Biology of the human histocompatibility leukocyte antigen (HLA) system and a hypothesis regarding the generation of autoimmune diseases.

Strominger, Jack L.

doi:10.1172/jci112451

Cited by 57 publications

(4 citation statements)

References 45 publications

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“…The susceptibility to arthritis is major histocompatibility complex-linked in humans and in rodents (2)(3)(4)(5). In humans the disease is initiated by exposure to various (as yet unidentified) antigenic stimuli.…”

mentioning

confidence: 99%

Regression of adjuvant-induced arthritis in rats following bone marrow transplantation.

Bekkum

Bohre

Houben

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

114

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Total body irradiation followed by bone marrow transplantation was found to be an effective treatment for adjuvant arthritis induced in rats. This treatment is most effective when applied shortly after the clinical manifestation of arthritis--i.e., 4-7 weeks after administration of Mycobacterium tuberculosis. Transplantation of bone marrow at a later stage results in a limited recovery, in that the inflammatory reaction regresses but the newly formed excessive bone is not eliminated. Local irradiation of the affected joints had no effect on the disease. It could also be excluded that the recovery of arthritis following marrow transplantation is due to lack of available antigen. Transplantation of syngeneic bone marrow is as effective as that of allogeneic bone marrow from a rat strain that is not susceptible to induction of adjuvant arthritis. The beneficial effect of this treatment cannot be ascribed to the immunosuppressive effect of total body irradiation, since treatment with the highly immunosuppressive drug Cyclosporin A resulted in a regression of the joint swelling but relapse occurred shortly after discontinuation of the treatment.

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mentioning

confidence: 99%

Regression of adjuvant-induced arthritis in rats following bone marrow transplantation.

Bekkum

Bohre

Houben

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

114

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“…The molecular diversity afforded by D locus gene products provides an explana- tion of disease susceptibility. These data also reveal that individuals who, by conventional serologic and cytotoxicity testing appear ho mogeneous, may differ considerably at the molecular level and thus in the expression of the variable regions of class II molecules at the cell surface [32]. Clearly such approaches (by gene probes or amino acid sequencing) will ultimately permit identification of indi viduals for a particular disease specificity, or reactivity towards a specific antigen; obser vations on this front have already been made with regard to gluten sensitivity [33].…”

Section: Immunologic Considerationsmentioning

confidence: 73%

Coeliac Sprue: A Centennial Overview 1888-1988

Marsh

Loft²

1988

Dig Dis

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“…IDDM is strongly associated with HLA antigen DR4 in Koreans, with DR4 and DRw9 in Japanese, with DR3 and DRw9 in Chinese and with DR3 and DR4 in Caucasoids, while DR2 is unequivocally decreased in IDDM of all populations. However, these different population associations may suggest that it is not the DR antigens themselves, but rather some linked locus that encodes the primary disease-promoting genes 6 ) . Furthermore, molecular genetic studies have shown particular DQ β restriction fragments to be more strongly associated with both susceptibility to, and protection against IDDM 7 – 17 )…”

Section: Introductionmentioning

confidence: 99%

RFLP Analysis of HLA-DRβ and -DQβ Genes in the Korean Patients with Insulin-Dependent Diabetes Mellitus

Lee¹,

Rhee²,

Koh³

et al. 1989

Korean J Intern Med

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Human genomic DNA samples from 19 Korean patients and 31 controls of known serological DR antigen specificity were studied for insulin-dependent diabetes mellitus (IDDM)-associated variation in HLA-DRβ and - DQβ restriction fragment length polymorphisms (RFLPs). Genotyping allowed for accurate assignment of HLA-DR types. For HLA-DRw6, a 12kb/DRβ/Taq I fragment was decreased in Korean IDDM (p<0.05). However, we could not find an increased frequency of a 12kb/DQβ/Bam HI fragment or decreased frequency of a 3.7kb/DQβ/Bam HI fragment in Korean IDDM. These results suggest a possible protective role of the HLA-DRw6 specificity in IDDM, irrespective of ethnic background, the absence of a specific DQβ RFLP pattern associated with IDDM in Koreans, and the difference of the Korean population in the genetic of IDDM, compared to the Caucasoid population.

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Biology of the human histocompatibility leukocyte antigen (HLA) system and a hypothesis regarding the generation of autoimmune diseases.

Cited by 57 publications

References 45 publications

Regression of adjuvant-induced arthritis in rats following bone marrow transplantation.

Regression of adjuvant-induced arthritis in rats following bone marrow transplantation.

Coeliac Sprue: A Centennial Overview 1888-1988

RFLP Analysis of HLA-DRβ and -DQβ Genes in the Korean Patients with Insulin-Dependent Diabetes Mellitus

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