2018
DOI: 10.1016/j.sjbs.2018.05.027
|View full text |Cite
|
Sign up to set email alerts
|

Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals

Abstract: Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM). We determined the homeostatic model assessment insulin resistance (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in T2DM patients and non-diabetic subjects. This study comprised a total of 47 T2DM patients and 38 non-diabetic controls. Venous blood samples from all the subjects were collected and sera were analyzed for FBG, HbA1c, insulin and C-peptide using… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
19
0
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 32 publications
(21 citation statements)
references
References 39 publications
1
19
0
1
Order By: Relevance
“…High C-peptide levels can imply insulin resistance and finally can lead to type 2 diabetes, atherosclerosis and metabolic syndrome. Thus, it may serve as a biomarker to identify the risk to develop these diseases 35 .…”
Section: Discussionmentioning
confidence: 99%
“…High C-peptide levels can imply insulin resistance and finally can lead to type 2 diabetes, atherosclerosis and metabolic syndrome. Thus, it may serve as a biomarker to identify the risk to develop these diseases 35 .…”
Section: Discussionmentioning
confidence: 99%
“…High C-peptide levels can imply insulin resistance and finally can lead to type 2 diabetes, atherosclerosis and metabolic syndrome. Thus, it may serve as a biomarker to identify the risk of developing these diseases [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…The body mass index (BMI) was calculated as weight (kg)/height(m) −2 . For estimating IR we used: HOMA-IR1 (insulin) = fasting glycemia (mg/dL) * fasting insulin (μUI/mL)/405, HOMA-IR1 (C-peptide) = 1.5 + fasting glycemia (mmol/L)) × (fasting C-peptide (nmol/L)/2800 [ 28 ], and HOMA-IR2 (insulin), HOMA-IR2 (C-peptide) calculated with HOMA-IR software version 2.2.3 available online. The cut-off was set at 2.5 [ 29 ].…”
Section: Methodsmentioning
confidence: 99%