality of life were more likely to be unsatisfied with their antihypertensive medications, have multiple comorbidities, limited health literacy, low satisfaction with their communication with their physicians, take multiple medications, and were more likely to view online medication rating websites favorably compared to their counterparts with good quality of life. Online medication rating websites may play an important role in enhancing physician-patient communication particularly among this segment of the patient population. vii 3.5.6 Older Adults' Evaluation of Their Antihypertensive Medication Regimens .

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Biology of the Aging Process and Its Clinical Consequences

Cited by 5 publications

References 85 publications

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Exploring Social Support, Pain Self-Efficacy and Health Beliefs in Older Adults with Musculoskeletal Disorders

The Value of Online Medication Rating Systems to Older Adults and Their Association with Self-Reported Outcomes

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