Biomaterial and biocompatibility evaluation of tunicate nanocellulose for tissue engineering

Apelgren, Peter; Sämfors, Sanna; Säljö, Karin; Mölne, Johan; Gatenholm, Paul; Troedsson, Christofer; Thompson, Eric M.; Kölby, Lars

doi:10.1016/j.bioadv.2022.212828

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…Tunicates are the only animals that produce cellulose. The aquaculture of tunicates for production of cellulose can be advantageous in the sense that carbon sequestration can be returned to the ocean floor. − The tunicate cellulose extracted from its outer capsule, tunic, is superior to plant cellulose with a highly reactive surface area, which makes it an excellent source as a composite material. Tunicates of class Ascidiacea also called sea squirts are the only variety that can produce cellulose, and they are the main focus of researchers for cellulose production .…”

Section: Sources Of Nanocellulosementioning

confidence: 99%

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Sreedharan,

Vijayamma,

Liyaskina

et al. 2024

Biomacromolecules

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Cellulose, the most abundant polymer on Earth, has been widely utilized in its nanoform due to its excellent properties, finding applications across various scientific fields. As the demand for nanocellulose continues to rise and its ease of use becomes apparent, there has been a significant increase in research publications centered on this biomaterial. Nanocellulose, in its different forms, has shown tremendous promise as a tissue engineered scaffold for regeneration and repair. Particularly, nanocellulose-based composites and scaffolds have emerged as highly demanding materials for both soft and hard tissue engineering. Medical practitioners have traditionally relied on collagen and its analogue, gelatin, for treating tissue damage. However, the limited mechanical strength of these biopolymers restricts their direct use in various applications. This issue can be overcome by making hybrids of these biopolymers with nanocellulose. This review presents a comprehensive analysis of the recent and most relevant publications focusing on hybrid composites of collagen and gelatin with a specific emphasis on their combination with nanocellulose. While bone and skin tissue engineering represents two areas where a majority of researchers are concentrating their efforts, this review highlights the use of nanocellulose-based hybrids in these contexts.

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Section: Sources Of Nanocellulosementioning

confidence: 99%

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Sreedharan,

Vijayamma,

Liyaskina

et al. 2024

Biomacromolecules

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“…24,122,123 Tunicate-derived cellulose nanofibrils (TNC)-based bioinks present excellent printability and biocompatibility for cartilage repair (119). 124 However, challenges remain in optimizing cellulose-based bioinks for specific tissue engineering applications. 125 Cellulose-based bioinks offer promise for tissue engineering due to their biocompatibility, 126 biodegradability, 127,128 and mechanical strength, but face challenges such as surface roughness and degradation rate.…”

Section: Nanomaterials-based Hybrid Bioinksmentioning

confidence: 99%

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Chandra,

Reis,

Kundu

et al. 2024

ACS Biomater. Sci. Eng.

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3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

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“…The tunicate is an emerging source of cellulose that can be grown underwater and does not compete with land farming. CNF from tunicate have shown promising results for tissue engineering [ 128 ]. High purity Iβ cellulose can be extracted from tunicate.…”

Section: Biopolymers For Additive Manufacturingmentioning

confidence: 99%

Polysaccharides and Structural Proteins as Components in Three-Dimensional Scaffolds for Breast Cancer Tissue Models: A Review

Pasquier¹,

Rosendahl

Solberg³

et al. 2023

Bioengineering

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Breast cancer is the most common cancer among women, and even though treatments are available, efficiency varies with the patients. In vitro 2D models are commonly used to develop new treatments. However, 2D models overestimate drug efficiency, which increases the failure rate in later phase III clinical trials. New model systems that allow extensive and efficient drug screening are thus required. Three-dimensional printed hydrogels containing active components for cancer cell growth are interesting candidates for the preparation of next generation cancer cell models. Macromolecules, obtained from marine- and land-based resources, can form biopolymers (polysaccharides such as alginate, chitosan, hyaluronic acid, and cellulose) and bioactive components (structural proteins such as collagen, gelatin, and silk fibroin) in hydrogels with adequate physical properties in terms of porosity, rheology, and mechanical strength. Hence, in this study attention is given to biofabrication methods and to the modification with biological macromolecules to become bioactive and, thus, optimize 3D printed structures that better mimic the cancer cell microenvironment. Ink formulations combining polysaccharides for tuning the mechanical properties and bioactive polymers for controlling cell adhesion is key to optimizing the growth of the cancer cells.

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Biomaterial and biocompatibility evaluation of tunicate nanocellulose for tissue engineering

Cited by 11 publications

References 53 publications

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Polysaccharides and Structural Proteins as Components in Three-Dimensional Scaffolds for Breast Cancer Tissue Models: A Review

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