Biomarkers of cardiometabolic health and nutritional status in individuals with positive celiac disease serology

Jamnik, Joseph; Jenkins, David; El‐Sohemy, Ahmed

doi:10.1177/0260106017748053

Cited by 7 publications

(7 citation statements)

References 55 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-chain (C20–22) PUFAs are important for optimal metabolism while deficiencies might contribute to the disease onset, including psychiatric diseases and depression that, indeed, are manifestations usually reported by U-CD ( De Palma et al, 2014 ; Jelsness-Jørgensen et al, 2018 ). Impairments in FAs determined by CD were also argued by Jamnik et al (2018) . This research group showed that U-CD had a lower level of circulating HDL-cholesterol and apolipoprotein-A1.…”

Section: Discussionmentioning

confidence: 90%

“…The lipidomics based on GC-flame ionization detector (FID) assessed higher ratios of palmitic, palmitoleic, stearic, and oleic acids, as well as lower ratios of linoleic, alpha-linolenic, dihomo-gamma-linolenic, arachidonic, eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids than those of HC. Instead, Jamnik et al (2018) deeply profiled biochemical biomarkers of cardiometabolic health and nutritional status in blood. Compared to those with negative CD serology, U-CD had a lower level of circulating HDL-cholesterol and apolipoprotein-A1.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Celiac disease (CD) is an inflammatory autoimmune disorder triggered by the ingestion of gluten from wheat and other cereals. Nowadays, its positive diagnosis is based on invasive approaches such as the histological examination of intestinal biopsies and positive serology screening of antibodies. After proven diagnosis, the only admissible treatment for CD individuals is strict life-long adherence to gluten-free diet (GFD), although it is not a conclusive therapy. Acting by different mechanisms and with different etiologies, both CD and GFD have a great impact on gut microbiota that result in a different taxa composition. Altered production of specific metabolites reflects these microbiota changes. In this light, the currently available literature reports some suggestions about the possible use of specific metabolites, detected by meta-omics analyses, as potential biomarkers for a CD non-invasive diagnosis. To highlight insights about metabolomics application in CD study, we conducted a narrative dissertation of selected original articles published in the last decade. By applying a systematic search, it clearly emerged how the metabolomic signature appears to be contradictory, as well as poorly investigated.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, we believe that, in our patient, vitamin C deficiency can be ascribed only to a lack of intake because vitamin C levels are not usually altered in patients affected by celiac disease. 23 No zinc supplementation was started because of the absence of clinical changes related to zinc deficiency.…”

Section: Discussionmentioning

confidence: 99%

Scurvy: A Disease not to be Forgotten

et al. 2020

View full text Add to dashboard Cite

An 18-year-old man presented to our hospital with muscular pain, diffuse petechiae, spontaneous thigh ecchymosis, edema and pain of the right knee, bilateral pretibial subcutaneous nodules, and gingival hypertrophy and hemorrhage. His history was positive for a mixed anxiety-depressive disorder and a restrictive diet caused by self-diagnosed food allergies. Skin lesions appeared like hyperkeratotic papules with coiled hairs and perifollicular hemorrhages. A diagnosis of scurvy was made upon demonstration of low serum levels of ascorbic acid. An allergy evaluation found cross-reactivity between pollens and food, related to the presence of panallergens. Moreover, we found that our patient was also affected by celiac disease. In conclusion, scurvy should be considered in the differential diagnosis of patients with petechiae and ecchymosis, especially when food restriction, malabsorption, or psychiatric disorders are present.

show abstract

“…Bile flow rate and the secretion of biliary of its main components, such as cholesterol, phospholipids, and bile acids, were reported to be significantly increased in active CD and be normalized after effective GFD. [ 18 ] This enhanced secretion of newly synthesized and/or absorbed cholesterol directly into the bile has been associated with a decrease in serum cholesterol concentration in CD patients, [ 19 ] which has been observed both in pediatric and adult clinical studies [ 20 , 21 , 22 ]. However, total plasma cholesterol is often associated with a decrease in HDL-cholesterol and, thus, a higher ratio of total cholesterol to HDL-cholesterol, which can also be ameliorated through GFD [ 22 , 23 ].…”

Section: Gallbladder Functioning and Regulation In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Gallbladder: Pathophysiological Aspects and Clinical Issues

et al. 2022

View full text Add to dashboard Cite

Background: Celiac Disease (CD) is an immune-mediated disorder which primarily affects the small intestine; however, extra-intestinal organs are often affected by the pathological process, too. As regards the digestive system, liver alterations in CD patients have been widely described, which can also extend to the biliary tract. Notably, gallbladder function can be altered in CD patients. In this review, we specifically analyze and summarize the main pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, in order to discuss the potential medical complications and clinical research gaps. In addition to some perturbations of bile composition, CD patients can develop gallbladder dysmotility, which mainly expresses with an impaired emptying during the digestive phase. The main pathophysiological determinant is a perturbation of cholecystokinin secretion by the specific duodenal enteroendocrine cells in response to the appropriate nutrient stimulation in CD patients. This situation appears to be reversible with a gluten-free diet in most cases. Despite this gallbladder impairment, CD patients do not seem to be more predisposed to gallbladder complications, such as calculous and acalculous cholecystitis. However, very few clinical studies have actively investigated these clinical aspects, which may not be completely evidenced so far; alternatively, the substantial improvements in the last two decades regarding CD diagnosis, which have reduced the diagnostic delay (and related dietary treatment), may have lessened the potential clinical consequences of CD-related gallbladder dysfunction. Specific clinical studies focused on these aspects are needed for a better understanding of the clinical implications of gallbladder alterations in CD patients.

show abstract

Biomarkers of cardiometabolic health and nutritional status in individuals with positive celiac disease serology

Abstract: Individuals with undiagnosed CD may have unfavorable lipid profiles and be at elevated risk for inadequacy of certain fat-soluble vitamins, but not widespread nutrient deficiencies.

Cited by 7 publications

References 55 publications

How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review

How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review

Scurvy: A Disease not to be Forgotten

Celiac Disease and Gallbladder: Pathophysiological Aspects and Clinical Issues

Contact Info

Product

Resources

About