Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins

Background:Allergic rhinitis (AR) is a common disorder. The diagnosis is based on the concordance between allergy sensitization and history. Serum allergen specific immunoglobulin E (sIgE) assessment allows characterization of the relevant sensitizing allergens. Presently, Allergic Rhinitis and its Impact on Asthma (ARIA) classification subdivides AR based on symptoms severity and duration. However, the relationship between sIgE levels and symptom severity is still a matter of debate.Objective:Therefore, this study aimed at relating sIgE levels with symptom severity assessed by ARIA classification in a group of patients with AR.Methods:We enrolled 217 patients with AR (123 women; median age, 39.5 years). The sIgE levels (expressed in kUA/L) to house-dust mite were detected by the fluorescence enzyme immunoassay in peripheral blood samples. The IgE calibrators were traceable to the second international reference preparation 75/502 of human serum IgE from the World Health Organization. Symptom severity was assessed by ARIA classification.Results:We found a significant difference in sIgE levels in patients with mild intermittent versus mild persistent symptoms (p < 0.05), mild intermittent versus moderate-to-severe persistent symptoms (p < 0.001), moderate-to-severe intermittent versus moderate-to-severe persistent symptoms (p < 0.01), and mild persistent versus moderate-to-severe persistent symptoms (p < 0.05).Conclusion:Analysis of these findings indicated that the sIgE level to house-dust mite might be a reliable biomarker for symptom severity in patients with AR. This outcome might be clinically relevant, particularly in candidates for immunotherapy.

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“…25,26 In addition, the relevance of biomarkers in AR management is an actual issue, as recently pointed out. 27 …”

Section: Discussionmentioning

confidence: 99%

Allergen-Specific Immunoglobulin E and Allergic Rhinitis Severity

Corsico

Amici

Ronzoni

et al. 2017

Allergy�Rhinol (Providence)

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“…Serum IL-17, IL-23, and IL-10 values in children with atopic eczema/dermatitis syndrome have an association with clinical severity and phenotype. 25 …”

Section: Discussionmentioning

confidence: 99%

The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis

Aly

Tabbakh

Heissam

et al. 2017

Allergy�Rhinol (Providence)

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Introduction:Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ∼20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined.Aim:To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition.Patients and Methods:During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed.Results:Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy.Conclusion:These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.

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“…Some evidence suggests that decreased secretion of host defense molecules is associated with CRS (Tieu et al, 2010). Decreased expression levels of palate, lung, and nasal epithelium clone protein (PLUNC), and increased surfactant-B and alpha-defensin levels have been observed in CRSwNP, possibly secondary to loss of glands (Seshadri et al, 2012;Jardeleza et al, 2013;Lin et al, 2016;Tsybikov et al, 2016).…”

Section: Upper Airway Epithelial Functions During Ar and Crsmentioning

confidence: 99%

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Laulajainen‐Hongisto

Toppila‐Salmi

Luukkainen

et al. 2020

Front. Cell Dev. Biol.

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Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

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Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins

Abstract: CR can be categorized by ET-1, TARC/CCL17, neopterin, and α-defensins into several disease phenotypes. Further studies are needed to better investigate pathophysiologic roles of these biomarkers in CRS.

Cited by 22 publications

References 36 publications

Allergen-Specific Immunoglobulin E and Allergic Rhinitis Severity

Allergen-Specific Immunoglobulin E and Allergic Rhinitis Severity

The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

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