Biomarkers in COPD- The role of resistin and leptin

Vitsas, Vlasios; Kardara, Matina; Aliki, Vasileiou; Koutsoukou, Antonia; Michalopoulou, P.; Stylianos, Orfanos; Tsoukalas, Georgios; Kotanidou, Anastasia

doi:10.1183/13993003.congress-2015.pa691

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leptin plays a key role in the regulation of energy homeostasis; increasing evidence suggests that it is also critical for glycemic control, acting as a potential mediator to normalize glycaemia in states of uncontrolled insulin-deficient diabetes [ 33 ]. However in women with COPD-BS were observed higher levels of insulin and leptin, which seems not be enough to diminish hyperinsulinemia and hyperglycemia, which the high risk of develop T2DM and other pathogenic effects is maintained [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

et al. 2018

View full text Add to dashboard Cite

BackgroundThe main causes of COPD are tobacco smoking (COPD-TS) and biomass smoke exposure (COPD-BS). COPD-TS is known to induce changes in adipokines, incretins, and peptide hormones, frequent biomarkers of inflammation; however, it is unknown if similar changes occur in COPD-BS.MethodsClinical and physiological characteristics, and serum concentration of C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin were measured in women with COPD-BS, COPD-TS, and healthy controls.Data were compared with one-way ANOVA and Tukey’s post hoc test; nonparametric were expressed as median (interquartile ranges), with Kruskal-Wallis and Dunn’s post-hoc test. Multivariate analysis, age, BMI, MS, and FEV1% pred with levels of inflammatory mediators in COPD women.ResultsFEV1% pred, FVC% pred, and FEV1/FVC ratio were decremented in COPD. In COPD-TS increased C-peptide, ghrelin, GIP, GLP-1, and leptin, and reduced glucagon, PAI-1, resistin, and visfatin. In COPD-BS enlarged ghrelin, insulin, leptin, and PAI-1 comparatively with COPD-TS and control, while C-peptide and GLP-1 relatively with controls; conversely, glucagon, and resistin were reduced. Multivariate analysis showed association of ghrelin, insulin, PAI-1, and visfatin with BS exposure.Conclusionswomen with COPD-BS have a distinct profile of adipokines, incretins, and peptide hormones, and specifically with ghrelin, insulin, PAI-1, and visfatin related to BS exposure.

show abstract

Section: Discussionmentioning

confidence: 99%