Biomarkers for CNS Injury and Regeneration

Wang, Kevin; Zhang, Zuo‐Feng; Moghieb, Ahmed

doi:10.1016/b978-0-12-801732-6.00026-4

Cited by 2 publications

(2 citation statements)

References 121 publications

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“…Subsequently, the use of mesenchymal stem cells in multiple murine assays has been shown to control the inflammatory process after injury, by inducing the production of neuroprotective factors that promote neuronal survival with consequent improvement in motor function 2,14,15 .…”

Section: Discussionmentioning

confidence: 99%

Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

Garza-Castro

Martı́nez-Rodrı́guez

Sánchez-González

et al. 2018

RIC

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Section: Discussionmentioning

confidence: 99%

Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

Garza-Castro

Martı́nez-Rodrı́guez

Sánchez-González

et al. 2018

RIC

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“…Cell death is a common consequence of cellular structure damage (Manev et al, 1989). As a result, there is an observed rise in the levels of neuronal or astroglial damage biomarkers in serum (Huibregtse et al, 2021;Silvestro et al, 2024;Wang et al, 2015). In cases of brain injury or neurodegenerative conditions, certain markers in the blood, such as S100 calcium-binding protein B (S100B), neuronspecific enolase (NSE), phosphorylated tau217 (pTau217), and glial fibrillary acidic protein (GFAP), have been found to be elevated (Brenner, 2014;das Neves et al, 2021;Palmqvist et al, 2020;Palumbo et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

In Parkinson’s disease, affective and chronic fatigue syndrome symptoms are associated with neuronal damage markers

Al-Hakeim,

Khudhair,

Ranaei-Siadat

et al. 2024

Preprint

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Background. Parkinson's disease (PD) is frequently accompanied by mood and chronic fatigue syndrome (CFS) symptoms. It is unknown whether immune activation and insulin resistance (IR) or brain injuries impacts the severity of affective and CFS symptoms due to PD. Aims. To examine whether immune, IR, and/or brain injury biomarkers determine affective and CFS symptoms due to PD. Methods. Using a case (70 PD patients) control (60 healthy controls) study design, we assessed affective and CFS symptoms, measured the peripheral immune-inflammatory response system (IRS) using interleukin-6 (IL-6), IL-10, zinc, and calcium levels, the Homeostasis Model Assessment 2 insulin resistance (HOMA2IR) index, and serum brain injury markers including S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), phosphorylated tau217 (pTau217), and glial fibrillary acidic protein (GFAP). Results. PD patients showed increased affective and CFS scores, IRS activation, HOMA2IR, NSE, GFAP, pTau217, and S100B levels as compared to controls. A large part (52.5%) of the variance in the mood+CFS score was explained by the regression on NSE, S100B, HOMA2IR index, interleukin-10 (IL-10) (all positively) and calcium (inversely). The HOMA2IR and IRS indices were significantly associated with all 4 brain injury biomarkers. A large part of the variance in the latter markers (37.0%) was explained by the cumulative effects of the IRS and HOMA2IR indices. Discussion. IRS activation and IR in patients with PD contribute to damage to glial cell projections and type III intermediate filament, which in turn contribute to affective and CFS symptoms.

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Biomarkers for CNS Injury and Regeneration

Cited by 2 publications

References 121 publications

Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model

In Parkinson’s disease, affective and chronic fatigue syndrome symptoms are associated with neuronal damage markers

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