2017
DOI: 10.3390/v9110327
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Biology of the BKPyV: An Update

Abstract: The BK virus (BKPyV) is a member of the Polyomaviridae family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium. However, reactivation of BKPyV in immunocompromised individuals may cause serious complications. In particular, with the implementation of more potent immunosuppressive drugs in the last decade, BKPyV has become an emerging pathogen in kidney and bone marrow … Show more

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Cited by 78 publications
(69 citation statements)
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“…Mutations in the early region can lead to the expression of a truncated form of the large tumour antigen protein. Rearrangements in the non-coding control region and point mutations in VP1 have been described in two important human PyVs: JCPyV and BKPyV (Helle et al 2017). In the case of JCPyV, mutations of these loci lead to the development of progressive multifocal leukoencephalopathy.…”
Section: Polyomavirusesmentioning
confidence: 99%
“…Mutations in the early region can lead to the expression of a truncated form of the large tumour antigen protein. Rearrangements in the non-coding control region and point mutations in VP1 have been described in two important human PyVs: JCPyV and BKPyV (Helle et al 2017). In the case of JCPyV, mutations of these loci lead to the development of progressive multifocal leukoencephalopathy.…”
Section: Polyomavirusesmentioning
confidence: 99%
“…A better understanding of the BKPyV life cycle could permit identification of new therapeutic targets to inhibit virus replication (4). In particular, only a few studies have been dedicated to understanding the mechanisms of virion assembly and release.…”
mentioning
confidence: 99%
“…An alternative entry pathway involving a heparin-like attachment receptor and a nonsialylated coreceptor has also been described [ 52 ]. Concerning BKPyV, naked particles interact with the sialic-acid moiety of different types of b-series gangliosides such as GD3, GD2, GD1b, and GT1b, but an N-linked glycoprotein containing (2,3)-linked sialic acid could also act as a host receptor [ 53 , 54 , 55 ]. Both polyomaviruses are then internalized by endocytosis, followed by viral trafficking to the endoplasmic reticulum (ER) and nucleus for replication.…”
Section: Entry Of Ev-associated Virionsmentioning
confidence: 99%