Biomarker discovery and beyond for diagnosis of bladder diseases

Jung, Sungyong; Kim, Jayoung

doi:10.14440/bladder.2020.813

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Disease processes occurring in the kidney and bladder can be studied completely non-invasively by analysing changes in biomarkers in urine specimens [ 153 , 370 ]. Urine displays a highly complex metabolome and proteome with a large number of biomolecules that exhibit excellent diagnostic and prognostic properties [ 191 , 369 , 382 ].…”

Section: Introductionmentioning

confidence: 99%

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy

Ohlendieck

Swandulla

2021

Pflugers Arch - Eur J Physiol

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Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to primary abnormalities in one of the largest genes in the human genome, the DMD gene, which encodes various tissue-specific isoforms of the protein dystrophin. Although dystrophinopathies are classified as primary neuromuscular disorders, the body-wide abnormalities that are associated with this disorder and the occurrence of organ crosstalk suggest that a multi-systems pathophysiological view should be taken for a better overall understanding of the complex aetiology of X-linked muscular dystrophy. This article reviews the molecular and cellular effects of deficiency in dystrophin isoforms in relation to voluntary striated muscles, the cardio-respiratory system, the kidney, the liver, the gastrointestinal tract, the nervous system and the immune system. Based on the establishment of comprehensive biomarker signatures of X-linked muscular dystrophy using large-scale screening of both patient specimens and genetic animal models, this article also discusses the potential usefulness of novel disease markers for more inclusive approaches to differential diagnosis, prognosis and therapy monitoring that also take into account multi-systems aspects of dystrophinopathy. Current therapeutic approaches to combat muscular dystrophy are summarised.

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Section: Introductionmentioning

confidence: 99%

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy

Ohlendieck

Swandulla

2021

Pflugers Arch - Eur J Physiol

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The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease

Maden,

Ider,

et al. 2024

BMC Vet Res

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Background Mitochondrial biogenesis (MB) induction has recently emerged as potential therapeutic approaches in kidney pathology and the mitochondria-targeted therapies should be investigated to improve treatment of animals with kidney diseases. This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtration, and reduction of kidney damage and fibrosis (TGF-β/SMAD pathway) in cats with acute on chronic kidney disease (ACKD). Thirty-three cats were divided into the non-azotemic (healthy) group (n:8) and the ACKD group (n:25), comprising different breeds, sexes, and ages. Sildenafil citrate was administered to the non-azotemic and ACKD groups (2.5 mg/kg, PO, q12 hours) for 30 days. Serum and urine NO, MDA, NGAL, KIM-1, TGF-β1, IL-18, FGF 23, PGC-1α and cGMP concentrations were measured. Results Serum cGMP concentrations increased ( P < 0.05 ) in the non-azotemic group during the 2 nd (median 475.99 pmol/mL) and 3 rd (median 405.01 pmol/mL) weeks of the study, whereas serum cGMP concentrations decreased in the ACKD group during the 4 th (median 188.52 pmol/mL) week compared to the non-azotemic group ( P < 0.05 ). No difference was observed in serum biomarker concentrations except NO, which increased in the 4 th week ( P < 0.05 ). The urinary concentrations of NO, MDA, PGC-1α, TGF-β1, NGAL, KIM-1, IL-18, and FGF 23 in the ACKD group were found to be higher compared to those in the non-azotemic group from the 1 st to the 4 th week ( P < 0.05 ). In the ACKD group, the urine PGC-1α concentration in the 2 nd (median 6.10 ng/mL) week was lower compared to that in the 0 and 1 st (median 7.65 and 7.21 ng/mL, respectively) week, and the NO concentration in the 3 rd (median 28.94 µmol/mL) week was lower than that in the 0 th (median 37.43 µmol/mL) week ( P < 0.05 ). Conclusions While sildenafil citrate has been determined to induce a low level of MB and to have a beneficial effect on glomerular filtration, it is observed to be ineffective in mitigating renal damage and fibrosis via the TGF-β/SMAD pathway in cats with ACKD. Supplementary Information The online version contains supplementary material available at 10.1186/s12917-024-04345-9.

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Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?

et al. 2021

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This work will review the metabolic information that various studies have obtained in recent years on bladder cancer, with particular attention to discovering biomarkers in urine for the diagnosis and prognosis of this disease. In principle, they would be capable of complementing cystoscopy, an invasive but nowadays irreplaceable technique or, in the best case, of replacing it. We will evaluate the degree of reproducibility that the different experiments have shown in the indication of biomarkers, and a synthesis will be attempted to obtain a consensus list that is more likely to become a guideline for clinical practice. In further analysis, we will inquire into the origin of these dysregulated metabolites in patients with bladder cancer. For this purpose, it will be helpful to compare the imbalances measured in urine with those known inside tumor cells or tissues. Although the urine analysis is sometimes considered a liquid biopsy because of its direct contact with the tumor in the bladder wall, it contains metabolites from all organs and tissues of the body, and the tumor is separated from urine by the most impermeable barrier found in mammals. The distinction between the specific and systemic responses can help understand the disease and its consequences in more depth.

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Biomarker discovery and beyond for diagnosis of bladder diseases

Cited by 3 publications

References 52 publications

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy

The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease

Urinary Metabolic Markers of Bladder Cancer: A Reflection of the Tumor or the Response of the Body?

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