Biomanufacturing for tissue engineering: Present and future trends

Bartolo, Paulo Jorge Da Silva; Chua, Chee Kai; Almeida, Henrique A.; Chou, Siaw Meng; Lim, Audrey

doi:10.1080/17452750903476288

Cited by 140 publications

(76 citation statements)

References 57 publications

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“…This technology is successfully applied in many biomedical applications including skin, heart and retina bioprinting, etc. [22] The 3D bioprinting technology can efficiently and precisely produce the retina equi valent that a biomimetic platform can be built (Figure 1) [23][24][25] . This proposed platform will be extremely useful for eyerelated diseases' risk assessments and drug testing.…”

Section: Discussionmentioning

confidence: 99%

Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research

Shi¹,

Edgar²,

Yeong³

et al. 2024

IJB

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Abstract:In this article, a hybrid retina construct was created via three-dimensional (3D) bioprinting technology. The construct was composed of a PCL ultrathin membrane, ARPE-19 cell monolayer and Y79 cell-laden alginate/pluronic bioink. 3D bioprinting technology was applied herein to deliver the ARPE-19 cells and Y79 cell-laden bioink to ensure homogeneous ARPE-19 cell seeding; subsequently, two distinctive Y79 cell-seeding patterns were bioprinted on top of the ARPE-19 cell monolayer. The bioprinted ARPE-19 cells were evaluated by prestoblue assay, F-actin, and hematoxylin/eosin (HE) staining, and then the cells were observed under laser scanning and invert microscopy for 14 days. The Y79 cells in alginate/pluronic bioink after bioprinting had been closely monitored for 7 days. Live/dead assay and scanning electrical microscopy (SEM) were employed to investigate Y79 cell viability and morphology. Both the ARPE-19 and Y79 cells were in excellent condition, and the successfully bioprinted retina model could be utilized in drug delivery, disease mechanism and treatment method discoveries.

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Section: Discussionmentioning

confidence: 99%

Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research

Shi¹,

Edgar²,

Yeong³

et al. 2024

IJB

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“…Выходом из положения может стать примене-ние индивидуализированных сложнопрофильных имплантатов, спроектированных и изготовленных с использованием современных технологий: быс-трого прототипирования [11][12][13][14] и 3D-стереолито-гра фии [15].…”

Section: Introductionunclassified

Experience of Using Individual Titan Implants in Nasal Reconstruction Surgery

Epishev

Petrova

Аладин

et al. 2016

RJTAO

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1 ФГБОУ ВПО «Южно-Уральский государственный университет» (Национальный исследовательский университет), Челябинск, Российская Федерация 2 ГБУЗ «Челябинский областной клинический онкологический диспансер», Челябинск, Российская Федерация Цель. Клиническое применение имплантатов с индивидуальными топографо-анатомическими данны-ми пациента. Материалы и методы. Описываются 2 клинических случая восстановления структуры носа, нарушенной в ходе операций по поводу рака области лица. При помощи технологии селективного лазерного сплавления по данным КТ/МРТ было изготовлено 2 сложных, деформированных в трехмер-ном пространстве индивидуальных имплантата из порошков сплава Ti 70 V 30 . Клиническое применение проходило в отделении хирургии головы и шеи Челябинского окружного онкологического диспансера. Результаты. В первом клиническом случае был достигнут отличный функциональный результат -боль-шая и широкая полость носа, каркас носа и свободное носовое дыхание. Через 30 дней эндоскопический видеоанализ (через носовые отверстия) показал 65% покрытие поверхности имплантата слизистой обо-лочкой. Во втором случае проведена комбинированная операция по удалению мягких тканей, атипичная резекция верхней челюсти слева, левой щеки, гайморотомия слева и реконструкция левой половины носа и левой щеки с помощью имплантата и лучевого лоскута. Заключение. Клиническое применение по-казало плюсы и минусы технологии. К минусам относится относительно высокая стоимость и высокие профессиональные требования к врачу, программисту, инженерам. К плюсам -свобода моделирования и задание параметров будущего имплантата до операции и точное соответствие размеров и формы имплан-тата топографо-анатомическим данным конкретного пациента. Aim. Clinical use of implants based on patient's individual topographic anatomical features. Materials and methods. The paper describes two case reports involving the correction of nasal anatomical structure affected during the surgery for facial cancer. Using selective laser sintering technology we manufactured 2 intricate 3D-deformed individual implants from Ti 70 V 30 alloy powders. Implant design was based on CAT/MRT data. Clinical use was conducted on the premises of the department of head and neck surgery in Chelyabinsk Regional Oncological Dispensary. Results. In the fi rst case we obtained an impressive functional result -huge and wide nasal cavity, nose skeleton, and easy nasal breathing. In 30 days we performed endoscopic video-analysis (via nasal passages) which showed that 65% of implant surface was covered with mucosa. In the second case, the designed

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“…Tissue Engineering is an emerging field that complies different areas of science focusing essentially on the use of cells, biomaterials, computational methods and fabrication processes ( Figure 1) merging principles of areas such as biology, engineering and medicine in order to create biological tissues that are functionally defective or damaged (Eshraghi and Das, 2010;Bártolo et al, 2009a;2009b;Gibson, 2005;Tan et al, 2005;Vozzi et al, 2003;Risbud, 2001). Skalak and Fox (1988), defined Tissue Engineering as the "application of the principles and methods of engineering and life sciences toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain, or improve tissue and organ functions" (Bártolo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

2014

Biodental Engineering III

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AgradecimentosAo Professor Doutor Henrique Almeida, meu orientador e grande amigo, a quem agradeço a sua generosa paciência, exigência e ambição. Os contínuos estímulos para prosseguir este trabalho e o contínuo apoio moral e cientifico foram sempre determinantes para que continuasse a desenvolver esta dissertação. Agradeço profundamente a amizade com que me prendou durante todos estes anos do meu percurso académico e profissional, que revelam uma pessoa dedicada, competente e honesta.Ao Professor Doutor Paulo Bártolo, meu co-orientador, meu amigo, meu chefe e meu exemplo pessoal e profissional. Palavras são parcas para descrever o meu profundo agradecimento não só pelo constante apoio profissional e académico bem como pessoal. Agradeço todas as orientações científicas que me deu na realização deste trabalho bem como todo o rigor e contributo crítico ao longo de toda a minha vida profissional e académica. A sua constante disponibilidade para me auxiliar tornam todas as minhas etapas sempre mais fáceis de superar.Agradeço a todos os meus familiares e amigos por todo o apoio, contributo e incentivo prestado e por estarem sempre presentes quando mais preciso e principalmente por compreenderem os meus momentos de constante ausência. Agradeço especialmente ao André Vieira, Joana Maia, João Pascoal, Carolina Luís, Paulo Carvalho, Tânia Luís, Sérgio Santos, Vítor Hugo, Jair Cruz e Ruben Santos por estarem sempre presentes, mesmo sem pedir nada em troca (às vezes).À Ana Rita por todo o apoio e motivação em todo o meu percurso académico e profissional.Foi graças à sua extrema paciência e compreensão, especialmente quando mais tive ausente, e também do seu contínuo apoio ao longo de todos estes anos que foi possível chegar até aqui.Acreditou sempre no meu valor e deu-me sempre a força necessária para ir superando os meus obstáculos. Obrigado.Ao Alexandre, meu irmão e meu melhor amigo. Por me apoiar incondicionalmente e perdoar todos os meus momentos de ausência. Por me apoiar mesmo sem palavras. Agradeço a boa disposição e acima de tudo o amor de "maninho" com que me presenteia diariamente. v DINO MIGUEL FERNANDES FREITASPor último, aos meus Pais, principalmente por estarem presentes. Por me apoiarem incondicionalmente e darem-me a força necessária para continuar a lutar pelo que quero. Por me alegrarem e animarem nos momentos mais difíceis e por nunca me deixarem baixar os braços acreditando sempre em mim e principalmente por me apoiarem no percurso que escolhi.Agradeço há minha mãe pela amizade de uma amiga e o amor de uma mãe. Agradeço ao meu pai pelos sacrifícios e determinação nas vitórias por quem ama.A todos, o meu mais sincero agradecimento. vi OPTIMIZATION OF A PERFUSION BIOREACTOR FOR TISSUE ENGINEERING ResumoA regeneração de tecidos e/ou de órgãos é a solução para colmatar a falta de órgãos e tecidos, tanto actualmente como num futuro próximo. Este domínio da medicina tem crescido bastante e tem substituído algumas terapias convencionais. Os seus principais objectivos são restaurar, manter ou melhorar as funçõe...

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Biomanufacturing for tissue engineering: Present and future trends

Cited by 140 publications

References 57 publications

Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research

Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research

Experience of Using Individual Titan Implants in Nasal Reconstruction Surgery

Relationship between implant primary stability (torque and ISQ) and bone density assessed by CBCT—clinical trial

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