Biomarkers of connective tissue disease in patients with intracranial aneurysms

Yurt, Alaattin; Vardar, Enver; Selçukı, Mehmet; Ertürk, Ali; Özbek, Gülriz; Atçı, Burak

doi:10.1016/j.jocn.2010.01.028

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Assessor at this study was not blinded for patients and controls. Yurt et al (14) examined 62 patients with SIA. They found that patients with SIA had a higher incidence of biomarkers of systemic connective tissue disease than controls.…”

Section: Discussionmentioning

confidence: 99%

Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

Lebedeva

Сакович

2013

Acta Neurol Scand

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Section: Discussionmentioning

confidence: 99%

Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

Lebedeva

Сакович

2013

Acta Neurol Scand

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“…44 Moreover, we have identified significant associations between CA susceptibility and genetic variants for 2 other members of the ADAMTS family. The ADAMTS12 variant rs1364044 seems to offer a protective effect against CA pathogenesis, while the ADAMTS13variants rs2285489andrs2301612conferasignificantriskforde-velopingCAs.…”

Section: 38mentioning

confidence: 92%

ADAMTS genes and the risk of cerebral aneurysm

Arning

Jeibmann²,

Köhnemann

et al. 2016

JNS

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C erebral aneurysms (CAs) are dilations of cerebral arteries that affect 2%-5% of the population. 35 Although most of these lesions are clinically unapparent, CA rupture and subarachnoid hemorrhage usually occur between 40 and 60 years of age. Therefore, early identi fication of a CA is essential for preventing subsequent bleeding events, which often lead to substantial morbidity and mortality. 4,16 The pathogenesis of CA formation and rupture is complex and seems to arise from multiple factors. A familial predispositionisthestrongestriskfactorforthedevelopment of a CA; siblings of patients with CA are at a 4-fold increased risk of hemorrhage, 40 suggesting a significant genetic component to CA pathogenesis. 37Environmental factors,suchassmoking,hypertension,andextensivealcohol intake, appear to play a more important role in the abbreviatioNs CA = cerebral aneurysm; FDR = false discovery rate; GWAS = genome-wide association study; HWE = Hardy-Weinberg equilibrium; ICB = intracerebral bleeding; IS = ischemic stroke; MI = myocardial infarction; MMP = matrix metalloproteinase; PS = pediatric stroke; SAB = subarachnoidal bleeding; SNP = single nucleotide polymorphism; TSR = thrombospondin Type 1 sequence repeat motif. submitted January 2, 2015. methods To identify susceptible genetic variants, the authors investigated 8 single nucleotide polymorphisms (SNPs) in 4 genes from the ADAMTS family (ADAMTS2, -7, -12, and -13) known to be associated with vascular diseases. The study included 353 patients with CAs and 1055 healthy adults. results The authors found significant associations between CA susceptibility and genetic variations in 3 members of the ADAMTS family. The largest risk for CA (OR 1.32, p = 0.006) was observed in carriers of the ADAMTS2 variant rs11750568, which has been previously associated with pediatric stroke. Three SNPs under investigation are associated with a protective effect in CA pathogenesis (ADAMTS12 variant rs1364044: OR 0.65, p = 0.0001; and ADAMTS13 variants rs739469 and rs4962153: OR 0.77 and 0.63, p = 0.02 and 0.0006, respectively), while 2 other ADAMTS13 variants may confer a significant risk (rs2301612: OR 1.26, p = 0.011; rs2285489: OR 1.24, p = 0.02). coNclusioNs These results suggest that reduced integrity of the endothelial wall, as conferred by ADAMTS variants, together with inflammatory processes and defective vascular remodeling plays an important role in CA pathogenesis, although the mechanism of action remains unknown. The authors' findings may lead to specific screening of at-risk populations in the future.

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“…It is suggested that formation of an intracranial aneurysm is a consequence of a systemic vascular pathology, which is associated with pleomorphism in different candidate genes (Toth et al, 2000; Krex et al, 2001; Yurt et al, 2010). A higher prevalence of aneurysms in the cerebrovascular system may also be due to alterations in hemodynamic and histological characteristics (Stehbens, 1990; Kondo et al, 1997; Rowe et al, 2003; Shojima et al, 2004).…”

Section: Cerebrovascular Anatomy and Pathophysiology Of Aneurysmsmentioning

confidence: 99%

Intracranial Aneurysms: Review of Current Treatment Options and Outcomes

Seibert¹,

Tummala²,

Chow³

et al. 2011

Front. Neur.

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Intracranial aneurysms are present in roughly 5% of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors such as age, hypertension, pre-existing familial conditions, and smoking. Subarachnoid hemorrhage, the most common presentation due to aneurysm rupture, represents a serious medical condition often leading to severe neurological deficit or death. Recent technological advances in imaging modalities, along with increased understanding of natural history and prevalence of aneurysms, have increased detection of asymptomatic unruptured intracranial aneurysms (UIA). Studies reporting on the risk of rupture and outcomes have provided much insight, but the debate remains of how and when unruptured aneurysms should be managed. Treatment methods include two major intervention options: clipping of the aneurysm and endovascular methods such as coiling, stent-assisted coiling, and flow diversion stents. The studies reviewed here support the generalized notion that endovascular treatment of UIA provides a safe and effective alternative to surgical treatment. The risks associated with endovascular repair are lower and incur shorter hospital stays for appropriately selected patients. The endovascular treatment option should be considered based on factors such as aneurysm size, location, patient medical history, and operator experience.

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Biomarkers of connective tissue disease in patients with intracranial aneurysms

Cited by 5 publications

References 28 publications

Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms

ADAMTS genes and the risk of cerebral aneurysm

Intracranial Aneurysms: Review of Current Treatment Options and Outcomes

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