Biomarkers in the diagnosis of acute appendicitis

Abstract

Objective: Patients who is presented to ED with the complaint of abdominal pain account an important number in the ED practice. Availability of rapid and inexpensive tests is crucial in the differential diagnosis of these patients. Hemogram parameters is one of them. In this study, we investigated the biomarkers in hemogram parameters of the patients diagnosed with acute appendicitis.Methods: Data of 520 patients who were operated with the presumed diagnosis of appendicitis in our hospital between 01/01/2012 and 31/12/2013 were retrospectively screened. Of the 410 patients whom data were fully reached, leukocyte, neutrophil and lymphocyte counts, neutrophil / lymphocyte ratio (NLR), pathology results and at the admission time and superficial tissue ultrasonography (USG) reports if further investigation has been made were recorded.Results: According to the pathological diagnosis of 334 patients (81.5%), while appendicitis 76 patients (18.5%) was not appendicitis. When taken 11,6 x10 3 for leukocyte, 8.5 x10 3 for neutrophil, 3.9 for NLO, while specificity of total was 78.8%, sensitive 73.6% was found. Conclusion:Together evaluation of neutrophils, lymphocytes and NLR which are routinely used hemogram parameters in association of physical examination is seem to be more appropriate.

Predictive Value of Neutrophil/Lymphocyte Ratios in the Diagnosis of Acute Appendicitis

“…The mean age of the patients included in our study did not differ statistically between the groups. In accordance with the studies in the literature, male sex was dominant in the acute appendicitis group and male/female ratio was similar in the negative appendectomy group (9,13,17) . The negative appendectomy rate was 19.7% in female patients.…”

“…In studies investigating the diagnostic value of NLR, for negative appendectomy was reported to be between 12.9-18.5% (8,9,13,17,21) .In our series, this rate was found to be 17.1%.…”

“…In general, finding suitable, easily accessible and cost-effective diagnostic markers for early detection of diseases has always been the focus of interest of researchers. Many markers that can be used for early diagnosis were investigated because of morbidity and mortality caused by delayed diagnosis in patients followed up for acute abdominal pain in the emergency departments (9,10,13,17) .…”