Biomarkers for Monitoring Response to Therapies and Detection of Acquired Resistance in Advanced Gastrointestinal Cancers

Hahne, Jens C.; Mirchev, Milko; Kotzev, Iskren; Lampis, Andrea; Valeri, Nicola

doi:10.2174/9781681084817117040003

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple lines of evidence suggest that tissue-and disease-specific miRNA signatures may be used as biomarkers for diagnostic, prognostic and predictive purposes in the clinic [46,[52][53][54][55][56][57][58]. However, the most exciting avenue of current translational research efforts is focusing on their therapeutic potential [59][60][61][62][63][64].…”

Section: Micrornasmentioning

confidence: 99%

“…Furthermore, miRNAs and lncRNAs are present also in exosomes, which protect them from degradation within body fluids [135]. Therefore, tissues as well as liquid biopsies can be used as starting material for exploring the potential of both non-coding RNA classes as biomarkers and they are already widely used as biomarkers in cardiac and neural diseases as well as cancer [13,53,105,[136][137][138]].…”

Section: Use Of Micrornas and Long Non-coding Rnas As Clinical Biomarmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

et al. 2020

Self Cite

View full text Add to dashboard Cite

Non-coding RNAs represent a significant proportion of the human genome. After having been considered as 'junk' for a long time, non-coding RNAs are now well established as playing important roles in maintaining cellular homeostasis and functions. Some non-coding RNAs show cell-and tissue-specific expression patterns and are specifically deregulated under pathological conditions (e.g. cancer). Therefore, non-coding RNAs have been extensively studied as potential biomarkers in the context of different diseases with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) for several years. Since their discovery, miRNAs have attracted more attention than lncRNAs in research studies; however, both families of non-coding RNAs have been established to play an important role in gene expression control, either as transcriptional or post-transcriptional regulators. Both miRNAs and lncRNAs can regulate key genes involved in the development of cancer, thus influencing tumour growth, invasion, and metastasis by increasing the activation of oncogenic pathways and limiting the expression of tumour suppressors. Furthermore, miRNAs and lncRNAs are also emerging as important mediators in drug-sensitivity and drug-resistance mechanisms. In the light of these premises, a number of pre-clinical and early clinical studies are exploring the potential of non-coding RNAs as new therapeutics. The aim of this review is to summarise the latest knowledge of the use of miRNAs and lncRNAs as therapeutic tools for cancer treatment.

show abstract

Section: Micrornasmentioning

confidence: 99%

Section: Use Of Micrornas and Long Non-coding Rnas As Clinical Biomarmentioning

confidence: 99%

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Selenium can boost the immune system by enhancing the role of natural killer cells and T lymphocytes. Also, it has shown some antiviral activities [35]. The main consideration of selenium is its toxicity in high doses.…”

Section: Selenium Nanoparticles and Ebselenmentioning

confidence: 99%

Exploring the Role of Heavy Metals and Their Derivatives on the Pathophysiology of COVID-19

Bahrami

Arabestani

Taheri

et al. 2021

Biol Trace Elem Res

View full text Add to dashboard Cite

Many aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease, COVID-19, have been studied to determine its properties, transmission mechanisms, and pathology. These efforts are aimed at identifying potential approaches to control or treat the disease. Early treatment of novel SARS-CoV-2 infection to minimize symptom progression has minimal evidence; however, many researchers and firms are working on vaccines, and only a few vaccines exist. COVID-19 is affected by several heavy metals and their nanoparticles. We investigated the effects of heavy metals and heavy metal nanoparticles on SARS-CoV-2 and their roles in COVID-19 pathogenesis. AgNPs, AuNPs, gold-silver hybrid NPs, copper nanoparticles, zinc oxide, vanadium, gallium, bismuth, titanium, palladium, silver grafted graphene oxide, and some quantum dots were tested to see if they could minimize the severity or duration of symptoms in patients with SARS-CoV-2 infection when compared to standard therapy.

show abstract

Interaction between HOTTIP, H19, and HOTAIR long noncoding RNAs and miRNA-152 in cases of HCC caused by HCV infection

El-Araby,

Roshdy,

Zaghloul

et al. 2024

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

Background Liver cancer (hepatocellular carcinoma “HCC”) remains a significant health issue without prompt detection and appropriate prevention. By interacting with each other, long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) can form gene regulatory networks. Specifically, we aim to determine whether the lncRNAs (HOTTIP, H19, and HOTAIR) and miRNA-152 interact in a significant manner in the progression of Hepatitis C virus (HCV) patients to HCC. This is followed by the question of whether these biomarkers can be used to diagnose and prognose noninvasively. We used online computational techniques to predict which miRNA group is likely to affect the lncRNAs being examined. This study involved 133 participants. 103 patients with HCV were included in the study, which was divided into two groups: Group I, with 65 cases of chronic liver disease without HCC, and Group II, with 38 cases of chronic liver disease with HCC. In addition, 30 healthy volunteers served as controls. In this study, a qRT-PCR was used to test gene expression. Results A consistent reverse correlation has been observed between lncRNAs and miRNA-152 as the disease progresses. Conclusion According to our findings, the studied biomarkers may be useful as noninvasive biomarkers for prognosis in patients with HCV Genotype 4 who develop liver cirrhosis and HCC. Many miRNAs, including miRNA-19a and miRNA-106a, may interact with lncRNAs that have been investigated in addition to miRNA-152.

show abstract

Biomarkers for Monitoring Response to Therapies and Detection of Acquired Resistance in Advanced Gastrointestinal Cancers

Cited by 3 publications

References 0 publications

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

Exploring the Role of Heavy Metals and Their Derivatives on the Pathophysiology of COVID-19

Interaction between HOTTIP, H19, and HOTAIR long noncoding RNAs and miRNA-152 in cases of HCC caused by HCV infection

Contact Info

Product

Resources

About