Biomarkers in epidemiological and toxicological nutrition research

Poppel, G. van; Verhagen, Hans; Heinzow, Birger

doi:10.1007/978-1-4613-1111-9_4

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…The biologically effective dose represents a relevant interaction between a substance and a body component. It can be defined as the amount of material interacting with subcellular, cellular and tissue targets or with an established surrogate (van Poppel et al 1997). Among the various markers of biologically effective dose of aflatoxins, the measurement of DNA adducts (e.g.…”

Section: Biomarkers Of Exposurementioning

confidence: 99%

“…Along the whole path from exposure to disease, the level of exposure plays a role but also there is genotypic or phenotypic predisposition. A sensitivity/susceptibility marker determines an individual's inherited or acquired trait that may predispose them to an increased risk of developing disease (van Poppel et al 1997). Cytochrome P450 3A4 is a major hepatic enzyme involved in the bioactivation of AFB 1 , benzo[a]pyrene diol epoxide and several other carcinogens.…”

Section: Biomarkers Of Susceptibilitymentioning

confidence: 99%

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A critical assessment of some biomarker approaches linked with dietary intake

Crews¹,

Alink²,

Andersen

et al. 2001

Br J Nutr

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Section: Biomarkers Of Exposurementioning

confidence: 99%

Section: Biomarkers Of Susceptibilitymentioning

confidence: 99%

A critical assessment of some biomarker approaches linked with dietary intake

Crews¹,

Alink²,

Andersen

et al. 2001

Br J Nutr

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“…Moreover, only relatively few samples can be measured. In addition, epidemiological studies cannot overcome inter-and intraindividual differences in intake of bioactive substances (van Poppel et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring the intake of garlic via urinary excretion of allyl mercapturic acid

et al. 2001

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Allium vegetables (onions, leeks, chives) and in particular garlic have been claimed to have health-promoting potential. This study was conducted to get insight into the perspectives for monitoring the intake of garlic by a biomarker approach. Chemically, the biomarker results from exposure to g-glutamyl-S-allyl-L-cysteine, which is first hydrolysed by g-glutamine-transpeptidase resulting in the formation of S-allyl-L-cysteine. The latter compound is subsequently N-acetylated by N-acetyltransferase into S-allyl-mercapturic acid (ALMA) and excreted into urine. The mercapturic acid was measured in urine using gaschromatography with mass spectrometry. Thus the intake of garlic was determined to check the compliance of garlic intake in a placebo-controlled intervention study. Results indicate that S-allyl-mercapturic acid could be detected in 15 out of 16 urine samples of garlic supplement takers, indicating good compliance. In addition, the intake of garlic was also monitored in a cross-section study of vegans versus controls in Finland, in which no differences in garlic consumption nor in ALMA output were recorded between vegans and controls. These data indicate good possibilities for further studies in the field of biomarkers to investigate the putative chemopreventive effects of garlic and garlic-containing products.

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“…Biomarker research has attracted much interest in recent years. So far, biomarkers have been used predominantly in environmental and occupational toxicology studies, but they could also play an important role in nutritional research (48).…”

Section: Use Of Biomarkers In Food Additives Testingmentioning

confidence: 99%