Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC – Hypothesis generation on a multicentre cohort of the DKTK-ROG

Löck, Steffen; Linge, Annett; Lohaus, Fabian; Ebert, Nadja; Gudziol, Volker; Nowak, Alexander; Tinhofer, Ingeborg; Kalinauskaitė, Goda; Guberina, Maja; Stuschke, Martin; Balermpas, Panagiotis; Grün, Jens von der; Grosu, Anca‐Ligia; Debus, Jürgen; Ganswindt, Ute; Belka, Claus; Peeken, Jan C.; Combs, Stephanie E.; De-Colle, Chiara; Zips, Daniel; Baretton, Gustavo; Krause, Mechthild; Baumann, Michaël

doi:10.1016/j.radonc.2022.02.009

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…In the setting of HNSCC, the German Cancer Consortium-Radiation Oncology Group (DKTK-ROG) has described correlations between multiple factors, including tumour p16 status, hypoxia, tumour volume and CSC, and survival 35,167,168 . This group identified biomarker signatures of radioresponse that are currently being assessed in an ongoing prospective observational study (NCT02059668) and will be validated in a planned interventional trial 169 .…”

Section: Future Directionsmentioning

confidence: 99%

Predicting tumour radiosensitivity to deliver precision radiotherapy

2022

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Owing to advances in radiotherapy, the physical properties of radiation can be optimized to enable individualized treatment; however, optimization is rarely based on biological properties and, therefore, treatments are generally planned with the assumption that all tumours respond similarly to radiation. Radiation affects multiple cellular pathways, including DNA damage, hypoxia, proliferation, stem cell phenotype and immune response. In this Review, we summarize the effect of these pathways on tumour responses to radiotherapy and the current state of research on genomic classifiers designed to exploit these variations to inform treatment decisions. We also discuss whether advances in genomics have generated evidence that could be practice changing and whether advances in genomics are now ready to be used

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