Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Pérez-Bautista, Oliver; Montaño, Martha; Pérez‐Padilla, Rogelio; Zúñiga-Ramos, Joaquín; Camacho-Priego, Mariana; Barrientos‐Gutiérrez, Tonatiuh; Buendía-Roldán, Ivette; Velasco-Torres, Yadira; Ramos, Carlos

doi:10.1186/s12931-018-0943-4

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…Therefore, is less likely than men develop COPD from this cause. COPD-diagnosed women have an inflammation profile that is higher than normal control levels, as is evidenced by higher plasma CRP (C-reactive protein), glucose, and several inflammatory mediators, such as adipokines, incretins, and peptide hormones [18]. This supports the fact that COPD-BS and COPD-TS could represent different phenotypes of COPD [2,3].…”

Section: Discussionmentioning

confidence: 63%

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and systemic inflammation. The main causes of COPD include interaction between genetic and environmental factors associated with tobacco smoking (COPD-TS) and/or exposure to biomass smoke (COPD-BS). Several microRNAs (miRNAs) control posttranscriptional regulation of COPD-TS associated gene expression. The miR-22-HDAC4-IL-17 axis was recently characterized. It is still unknown, however, whether this axis, participates in COPD-BS. To investigate, 50 patients diagnosed with severe-to-very severe COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages III/IV, were recruited, 25 women had COPD-BS (never smokers, exposed heavily to BS) and 25 had COPD-TS. Serum levels of miRNA-22-3p were measured by RT (Reverse Transcription)-qPCR, while the concentration of HDAC4 (Histone deacetylase 4) was detected by ELISA. Additionally, we looked for association between serum HDAC4 and DLCOsb (Single-breath diffusing capacity of the lung for carbon monoxide), as % of predicted by age, height, and gender, one of the main differences described between COPD-BS and COPD-TS. Women with COPD-BS were older and shorter and had a higher DLCOsb %P (percent predicted) compared to COPD-TS. Serum miR-22-3p was downregulated in COPD-BS relative to COPD-TS. In contrast, the concentration of HDAC4 was higher in COPD-BS compared to COPD-TS. Furthermore, a positive correlation between serum HDAC4 levels and DLCOsb %P was observed. We concluded that the miR-22-HDAC4-DLCO axis behaves differently in patients with COPD-BS and COPD-TS.

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Section: Discussionmentioning

confidence: 63%

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

et al. 2019

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“…In addition, there is evidence that the concentrations of insulin, C-peptide, leptin and the glucose/insulin ratio are associated with recurrent wheezing in preschool children [ 36 ]. A number of studies indicate an increase in the level of C-peptide in patients with COPD [ 37 , 38 , 39 ]. At the same time, none of the studies evaluated the level of C-peptide and insulin in individuals with combined pathology of AO and bronchitis.…”

Section: Discussionmentioning

confidence: 99%

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

et al. 2022

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The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.

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“…In the case of neutrophils, there is no evidence about the direct effect of corticosteroids/glucocorticoids in these cells. On the other hand, neutrophils could be stimulated by environmental pollution or smoking [81][82][83][84]. Recent research into the cellularity that characterizes asthma has allowed proposing the classification and study of the disease based on the dominance of certain strains [72].…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population

et al. 2020

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Background: Asthma is a complex and chronic inflammatory airway disease. Asthma’s etiology is unknown; however, genetic and environmental factors could affect disease susceptibility. We designed a case-control study aimed to evaluate the role of single-nucleotide polymorphisms (SNP), and copy-number variants (CNV) in the IL4 and IL13 genes in asthma susceptibility and their participation in plasma cytokine levels depending on genotypes Methods: We include 486 subjects, divided into asthma patients (AP, n = 141) and clinically healthy subjects (CHS, n = 345). We genotyped three SNP, two in the IL4 and two in the IL13 gene; also, two CNVs in IL4. The IL-4, IL-13 and IgE plasma levels were quantified. Results: Biomass-burning smoke exposure was higher in the AP group compared to CHS (47.5% vs. 20.9%; p < 0.01, OR = 3.4). No statistical differences were found in the genetic association analysis. In both CNV, we only found the common allele. For the analysis of IL-4, IL-13, and IgE measures stratified by genotypes, no significant association or correlation was found. Conclusion: In the Mexican-mestizo population, SNPs neither CNVs in IL4 nor IL13 are associated with asthma susceptibility or involved serum cytokine levels. Biomass-burning smoke is a risk factor in asthma susceptibility.

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Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Cited by 10 publications

References 37 publications

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population

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