2007
DOI: 10.1111/j.1582-4934.2007.00092.x
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Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre‐disposition pending between fiction and reality

Abstract: Fibrosis is a frequent, life-threatening complication of most chronic liver diseases. Despite major achievements in the understanding of its pathogenesis, the translation of this knowledge into clinical practice is still limited. In particular, non-invasive and reliable (serum-) biomarkers indicating the activity of fibrogenesis are scarce. Class I biomarkers are defined as serum components having a direct relation to the mechanism of fibrogenesis, either as secreted matrix-related components of activated hepa… Show more

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Cited by 85 publications
(75 citation statements)
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References 135 publications
(123 reference statements)
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“…The results of this study indicated that the concentration of the circulating HA in dogs with liver cirrhosis is higher than that of dogs with non-cirrhotic liver disease. This result is in part consistent with the reports obtained with respect to humans [6,7,10,11,13], and suggests that the concentration of HA in canine blood may be a clinically important diagnostic test for dogs and may function as markers of cirrhosis in those with hepatic disease. HA concentration of group 1 was significantly higher than dogs with extrahepatic disease (group 3), although neither did we observe that HA concentration of group 1 was higher than that of the control group (Fig.…”
supporting
confidence: 82%
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“…The results of this study indicated that the concentration of the circulating HA in dogs with liver cirrhosis is higher than that of dogs with non-cirrhotic liver disease. This result is in part consistent with the reports obtained with respect to humans [6,7,10,11,13], and suggests that the concentration of HA in canine blood may be a clinically important diagnostic test for dogs and may function as markers of cirrhosis in those with hepatic disease. HA concentration of group 1 was significantly higher than dogs with extrahepatic disease (group 3), although neither did we observe that HA concentration of group 1 was higher than that of the control group (Fig.…”
supporting
confidence: 82%
“…1) nor signified the correlation between the histological extent of hepatic fibrosis and blood HA level in group 1 (data not shown). In contrast, it has been reported that most of the human patients with hepatitis have higher HA concentration than the healthy controls and the degree of HA concentration is correlated to that of histological fibrosis [6,7,10,11,13]. In this study various types of hepatitis were included.…”
mentioning
confidence: 99%
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“…For F2 and F3 disease the correlation is less clear and individuals with readings between 7.65 and 13 kPa should be considered for biopsy when this will alter the treatment of their disease [33,34]. Alternatively, a myriad of noninvasive tests based on biochemical markers are available [33][34][35][36]. In individuals with F2/F3 disease on FibroScan, one of these serum biochemical marker tests may be utilized.…”
Section: Investigations For Liver Diseasementioning
confidence: 99%
“…If the test correlates with the degree of fibrosis suggested by FibroScan then liver biopsy may be avoided [33]. Biochemical markers should not be used as the sole test for fibrosis [33][34][35][36].…”
Section: Investigations For Liver Diseasementioning
confidence: 99%