Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method

Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart‐Protecting Musk Pill on IL‐6 and TNF‐Alpha

“…Modern pharmacology studies found that the component drugs of HMP were effective in antiplatelet aggregation, strengthening heart, vasodilatation, reducing inflammation, and analgesia [9–12]. Furthermore, some studies found that HMP can diminish the myocardial infarction areas in AMI rats model, promote the angiogenesis, and improve cardiac function of AMI patients [7, 13]. As a highly valued traditional medicine, Moschus is used extensively for the treatment of cardiocerebrovascular diseases.…”

“…The synergistic actions of all these drugs have the effect of warming up the heart Yang, activating blood circulation, eliminating phlegm, relieving pain, benefiting cardiac Qi, and protecting heart. By numerous animal experiments and clinical studies, it is proved that HMP is capable of dilating coronary artery, reducing the myocardial infarcted size, preventing ventricular reconstitution, inhibiting the inflammation of blood-vessel wall, and stabilizing atherosclerosis plaques [6, 7]. …”

A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry

“…It has previously been shown that lung infections with different microorganisms in mouse models induce unique metabolite patterns in urine and plasma (Lu et al, 2012;Slupsky et al, 2009a;Slupsky et al, 2009b). In recent years, an increasing number of studies have investigated the holistic therapeutic effects of TCM scientifically, via metabolomics (Dai et al, 2010;Jiang et al, 2011;Zhang et al, 2014;Zhao et al, 2015).…”

UHPLC-MS for the analytical characterization of traditional Chinese medicines

“…Metabolomics seeks to elucidate the therapeutic properties and metabolism of prescription drugs and the metabolic pathways involved [81][82][83][84][85][86][87][88][89][90][91][92]. It will greatly facilitate understanding of the mechanisms of action of TCMs [93][94][95][96][97][98][99][100][101][102].…”