Biomaterial‐Based Approaches to Address Vein Graft and Hemodialysis Access Failures

Boire, Timothy C.; Balikov, Daniel A.; Lee, Yunki; Guth, Christy M.; Cheung‐Flynn, Joyce; Sung, Hak Joon

doi:10.1002/marc.201600412

Cited by 9 publications

(11 citation statements)

References 211 publications

(271 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since surrounding the vein with a microporous ceramic (with or without contact) induced luminal sprouting: we speculated that, as reported previously, the effect should be material‐independent since all manner of porous external stent materials with pose sizes in the range (50–750 µm) resulted in formation of a neovasa vasorum in arterialized vein grafts . We posited that if microporosity were driving the lumen of the blood vessels to branch, then comparable polymer microstructures would also induce sprouting.…”

Section: Resultsmentioning

confidence: 60%

See 1 more Smart Citation

Biomaterial‐Induction of a Transplantable Angiosome

Charbonnier

Maillard

Sayed

et al. 2019

Adv Funct Materials

View full text Add to dashboard Cite

Creating transplantable vascular networks (angiosomes) that are fed and drained by vessels large enough to be surgically reconnected is key to harnessing the potential of regenerative medicine and advancing reconstructive surgical techniques. Currently, the only way to create a new angiosome is nontrivial and involves pressurizing a vein graft by its surgical attachment to an artery forming an arteriovenous loop (AVL). Material induction of a venous angiosome is reported, by placement of a 3D printed microporous monetite scaffold around a vein and its transplantability is further demonstrated. When the transplanted venosome is cut, it bleeds, illustrating potential reconstructive functionality. The volume of blood vessels generated by biomaterial-induction is as great as by AVL. Direct contact of the material with the vein does not appear to be critical to luminal sprouting, and wrapping the implant in a silicone membrane significantly reduces sprouting. Pilot studies with microporous polymeric scaffolds induce far less vascular invasion. After 4 weeks, monetite scaffolds are extensively vascularized and can be transplanted to an arterial vessel. This report is significant since a lack of tools to control vascular generation is an impediment to the treatment of several conditions that give rise to tissue ischemia and tissue reconstruction.

show abstract

Section: Resultsmentioning

confidence: 60%

“…However some literature examines the effect of materials placed around blood vessels as external stents. Polymeric meshes have been demonstrated to reduce narrowing of vein grafts, (that are used as coronary bypasses for example) and porosity was found to be critical for the effect, but no mechanism was proposed …”

Section: Introductionmentioning

confidence: 99%

Biomaterial‐Induction of a Transplantable Angiosome

Charbonnier

Maillard

Sayed

et al. 2019

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Moreover, the external scaffolds made of other collagen or polymer have been widely used in the study of inhibiting the neointimal proliferation and maintaining the fluidity of vein grafts, and have shown remarkable effect and gratifying application prospect. 105 What's more interesting is that nanomaterials can also be used to treat and prevent AF. A nanostructured film fabricated with Parylene-C was loaded with dexamethasone and amiodarone, and then was localized to epicardium of rabbit model to inhibit perioperative inflammation and AF.…”

Section: Nanomaterials For Cvdsmentioning

confidence: 99%

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

Li¹,

Liang²,

Xiao³

et al. 2018

IJN

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium. In addition, they may bring some unpleasant side effects. Therefore, it is vital to find and explore new technologies and drugs to solve the shortcomings of conventional treatments. Nanotechnology is a new way of using and manipulating the matter at the molecular scale, whose functional organization is measured in nanometers. Because nanoscale phenomena play an important role in cell signal transduction, enzyme action and cell cycle, nanotechnology is closely related to medical research. The application of nanotechnology in the field of medicine provides an alternative and novel direction for the treatment of CVDs, and shows excellent performance in the field of targeted drug therapy and the development of biomaterials. This review will briefly introduce the latest applications of nanotechnology in the diagnosis and treatment of common CVDs.

show abstract

“…Systemic therapeutics to improve maturation and patency have so far exhibited little to marginal benefit (Alexander et al, 2005; Boire et al, 2016; Chesebro et al, 1984; Conte et al, 2006; Dixon et al, 2009; Goldman et al, 1994; Muto, Model, Ziegler, Eghbalieh, & Dardik, 2010), motivating us to prioritize therapeutic (Evans, Hocking, Kilchrist, et al, 2015; Evans, Hocking, Osgood et al, 2015) and/or device approaches localized to the vein graft, especially near the venous anastomosis where stenotic lesions typically develop (Badero, Salifu, Wasse, & Work, 2008; Cunnane, Cunnane, & Walsh, 2017; MacRae et al, 2016; Roy‐Chaudhury, Sukhatme, & Cheung, 2006; Sivanesan, How, & Bakran, 1999). Perivascular approaches have focused primarily on either promoting processes involved in outward remodeling (e.g., adventitial angiogenesis or elastin fragmentation) (Hye et al, 2014) or attenuating vein wall tension and stresses with mechanical support.…”

Section: Introductionmentioning

confidence: 99%

Effect of pore size and spacing on neovascularization of a biodegradble shape memory polymer perivascular wrap

Boire

Himmel

et al. 2020

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Neointimal hyperplasia (NH) is a main source of failures in arteriovenous fistulas and vascular grafts. Several studies have demonstrated the promise of perivascular wraps to reduce NH via promotion of adventitial neovascularization and providing mechanical support. Limited clinical success thus far may be due to inappropriate material selection (e.g., nondegradable, too stiff) and geometric design (e.g., pore size and spacing, diameter). The influence of pore size and spacing on implant neovascularization is investigated here for a new biodegradable, thermoresponsive shape memory polymer (SMP) perivascular wrap. Following an initial pilot, 21 mice were each implanted with six scaffolds: four candidate SMP macroporous designs (a–d), a nonporous SMP control (e), and microporous GORETEX (f). Mice were sacrificed after 4 (N = 5), 14 (N = 8), and 28 (N = 8) days. There was a statistically significant increase in neovascularization score between all macroporous groups compared to nonporous SMP (p < .023) and microporous GORETEX (p < .007) controls at Day 28. Wider‐spaced, smaller‐sized pore designs (223 μm‐spaced, 640 μm‐diameter Design c) induced the most robust angiogenic response, with greater microvessel number (p < .0114) and area (p < .0055) than nonporous SMPs and GORETEX at Day 28. This design also produced significantly greater microvessel density than nonporous SMPs (p = 0.0028) and a smaller‐spaced, larger‐sized pore (155 μm‐spaced, 1,180 μm‐sized Design b) design (p = .0013). Strong neovascularization is expected to reduce NH, motivating further investigation of this SMP wrap with controlled pore spacing and size in more advanced arteriovenous models.

show abstract

Biomaterial‐Based Approaches to Address Vein Graft and Hemodialysis Access Failures

Cited by 9 publications

References 211 publications

Biomaterial‐Induction of a Transplantable Angiosome

Biomaterial‐Induction of a Transplantable Angiosome

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

Effect of pore size and spacing on neovascularization of a biodegradble shape memory polymer perivascular wrap

Contact Info

Product

Resources

About