Biomarkers of non-specific inflammation and atherosclerosis of carotid arteries in obstructive sleep apnea syndrome

Abstract

Purpose of study. Identification of significant laboratory markers for the development of atherosclerosis (AS) of the carotid arteries (CA) in patients with obstructive sleep apnea syndrome (OSAS).Materials and methods. 152 male patients were examined, 84 of whom, according to polysomnography (PSG), were diagnosed with OSAS. Diagnosis of AS CA was performed by triplex scanning. The complex of laboratory studies included the assessment of lipid metabolism, the concentration of highly sensitive C-reactive protein (hsCRP), interleukin‑1β (IL‑1β), interleukin‑6 (IL‑6) and interleukin‑10 (IL‑10) in blood serum.Results. In patients with OSAS, a statistically significant increase in the complex of proatherogenic factors was found: hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient compared with patients without OSAS despite the absence of differences in the severity of atherosclerotic lesions of the carotid arteries in these groupsConclusion. The development of OSAS is associated with severe lipid metabolism disorders and activation of nonspecific inflammation, which determines an increased risk of atherosclerosis in this group of patients.

24-hour blood pressure profile and systemic inflammation in patients with stable coronary artery disease with obstructive sleep apnea

“…В проведенных исследованиях у пациентов с ОАС наблюдалось повышение уровня провоспалительных цитокинов, включая интерлейкин-6, интерлейкин-1, С-реактивный белок и фактор некроза опухоли α, а также признаки активации лейкоцитов [24]. Появляется все больше доказательств того, что уровни нейтрофилов, лимфоцитов и моноцитов повышаются при ограничении сна и, что их соотношение независимо связано с тяжестью ОАС [25].…”