2023
DOI: 10.1159/000531444
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Biomarkers for Biodosimetry and Their Role in Predicting Radiation Injury

Abstract: Radiation-related normal tissue injury sustained during cancer radiotherapy or in a radiological or mass casualty nuclear incident is a major health concern. Reducing the risk and mitigating consequences of radiation injury could have a broad impact on cancer patients and citizens. Efforts to discover biomarkers that can determine radiation dose, predict tissue damage, and aid medical triage are underway. Exposure to ionizing radiation causes changes in gene, protein, and metabolite expression that needs to be… Show more

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Cited by 3 publications
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“…In an attempt to address these shortcomings in patient care, research has been conducted to identify biomarkers (metabolites, proteins, etc.) in easily attainable samples (plasma or serum from blood samples) that can possibly assist in pinpointing the absorbed radiation dose in exposed individuals or anticipating health decline so appropriate treatments can be administered 8 , 9 . Biomarkers have been at the forefront of discussion and research within the radiation biology community for several years, as they can potentially exhibit biological processes closely related to the mechanism of disease 4 , 10 , 11 .…”
Section: Introductionmentioning
confidence: 99%
“…In an attempt to address these shortcomings in patient care, research has been conducted to identify biomarkers (metabolites, proteins, etc.) in easily attainable samples (plasma or serum from blood samples) that can possibly assist in pinpointing the absorbed radiation dose in exposed individuals or anticipating health decline so appropriate treatments can be administered 8 , 9 . Biomarkers have been at the forefront of discussion and research within the radiation biology community for several years, as they can potentially exhibit biological processes closely related to the mechanism of disease 4 , 10 , 11 .…”
Section: Introductionmentioning
confidence: 99%
“…However, radiotherapy can damage the surrounding organs at risk (OARs), resulting in treatment interruption and impaired anti-tumor efficacy. Moreover, radiotherapy-related toxicities, such as radiation pneumonia, enteritis, and skin damage, can lead to respiratory failure, diarrhea, and infection, significantly affecting the patient's quality of life and survival [4]. Therefore, exploring methods to reduce these toxicities is a critical focus of research.…”
Section: Introductionmentioning
confidence: 99%