Biomarkers in Solid Organ Transplantation

Choi, John Y.; Bano, Albana; Azzi, Jamil

doi:10.1016/j.cll.2018.11.003

Cited by 10 publications

(7 citation statements)

References 107 publications

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“…The precision medicine model, which integrates clinical, molecular, and genetic data to achieve a clinical management that is tailored to the specific characteristics and risks of each patient, is emerging as the most effective health care strategy [ 30 , 31 ]. This is particularly evident in LT candidates with HCC, where the pathogenic interaction among tumor cells, the patient’s immune system and metabolic function, surgical invasiveness, and post-LT immunosuppressant therapies is very tight and has significant implications for long-term outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…This is particularly evident in LT candidates with HCC, where the pathogenic interaction among tumor cells, the patient’s immune system and metabolic function, surgical invasiveness, and post-LT immunosuppressant therapies is very tight and has significant implications for long-term outcomes. Biomarkers are the cornerstone of precision medicine, but their identification as well as their real clinical effectiveness depend on the exact understanding of the disease pathogenesis [ 30 , 31 ]. Therefore, further studies will be surely warranted to explore in particular the potential association between inflammatory biomarkers and circulating tumor cells or distant micrometastasis, as well as to identify those post-LT clinical factors which significantly sustain a persistent pro-inflammatory state in LT recipients.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative Trends and Prognostic Values of Inflammatory and Nutritional Biomarkers after Liver Transplantation for Hepatocellular Carcinoma

Pravisani

Mocchegiani

Isola

et al. 2021

Cancers

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Preoperative inflammatory biomarkers such as the Platelet-to-Lymphocyte Ratio (PLR) and the Neutrophil-to-Lymphocyte Ratio (NLR) strongly predict the outcome in surgically treated patients with hepatocellular carcinoma (HCC), while nutritional biomarkers such as the Controlling Nutritional Status (CONUT) and the Prognostic Nutritional Index (PNI) show an analogue prognostic value in hepatic resection (HR) but not in liver transplant (LT) cases. Data on the impact of LT on the inflammatory and nutritional/metabolic function are heterogeneous. Therefore, we investigated the post-LT trend of these biomarkers up to postoperative month (POM) 12 in 324 HCC patients treated with LT. Inflammatory biomarkers peaked in the early post-LT period but at POM 3 leveled off at values similar (NLR) or higher (PLR) than pre-LT ones. CONUT and PNI worsened in the early post-LT period, but at POM 3 they stabilized at significantly better values than pre-LT. In LT recipients with an overall survival >1 year and no evidence of early HCC recurrence, 1 year post-LT NLR and PNI independently predicted patient overall survival, while 1 year post-LT PLR independently predicted late tumor recurrence. In conclusion, at 1 year post-LT, the nutritional status of liver-transplanted HCC patients significantly improved while their inflammatory state tended to persist. Consequently, post-LT PLR and NLR maintained a prognostic value for LT outcome while post-LT CONUT and PNI acquired it.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Postoperative Trends and Prognostic Values of Inflammatory and Nutritional Biomarkers after Liver Transplantation for Hepatocellular Carcinoma

Pravisani

Mocchegiani

Isola

et al. 2021

Cancers

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“…The identification of predictive factors involved in allograft rejection continues as an important research topic to improve long term allograft survival and to establish personalized therapies. To date, no good biomarkers exist to predict post-transplant complications ( 32 ); therefore genetic polymorphisms could be a useful tool.…”

Section: Introductionmentioning

confidence: 99%

Association of Polymorphisms in T-Cell Activation Costimulatory/Inhibitory Signal Genes With Allograft Kidney Rejection Risk

et al. 2021

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The genes CD28, CD86 and CTLA-4 conform the costimulatory (CD28-CD86) or inhibitory (CTLA-4-CD86) signal in T-cell activation. T-cell immune response has a critical role in allograft rejection, and single nucleotide polymorphisms (SNPs) located in these genes have been widely analyzed with controversial results. We analyzed a group of SNPs located in the three genes: CD28: rs3116496; CD86: rs1129055; and CTLA-4: rs231775 and rs3087243 in a cohort of 632 consecutively recruited kidney transplanted subjects. All polymorphisms were genotyped by TaqMan chemistry and the diagnosis of rejection was confirmed by biopsy and categorized according to the Banff classification. The analyses showed a statistically significant protective effect to T cell-mediated rejection (TCMR) in carriers of the CTLA-4 rs3087243*G allele, especially in patients with TCMR Banff ≥2 in the overall cohort and in patients without thymoglobulin induction therapy. Both associations were corroborated as independent factors in the multivariate analysis. Interestingly, associations with rejection were not found for any SNP in patients with thymoglobulin induction therapy. As expected, considering the major role of these genes in T-cell activation, no effect was observed for antibody-mediated rejection (ABMR). In conclusion, the SNP rs3087243 located in the CTLA-4 gene may be considered a useful independent biomarker for TCMR risk especially for severe TCMR in patients who did no received thymoglobulin induction therapy.

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“…On the other hand, the majority of studies addressed the more exciting question namely how dd-cfDNA serves as a rejection biomarker. Several reviews have summarized these studies [72,80,81,82,83]. Out of these, in their recent systematic review, Knight et al [84] published a large collection of relevant literature searches.…”

Section: Role Of Microchimerism In Solid Organ Transplantationmentioning

confidence: 99%

Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation

Andrikovics

Őrfi

Meggyesi

et al. 2019

IJMS

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Primarily due to recent advances of detection techniques, microchimerism (the proportion of minor variant population is below 1%) has recently gained increasing attention in the field of transplantation. Availability of polymorphic markers, such as deletion insertion or single nucleotide polymorphisms along with a vast array of high sensitivity detection techniques, allow the accurate detection of small quantities of donor- or recipient-related materials. This diagnostic information can improve monitoring of allograft injuries in solid organ transplantations (SOT) as well as facilitate early detection of relapse in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the present review, genetic marker and detection platform options applicable for microchimerism detection are discussed. Furthermore, current results of relevant clinical studies in the context of microchimerism and SOT or allo-HSCT respectively are also summarized.

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Biomarkers in Solid Organ Transplantation

Abstract: In this review, we explore the laboratory process and clinical application of selective biomarkers. Finally, we introduce novel biomarkers that were recently discovered and are undergoing validation.

Cited by 10 publications

References 107 publications

Postoperative Trends and Prognostic Values of Inflammatory and Nutritional Biomarkers after Liver Transplantation for Hepatocellular Carcinoma

Postoperative Trends and Prognostic Values of Inflammatory and Nutritional Biomarkers after Liver Transplantation for Hepatocellular Carcinoma

Association of Polymorphisms in T-Cell Activation Costimulatory/Inhibitory Signal Genes With Allograft Kidney Rejection Risk

Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation

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